PROPOLİS YÜKLÜ BUKKAL YAMALARIN TASARIMI VE DEĞERLENDİRİLMESİ

Öz

Amaç: Etkili bir tedaviye ulaşmak için uygun bir uygulama aracı gerektiren bir durum olan aftöz stomatitte propolis kesinlikle önerilir. Bu endikasyon için uzun süreli mukozal temas ve koruma sağlayan bukkal yama faydalı olur. Buna göre bu çalışmada, tamamlayıcı özelliklere sahip üç polimerden (aljinat, karboksimetilselüloz ve polivinilpirolidon) oluşan propolis yüklü bukkal yamaları ve bunların optimum özelliklere sahip yamayı üretmek için uygun kombinasyonu tasarlanmıştır. Gereç ve Yöntem: Döküm yöntemiyle farklı polimer oranlarına sahip dokuz yama hazırlanmış, şişme, yapışma süresi ve gücü ile çözünme hızı açısından değerlendirilmiştir. Sonra yamaların özellikleri yapay sinir ağı analizi kullanılarak ilişkilendirilmiştir. Sonuç ve Tartışma: Sonuçlar, tüm yamaların pürüzsüz, yarı şeffaf ve esnek ile yüzey pH'ının 6,5 ile 7,4 arasında olduğunu göstermiştir. Polimer bileşimiyle ölçülen özellikler arasındaki korelasyon karmaşık ve doğrusal değildir. Bu nedenle bu özellikleri analiz ve optimize etmek için yapay sinir ağı kullanılmıştır. Bu analizin modeli, uygun çekme ve yapışma gücü için daha yüksek ağırlıklar sağlarken şişme, sertlik ve hızlı çözünme oranını olumsuz olarak değerlendirir. Toplama analizine göre, sırasıyla 15,5 ve 13'lük CMC% ve PVP% kombinasyonu, en iyi 3,5 puan sağlar.

Anahtar Kelimeler

• Aljinat yamalar
• bukkal yamalar
• mukoadezif polimerleri
• propolis

DESIGN AND EVALUATION OF PROPOLIS-LOADED BUCCAL PATCHES

Öz

Objective: Propolis is highly recommended in aphthous stomatitis, a condition that requires a proper delivery tool to achieve an efficient treatment. For this indication, a buccal patch that provides prolonged mucosal contact and protection would be beneficial. Accordingly, in this study, we designed propolis-loaded buccal patches, composed of three polymers (alginate, carboxymethylcellulose, and polyvinylpyrrolidone) of complementary properties, and the proper combination of them to produce the patch of optimum properties. Material and Method: Nine patches of different polymer ratios were prepared by casting method and evaluated by assessing their swelling, adhesion time and strength, and dissolution rate. Then the patches properties were correlated using artificial neural network analysis. Result and Discussion: The results showed that all patches were smooth, translucent, and flexible with surface pH between 6.5 and 7.4. The correlation between polymer composition and measured properties was complex and non-linear. Therefore, an artificial neural network was used to analyze these properties and optimize them. The model of this analysis provides higher weights for favorable tensile and adhesion strengths while considering swelling, rigidity, and fast dissolution rate as unfavorable. According to summation analysis, the combination of CMC% and PVP% of 15.5 and 13, respectively, provides the best score of 3.5.

Anahtar Kelimeler

• Alginate patches
• buccal patches
• mucoadhesive polymers
• propolis

Destekleyen Kurum

none to declare

Etik Beyan

none to declare

Teşekkür

The authors express their thanks to the college of pharmacy/ University of Mosul.

Kaynakça

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