EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS

Yıl 2024, , 535 - 543, 20.05.2024

Burcu Sezgin , Murat Soyseven

https://doi.org/10.33483/jfpau.1425350

Öz

Objective: In our study, it was aimed to make a comparative analysis of the environmental impact profiles of two approaches including Gas Chromatography (GC) and Liquid Chromatography (LC) methods, which are frequently used techniques for the determination of non-steroidal anti-inflammatory drugs (NSAIDs) and their metabolites in environmental water samples.
Material and Method: The evaluation of the methods' environmental impact was performed using National Environmental Methods Index Label (NEMI), Analytical Eco-scale, Analytical GREEnness Metric (AGREE), and Green Analytical Procedure Index (GAPI).
Result and Discussion: The routine analysis of NSAIDs in environmental waters is carried out, resulting in a significant volume of chemical waste. In recent times, there has been a growing significance attributed to environmentally conscious analytical methodologies and the evaluation of methodologies through a green lens to confront this challenge. There is no statistically significant difference in terms of environmental impact profile was observed between the two methods compared.

Anahtar Kelimeler

Environmental waters, green chemistry, greenness assessment, nonsteroidal anti-inflammatory drugs (NSAIDs)

SIK KULLANILAN NONSTEROİD ANTİ-İNFLAMATUVAR İLAÇLARIN (NSAİİ) ÇEVRESEL SULARDA TAYİNİ İÇİN GELİŞTİRİLMİŞ ÇEŞİTLİ YÖNTEMLERİN YEŞİLLİK PROFİLLERİNİN DEĞERLENDİRİLMESİ

Öz

Amaç: Çalışmamızda, çevresel su örneklerinde steroid olmayan antiinflamatuar ilaçların (NSAİİ) ve bunların metabolitlerinin tayininde sıklıkla kullanılan teknikler olan Gaz Kromatografisi (GK) ve Sıvı Kromatografisi (SK) yöntemlerini içeren iki yaklaşımın çevresel etki profillerinin karşılaştırmalı bir analizinin yapılması amaçlanmıştır.
Gereç ve Yöntem: Yöntemlerin çevresel etkisinin değerlendirilmesi, Ulusal Çevresel Yöntemler İndeks Etiketi (NEMI), Analitik Eko-ölçek, Analitik Yeşillik Metriği (AGREE) ve Yeşil Analitik Prosedür İndeksi (GAPI) kullanılarak gerçekleştirilmiştir.
Sonuç ve Tartışma: Çevresel sularda NSAİİ'lerin rutin analizi gerçekleştirilmekte ve bunun sonucunda önemli miktarda kimyasal atık ortaya çıkmaktadır. Son zamanlarda, çevreye duyarlı analitik metodolojilere ve bu zorluğun üstesinden gelmek için metodolojilerin yeşil bir mercekle değerlendirilmesine atfedilen önem giderek artmaktadır. Karşılaştırılan iki yöntem arasında çevresel etki profili açısından istatistiksel olarak anlamlı bir fark olmadığı gözlenmiştir.

Anahtar Kelimeler

Çevresel sular, nonsteroid anti-inflamatuvar ilaçlar (NSAİİ), yeşil kimya, yeşillik değerlendirmesi

Kaynakça

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