ÇOKLU İLAÇ YÜKLÜ 3D BASKILI DOZAJ FORMLARINA ODAKLANAN 3D BASKI TEKNOLOJİLERİNE GENEL BAKIŞ

Öz

Amaç: Bu derleme, 2015 yılında onaylanan ilk üç boyutlu baskılı dozaj formu olan Spritam®’dan bu yana, üç boyutlu baskılama (3DP) teknolojileriyle üretilen çoklu ilaç yüklü dozaj formlarına odaklanmaktadır. Sonuç ve Tartışma: 3DP sayesinde, tek bir dozaj formunda birden fazla ilacın entegrasyonu mümkün hale gelmiş olup, bu durum dozaj, ilaç salım profilleri ve geometrik yapılar açısından önemli bir tasarım esnekliği sağlamaktadır. Bu formülasyonlar, farklı ilaçları tek bir ünitede birleştirerek önemli bir tasarım esnekliği sunar ve özellikle birden fazla ilaç kullanımını gerektiren hastalıklar için tedavi stratejilerini optimize etme potansiyeline sahiptir. Geniş literatür araştırması, çok bölmeli kapsüller veya tabletler, farklı salım kinetiği gösteren çift katmanlı veya çok katmanlı tabletler ve çekirdek/kabuk yapılı tabletler gibi çeşitli geometrilere sahip 3D baskılı dozaj formları elde etmek için en yaygın kullanılan yöntemin Eriyik Birikim Modelleme (FDM) olduğunu ortaya koymaktadır. Çoklu ilaç yüklü 3D baskılı dozaj formları, sabit doz kombinasyonlarını kişiselleştirme noktasında önemli bir potansiyel sunmaktadır ve kişiselleştirilmiş tıbbın ilerletilmesinde ve polifarmasiye bağlı terapötik sonuçların iyileştirilmesinde umut vadeden bir araç olarak değerlendirilmektedir. Bu yenilikçi yaklaşım, terapötik etkinliği artırabilir, yan etki riskini azaltabilir ve hasta uyumunu iyileştirebilir. Mevcut araştırmaların ilerlemesiyle birlikte, bu formülasyonlar ilaç geliştirme ve tedavi stratejilerinin geleceği açısından umut verici bir yön sunmaktadır.

Anahtar Kelimeler

• 3DP teknolojisi
• çoklu ilaç yüklü 3D çıktılar
• kişiselleştirilmiş tıp
• polipiller

AN OVERVIEW OF 3D PRINTING TECHNOLOGIES FOCUSING MULTIDRUG-LOADED 3D PRINTED DOSAGE FORMS

Öz

Objective: This review focuses on multidrug-loaded dosage forms produced with three-dimensional printing (3DP) technologies since the confirmation of Spritam®, the first 3D printed dosage form, in 2015. Result and Discussion: The integration of multiple drugs within a single dosage form through 3DP offers substantial flexibility in design, allowing for the customization of dosage, drug release profiles, and geometric structures. These formulations offer significant design flexibility by combining different drugs in a single unit, and have the potential to optimize treatment strategies, especially for diseases requiring multiple drug use. The wide literature search reveals that the most commonly used method is Fused Deposition Modeling (FDM) to obtain 3D printed dosage forms with various geometries, such as multi-compartment capsules or tablets, bi-layered or multi-layered tablets exhibiting different release kinetics, and core/shell structured tablets. Multidrug-loaded 3D-printed dosage forms have significant potential for individualizing fixed-dose combinations and have become a promising tool for advancing personalized medicine and improving therapeutic outcomes for polypharmacy. This innovative approach can optimize therapeutic efficacy, reduce side effects, and improve patient compliance. As research continues to expand, these formulations represent a promising direction for the future of drug development and treatment strategies.

Anahtar Kelimeler

• 3DP technology
• multidrug-loaded 3D printlets
• personalized medicine
• polypills

Kaynakça

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