THE ROLE OF NATURAL PRODUCTS IN THE TREATMENT OF DIABETIC NEUROPATHY

Öz

Objective: In parallel with the increase in diabetes mellitus in the world, diabetes-related secondary complications have become a global health problem. Among these, one of the most significant is diabetic neuropathy. When mechanism-based and symptomatic conventional treatments of diabetic neuropathy are examined, it is known that patients suffering from this condition do not yet have adequate treatment. In the current situation, it is seen that the search for new drugs is important. In this study, it was aimed to review the role of natural resources in the treatment of diabetic neuropathy on the basis of extracts and secondary compounds. Result and Discussion: Natural products are important for the development of new agents in the treatment of diabetes and its complications. In a comprehensive literature review, it has been observed that phenolic bioactive metabolites, especially flavonoids, provide effective results. Literature data reveals the importance of the relationship between phenolic metabolites and antioxidant mechanisms. Species containing phenolic-rich secondary metabolites identified as a result of preclinical and clinical studies for the treatment of diabetic neuropathy are widely distributed in Türkiye. It is thought that the taxa in the Flora of Türkiye will constitute a good resource for pharmaceutical research and development studies in this field.

Anahtar Kelimeler

• Diabetic neuropathy
• flavonoids
• hesperidin
• natural products
• quercetin

DOĞAL KAYNAKLARIN DİYABETİK NÖROPATİ TEDAVİSİNDEKİ ROLÜ

Öz

Amaç: Dünyada diabetes mellitus hastalığının artışına paralel olarak diyabet kaynaklı ikincil komplikasyonların da küresel sağlık sorunu haline geldiği görülmüştür. Bu komplikasyonlar arasında en dikkat çekici olanlardan biri diyabetik nöropatidir. Diyabetik nöropatinin mekanizma temelli ve semptomatik konvansiyonel tedavileri incelendiğinde, bu durumdan muzdarip hastaların henüz yeterli tedaviye sahip olmadıkları görülmektedir. Mevcut durumda yeni ilaç arayışlarının önemli olduğu görülmektedir. Bu çalışmada, doğal kaynakların diyabetik nöropati tedavisindeki rolünün ekstreler ve sekonder bileşikler bazında derlenmesi amaçlanmıştır. Sonuç ve Tartışma: Doğal kaynaklar, diyabet ve komplikasyonlarının tedavisinde yeni ajanların geliştirilmesi açısından önemlidir. Yapılan kapsamlı literatür araştırmasında, başta flavonoitler olmak üzere fenolik karakterli biyoaktif metabolitlerin etkili sonuçlar sağladığı görülmüştür. Literatür verileri fenolik bileşikler ile antioksidan mekanizmalar arasındaki ilişkinin önemini ortaya çıkarmaktadır. Diyabetik nöropati tedavisine yönelik yapılan preklinik ve klinik araştırmalar sonucu tespit edilen ve sekonder metabolitler açısından fenoliklerce zengin türler ülkemizde geniş yayılış göstermektedir. Türkiye florasındaki taksonların bu alandaki ilaç eczacılık araştırma-geliştirme çalışmaları için iyi bir kaynak oluşturacağı düşünülmektedir.

Anahtar Kelimeler

• Diyabetik nöropati
• doğal kaynaklar
• flavonoitler
• hesperidin
• kersetin

Kaynakça

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