PİROKSİKAM DİLALTI POLİMERİK FİLMLERİNİN HAZIRLANMASI VE İN VİVO DEĞERLENDİRİLMESİ

Öz

Amaç: Farklı ilaç uygulamalarının etken maddelerin etkinliğini arttırabildiği bilinmesine rağmen hangi ilaç salım sisteminin daha iyi olduğu konusunda birçok çalışma bulunmaktadır. Bunun nedeninin etken maddenin özelliklerine göre bu uygulamaların daha büyük avantaj sağlamasıdır. Bu çalışmada piroksikam dilaltı polimerik film uygulamasının potansiyel kullanımı araştırılmıştır. Gereç ve Yöntem: Çalışmada piroksikam dilaltı maltodekstrin ve pullulan içeren filmler hazırlanmış ve sağlıklı tavşan in vivo modelinde ilacın plazma düzeyleri araştırılmıştır. Sonuç ve Tartışma: İn vivo sonuçlar, tek doz uygulamadan sonra 10 saat içinde piroksikamın en yüksek plazma konsantrasyonlarına ulaştığını göstermiştir. Ayrıca plazma ilaç profilinde olası gastrointestinal emilime karşılık gelen ikinci bir tepe noktası oluşmamıştır. Özetle, piroksikam yüklü dilaltı polimerik film uygulamasının analjezik etkinin sağlanması amacıyla kullanılabilir özellikte olduğu tespit edilmiştir.

Anahtar Kelimeler

• Farmakokinetik
• film
• maltodekstrin
• piroksikam
• pullulan

PREPARATION AND IN VIVO EVALUATION OF PIROXICAM SUBGLINGUAL POLYMERIC FILMS

Öz

Objective: Although it is known that different drug applications can increase the effect of drugs, there are many studies that shows the superiority of different dosage forms. The reason of these different results is due to the different properties of used active ingredients. In this study, the potential use of piroxicam sublingual polymeric film application was investigated. Material and Method: In the study, maltodextrin and pullulan sublingual films containing piroxicam were prepared, and plasma levels of the drug were investigated in a healthy rabbit in vivo model. Result and Discussion: In vivo results showed that piroxicam reached its highest plasma concentrations within 10 hours after a single dose administration. Additionally, a second peak corresponding to possible gastrointestinal absorption did not occur in the plasma drug profile. In summary, it has been determined that piroxicam-loaded sublingual polymeric film application can be used to provide an analgesic effect.

Anahtar Kelimeler

• Film
• maltodextrin
• pharmacokinetic
• piroxicam
• pullulan

Kaynakça

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