A THERAPEUTIC INSIGHTS ON EMERGING INDOLE-3-ACETIC ACID DERIVATIVES

Öz

Objective: Auxin or indole-3-acetic acid (IAA) is a pivotal phytohormone that regulates plant growth, development, and environmental responses Indole-3-acetic acid (IAA), a small molecule originated early in evolution in organisms like blue-green algae (cyanobacteria). Structurally, IAA consists of a carboxylic side chain and an indole ring. IAA exhibits unique biological behaviors such as dimer formation stabilized by hydrogen bonding. It is synthesized by plants and certain bacteria including Pseudomonas, Rhizobium and Azospirillum, through complex, redundant biosynthetic pathways involving multiple intermediates and enzymes. These pathways demonstrate robustness and adapt ability, enabling compensation for disruptions. The indole-3-acetic acid derivatives were designed and studied numerously for their wide array of pharmacological actions. Therefore, derivatives of this moiety need to be studied for the identification of their diverse pharmacological actions, which will help the future medicinal chemists to a larger extent.

Result and Discussion: In this review study, the different derivatives of Indole-3-acetic acid were studied. The study highlights the synthetic and medicinal potential of indole-3-acetic acid and its indole-based analogues, exploring their role in advancing therapeutic and biological applications.

Anahtar Kelimeler

• Anticancer
• antidiabetic
• antimicrobial
• antioxidant
• indole-3-acetic acid

Proje Numarası

0

Etik Beyan

There is no human or animal subject were utilized while carrying out this study.

İNDOL-3-ASETİK ASİT TÜREVLERİ HAKKINDA TERAPÖTİK BİR BAKIŞ AÇISI

Öz

Amaç: Oksin veya indol-3-asetik asit (IAA), bitki büyümesini, gelişimini ve çevresel tepkileri düzenleyen temel bir fitohormondur İndol-3-asetik asit (IAA), mavi-yeşil algler (siyanobakteriler) gibi organizmalarda evrimin erken dönemlerinde ortaya çıkan küçük bir moleküldür. Yapısal olarak, IAA bir karboksilik yan zincir ve bir indol halkasından oluşur. IAA, hidrojen bağıyla stabilize edilen dimer oluşumu gibi benzersiz biyolojik davranışlar sergiler. Bitkiler ve Pseudomonas, Rhizobium ve Azospirillum dahil olmak üzere belirli bakteriler tarafından, birden fazla ara ürün ve enzim içeren karmaşık, yedekli biyosentetik yollarla sentezlenir. Bu yollar, bozulmaların telafi edilmesini sağlayan sağlamlık ve uyum yeteneği gösterir. İndol-3-asetik asit türevleri, çok çeşitli farmakolojik etkileri için sayısız kez tasarlanmış ve incelenmiştir. Bu nedenle, bu grubun türevlerinin çeşitli farmakolojik etkilerinin belirlenmesi için incelenmesi gerekmektedir; bu, geleceğin tıbbi kimyacılarına daha büyük ölçüde yardımcı olacaktır.

Sonuç ve Tartışma: Bu derleme çalışmasında, İndol-3-asetik asidin farklı türevleri incelendi. Çalışma, indol-3-asetik asidin ve indol bazlı analoglarının sentetik ve tıbbi potansiyelini vurgulayarak, terapötik ve biyolojik uygulamaları ilerletmedeki rollerini araştırmaktadır.

Anahtar Kelimeler

• Antidiyabetik
• antikanser
• antimikrobiyal
• antioksidan
• indol-3-asetik asit

Proje Numarası

0

Kaynakça

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