A TALE OF CAPTOPRIL DETECTION BASED ON AN ELECTROCHEMICAL MIP SENSOR

Yıl 2024, , 568 - 575, 20.05.2024

Aysu Yarman , Sevinç Kurbanoğlu

https://doi.org/10.33483/jfpau.1420660

Öz

Objective: In this study, it was aimed to develop a voltammetric method using sensors prepared with the molecular imprinting technique for the detection of Captopril, an antihypertensive drug.
Material and Method: With the molecular imprinting method, molecularly imprinted polymers were formed on the surfaces of glassy carbon electrodes. The analysis of Captopril was carried out using the differential pulse voltammetry method, and the performance of the sensor was examined.
Result and Discussion: A linear analysis was performed up to 50 pM Captopril with a limit of detection value of 2.62 pM. Selectivity studies have shown that Captopril has a higher electrochemical response than other interfering substances, such as paracetamol, ascorbic acid, and L-proline.

Anahtar Kelimeler

Biomimetic sensors, buffer effect, captopril, molecularly imprinted polymers

Etik Beyan

The authors declare that this study does not require the ethics committee's approval.

Teşekkür

As women in science, we express our gratitude to our great leader M. Kemal ATATÜRK, on the 100th anniversary of the Republic of Türkiye.

KAPTOPRİL TESPİTİ İÇİN ELEKTROKİMYASAL BİR MIP SENSÖRÜNÜN HİKAYESİ

Öz

Amaç: Bu çalışmada antihipertansif bir ilaç olan Kaptoprilin tespitine yönelik moleküler baskılama yöntemi ile hazırlanmış sensörler kullanılarak voltametrik bir yöntem geliştirilmesi amaçlanmıştır.
Gereç ve Yöntem: Moleküler baskılama yöntemi ile camsı karbon elektroların yüzeylerinde moleküler baskınlanmış polimerler oluşturulmuş ve differansiyel puls voltammetri yöntemi ile Kaptoprilin analizi gerçekleştirilmiş, sensörün performansı incelenmiştir.
Sonuç ve Tartışma: 2,62 pM teşhis sınırı değeri ile 50 pM Kaptopril seviyesine kadar doğrusal bir analiz gerçekleştirilmiştir. Seçicilik çalışmaları, Kaptoprilin, diğer girişim yapabilecek, parasetamol, askorbik asit ve L-prolin gibi maddelere göre daha yüksek elektrokimyasal cevaba sahip olduğunu göstermiştir.

Anahtar Kelimeler

Biyomimetik sensörler, kaptopril, moleküler baskılanmış polimerler, tampon çözelti etkisi

Kaynakça

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