THE PATHOGENIC LINK BETWEEN INSULIN RESISTANCE AND ALZHEIMER'S DISEASE: THE PHARMACOLOGICAL INTERVENTIONS

Öz

Objective: Alzheimer's disease is one of the most challenging and devastating neurodegenerative diseases affecting millions worldwide. Alzheimer's disease enforces a significant public health burden, profoundly impacting patients and their families. Several genetic and environmental factors influence Alzheimer's disease pathophysiology. Alzheimer's disease is highly associated with insulin resistance disorders like metabolic syndrome, obesity, and type 2 diabetes mellitus. This frequently reveals a common underlying pathophysiological link between insulin resistance disorders and Alzheimer's disease, potentially stemming from both genetic and non-genetic factors. Result and Discussion: To date, Alzheimer's disease pharmacological treatments focus on managing symptoms rather than halting pathophysiological factors. However, there is growing interest in targeting the shared pathogenic pathways between Alzheimer's disease and insulin resistance disorders with pharmacological interventions as a promising approach to treating Alzheimer's disease. This review examines the literature on the pathophysiological link between Alzheimer's disease and insulin resistance and the pharmacological treatments aimed at targeting this link.

Anahtar Kelimeler

• Alzheimer
• diabetes
• insulin resistance
• neurodegenerative
• therapeutics

İNSÜLİN DİRENCİ VE ALZHEİMER HASTALIĞI ARASINDAKİ PATOJENİK BAĞLANTI: FARMAKOLOJİK MÜDAHALELER

Öz

Amaç: Alzheimer hastalığı, dünya çapında milyonlarca insanı etkileyen, en zorlu ve yıkıcı nörodejeneratif hastalıklardan biridir. Bu hastalık, hastaları ve ailelerini derinden etkileyen önemli bir halk sağlığı yükü oluşturmaktadır. Alzheimer hastalığının patofizyolojisini çeşitli genetik ve çevresel faktörler etkilemektedir. Ayrıca, Alzheimer hastalığı, metabolik sendrom, obezite ve tip 2 diyabet gibi insülin direnci bozukluklarıyla yüksek oranda ilişkilidir. Bu durum, Alzheimer hastalığı ile insülin direnci bozuklukları arasında, hem genetik hem de genetik olmayan faktörlerden kaynaklanabilecek potansiyel bir patofizyolojik bağlantının varlığını işaret etmektedir. Sonuç ve Tartışma: Bugüne kadar, Alzheimer hastalığının farmakolojik tedavileri, hastalığın patofizyolojik faktörlerini durdurmaktan ziyade semptomları yönetmeye odaklanmıştır. Bununla birlikte, Alzheimer hastalığının tedavisinde umut verici bir yaklaşım olarak, hastalık ile insülin direnci bozuklukları arasındaki ortak patojenik yolakların farmakolojik müdahalelerle hedeflenmesine yönelik ilgi giderek artmaktadır. Bu derleme, Alzheimer hastalığı ile insülin direnci arasındaki patofizyolojik bağlantı ve bu bağlantıyı hedef alan farmakolojik tedaviler hakkındaki literatürü incelemektedir.

Anahtar Kelimeler

• Alzheimer hastalığı
• diyabet
• insülin direnci
• nörodejenerasyon
• tedavi

Kaynakça

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