DİYABETTE KAN GLUKOZ SEVİYESİNİN DÜZENLENMESİ İÇİN GLUKOZ METABOLİZMASINDA BİTKİ METABOLİTLERİNİN ETKİSİ: ÖZEL GÜNCELLEME

Öz

Amaç: Bu makalenin amacı, bitki kimyasallarının moleküler hedeflerini ve hiperglisemiyi düzenlemedeki rollerini araştırmak, bu durum için yeni tedaviler geliştirmeye yönelik potansiyel stratejiler hakkında fikir vermektir. Sonuç ve Tartışma: Şeker regülasyonunda yer alan biyokimyasal yolların anlaşılması, hiperglisemi gibi durumlara yönelik tedavilerin geliştirilmesi açısından çok önemlidir. Bitkilerden elde edilen fitokimyasallar, çeşitli moleküler hedefler aracılığıyla kan şekeri seviyelerinin düzenlenmesinde umut vaat etmektedir. Glikoz metabolizmasında yer alan spesifik enzimleri ve yolakları hedef alan bu fitokimyasallar, hipergliseminin yönetilmesinde potansiyel terapötik faydalar sunar. Bitki kimyasalları, glikoz metabolizmasında yer alan anahtar enzimleri ve yolakları etkileme yeteneğini göstermiştir. Fitokimyasalların glikolizi, Krebs döngüsünü ve glukoneogenezi modüle ettiği ve kan şekeri seviyelerini düzenleme potansiyeli sunduğu bulunmuştur. Ek olarak, bu bitki özlerinin kolesterol sentezi, glikojen sentezi ve bozulması, karbonhidrat metabolizması ve emiliminin yanı sıra insülin üretimi ve salınımı gibi süreçler üzerinde de etkileri olduğu gösterilmiştir. Bu şifalı bitkilerin çoklu fizyolojik süreçler üzerindeki farklı etkisi, bunların hiperglisemiyi çok yönlü bir yaklaşımla ele alma potansiyelini vurgulamaktadır. Bu derlemede, bu bitki kimyasallarının moleküler hedeflerinin ve etki mekanizmalarının daha fazla araştırılması, hiperglisemiye yönelik yeni tedavilerin geliştirilmesi için değerli bilgiler sağlayabilir.

Anahtar Kelimeler

• Biyokimyasal yolaklar
• diyabet
• fitokimyasallar
• tıbbi bitkiler

IMPACT OF PLANT METABOLITES IN GLUCOSE METABOLISM FOR REGULATION OF BLOOD GLUCOSE LEVEL IN DIABETES: AN EXCLUSIVE UPDATE

Öz

Objective: To explore the molecular targets of plant chemicals and their role in regulating hyperglycemia, providing insights into potential strategies for developing new treatment for this condition. Result and Discussion: Understanding the biochemical pathways involved in sugar regulation is crucial for developing treatments for conditions such as hyperglycemia. Phytochemicals derived from plants have shown promise in regulating blood sugar levels through various molecular targets. By targeting specific enzymes and pathways involved in glucose metabolism, these phytochemicals offer potential therapeutic benefits for managing hyperglycemia. Plant chemicals have demonstrated the ability to influence key enzymes and pathways in glucose metabolism. Phytochemicals have been found to modulate glycolysis, the Krebs cycle, and gluconeogenesis, offering the potential for regulating blood sugar levels. Additionally, these plant extracts have shown effects on processes such as cholesterol synthesis, glycogen synthesis and degradation, carbohydrate metabolism and absorption, as well as insulin production and release. The diverse impact of these medicinal plants on multiple physiological processes highlights their potential to address hyperglycemia through a multi-faceted approach. In this review, we will further explore the molecular targets and mechanisms of action of these plant chemicals, which can provide valuable insights for developing novel treatments for hyperglycemia.

Anahtar Kelimeler

• Biochemical pathways
• diabetes
• medicinal plants
• phytochemicals

Kaynakça

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