TAHMİNİ GLOMERÜLER FİLTRASYON HIZININ FARKLI FORMÜLLERLE TÜRK POPÜLASYONUNDA KIYASLANMASI

Öz

Amaç: Glomerüler filtrasyon hızlarını (GFR) tahmin etmek için klinik uygulamada genellikle kreatinin bazlı formüller kullanılır, ancak değerler genellikle tutarlı değildir. Bu çalışmanın amacı farklı formüller kullanarak eGFR değerleri arasındaki farkı değerlendirmektir. Gereç ve Yöntem: Ocak-Aralık 2021 tarihleri arasında serum kreatinin ölçümü yapılan ve demografik verileri eksiksiz olan yetişkin Türk hastalar çalışmaya dahil edildi. GFR değerleri 5 farklı formül kullanılarak hesaplandı. Cockcroft-Gault ile hesaplanan GFR, vücut yüzey alanına göre normalize edilerek karşılaştırmaya eklendi. GFR değerleri ile KDIGO evreleri arasındaki fark değerlendirildi. Hastaların albumin/kreatinin oranı (ACR) da değerlendirmeye alındı. Sonuç ve Tartışma: Ortalama yaşı 52.92 yıl olan toplam 305 hasta çalışmaya dahil olmuştur. Ortanca değerleri 51.70 ila 71.77 ml/dak/1.73m2 arasında değişen altı farklı GFR hesaplaması kaydedilmiştir. Türk popülasyonu için ırk kastsayısı içeren The Modification of Diet in Renal Disease formülü en düşük eGFR değerleri ile sonuçlanmıştır. Sadece 42 hastanın ACR verisi bulunmuştur ve bu değerleri tüm GFR değerleri ile negatif, tüm KDIGO evreleri ile pozitif korelasyon göstermiştir (p<0.05). Hasta demografisine ve/veya denklemlere bağlı olarak GFR değerlerinde kayda değer farklılıklar görülmüştür. Genel ve spesifik hasta popülasyonlarında GFR'yi tahmin etmek için yeni pratik yöntemlere ihtiyaç vardır.

Anahtar Kelimeler

• Böbrek fonksiyonu
• eGFR varyasyonları
• GFR hesaplaması
• glomerüler filtrasyon hızı
• kreatinin klerensi

COMPARISON OF ESTIMATED GLOMERULAR FILTRATION RATE USING DIFFERENT FORMULAS IN TURKISH POPULATION

Öz

Objective: Creatinine-based equations are generally used in clinical practice to estimate glomerular filtration rates (GFR), but values are not usually consistent. This study aimed to evaluate the difference between estimated GFR values using different equations. Material and Method: Adult Turkish patients with serum creatinine measurements between January to December 2021 and complete demographic data were included. GFR values were calculated using 5 different formulas. GFR calculated with Cockcroft-Gault were normalized to body surface area and added to the comparison. Difference between GFR values and KDIGO stages were evaluated. Albunin/creatinine ratio (ACR) of patients was also assessed. Result and Discussion: A total of 305 patients with average age of 52.92 years were included. Six different GFR calculations were recorded with median values between 51.70 to 71.77 ml/min/1.73m2. Formula of The Modification of Diet in Renal Disease with the race factor for Turkish population resulted in the lowest eGFR values. The ACR values of only 42 patients were available and it was negatively correlated to all GFR values and positively correlated to all KDIGO stages (p<0.05). There were noteworthy variations in GFR values, based on patient demographics and/or equations. The need for novel practical methods for estimating GFR in general and specific patient populations are necessary.

Anahtar Kelimeler

• Creatinine clearance
• eGFR variations
• GFR calculation
• glomerular filtration rate
• kidney function

Etik Beyan

The institutional ethics committee review board approved this study (No:2022-389) and waived consent.

Kaynakça

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