MELATONİNİN TİROİD FİZYOLOJİ VE HASTALIKLARI ÜZERİNDEKİ ROLÜNÜN DEĞERLENDİRİLMESİ

Öz

Amaç: Melatonin (MLT) büyük ölçüde triptofandan pinealositler içinde üretilir. Karanlıkta serotonin-N-asetiltransferaz aktivitesinde büyük bir artış olduğunda gerçekleşir ve serotoninin N-asetilserotonine dönüşmesine neden olur. MLT'nin bağlanma bölgeleri beynin birçok yerinde ve aynı zamanda bağışıklık sistemi, gonadlar, böbrek ve kardiyovasküler sistem hücrelerinde tespit edilmiştir. MLT, MT1 ve MT2 membran reseptörleri aracılığıyla birçok farmakolojik ve fizyolojik aktiviteyi etkiler. Ayrıca, reseptör aracılı olmayan etkileri ile antioksidan aktivite gösterir. MLT doğrudan veya dolaylı olarak tiroid bezini ve faaliyetlerini etkileyebilir. Altta yatan mekanizmaların dikkatle yorumlanması gerekmektedir. Sonuç ve Tartışma: Bu derlemede, MLT'nin tiroid bezi ve hormon salgısı üzerindeki tipik inhibitör etkilerinin yanı sıra antioksidan etkileri ve tiroid hastalıkları ile ilişkisi incelenmiştir.

Anahtar Kelimeler

• Hipotiroidizm
• melatonin
• melatonin reseptörleri
• tiroid kanseri
• tiroid fizyolojisi

Proje Numarası

19L0237007 NUMARALI ANKARA ÜNİVERSİTESİ BAP PROJESİ

EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES

Öz

Objective: Melatonin (MLT) is largely produced within the pinealocytes from tryptophan, happening during the dark. MLT’s binding sites have been established in numerous parts of the brain but also in the cells of the immune system, gonads, kidney, and cardiovascular system. MLT may directly or indirectly affect the thyroid gland and its activities. It can also prevent thyroid cell proliferation and interfere with thyroid hormone synthesis. The underlying mechanisms need to be carefully interpreted. Result and Discussion: In this review the typical inhibitory effects of MLT on the thyroid gland and hormone secretion, as well as its antioxidant effects and relationship with thyroid diseases is investigated.

Anahtar Kelimeler

• Hypothyroidism
• melatonin
• melatonin receptors
• thyroid cancer
• thyroid physiology

Destekleyen Kurum

ANKARA ÜNİVERSİTESİ BİLİMSEL ARAŞTIRMA PROJELERİ

Proje Numarası

19L0237007 NUMARALI ANKARA ÜNİVERSİTESİ BAP PROJESİ

Etik Beyan

Bu çalışmanın, özgün bir çalışma olduğunu; çalışmanın hazırlık, veri toplama, analiz ve bilgilerin sunumu olmak üzere tüm aşamalarından bilimsel etik ilke ve kurallarına uygun davrandığımı; bu çalışma kapsamında elde edilmeyen tüm veri ve bilgiler için kaynak gösterdiğimi ve bu kaynaklara kaynakçada yer verdiğimi; kullanılan verilerde herhangi bir değişiklik yapmadığımı, etik görev ve sorumluluklara riayet ettiğimi beyan ederim.

Teşekkür

Doktora çalışmalarına başlamak istediğimde, tüm sevgisi ile kucaklayan, bilgi birikimi ve tecrübeleri ile ışık tutan, her adımımda desteğini eksik etmeyen, uzun yıllar süren çalışmalarıma gösterdiği sabırdan dolayı danışman hocam Sayın Prof. Dr. Sibel Süzen’e, çalışmalarımızın temelini oluşturmamızda bize desteğini esirgemeyen tüm çalışmalarımın aydınlatılmasında A.Ü Eczacılık Fakültesi Merkez Laboratuvarı cihaz ve ekipmanları ile gece gündüz çalışan Sayın Prof. Dr. Hakan Göker’e, mikrobiyolojik çalışmalarımı gerçekleştiren Sayın Prof. Dr. Nurten Altanlar’a, deneylerimi tamamladığım Farmasötik Kimya Anabilim Dalı’nın değerli Öğretim Üyelerine, Araştırma Görevlileri ve Yüksek Lisans/ Doktora öğrencilerine, tüm çalışmalarımda bana kendiyle geçecek anne saatinden özveri de ve fedakarlıkta bulunup başarıma başarı katan ve yardım eden Sevgili Kızım İrem Ceylan’a, sabırla akademik çalışmalarıma destek veren Sevgili Eşim Selim Ceylan’a, doğduğum günden beri sevgilerini her konuda hissettiren verdiğim her kararda motive edici desteklerini esirgemeyen biricik annem ve babama, bu süreçte hayatıma dokunan tüm dostlarıma sonsuz sevgi ve saygılarımla teşekkür ederim.

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