ACNE VULGARIS TREATMENT AND RETINOIC ACID DERIVATIVES

Öz

Objective: Acne vulgaris is a common chronic inflammatory disease all over the world and affects people both physically and psychologically. Various antibiotics and retinoic acid derivatives are used in its treatment. The aim of the study is to examine retinoic acid derivatives, which are the basic building blocks of the treatment of this disease, and current studies aimed at reducing the side effects of these derivatives.

Result and Discussion: Retinoids and antibiotics are used as complementary agents in the treatment of acne vulgaris. While retinoids provide a long-term solution, antibiotics are used for short periods of time due to the development of resistance. Isotretinoin, the only systemically used retinoic acid derivative, is the only derivative that permanently affects the course of the disease in severe and resistant acne. Although the modifications made to improve these derivatives change the activity and selectivity, some side effects appear to persist. Therefore, optimising formulations that will minimise these side effects will increase the success of acne treatment.

Anahtar Kelimeler

• Acne vulgaris
• isotretinoin
• retinoic acid

AKNE VULGARİS TEDAVİSİ VE RETİNOİK ASİT TÜREVLERİ

Öz

Amaç: Akne vulgaris tüm dünyada sık karşılaşılan bir kronik enflamatuar hastalık olup insanları hem fiziksel hem de psikolojik açıdan etkilemektedir. Tedavisinde çeşitli antibiyotikler ve retinoik asit türevleri kullanılmaktadır. Çalışmadaki amaç bu hastalığın tedavisinin temel yapı taşı olan retinoik asit türevlerini ve bu türevlerin yan etkilerini azaltmaya yönelik yapılan güncel çalışmaları incelemektir.

Sonuç ve Tartışma: Akne vulgaris tedavisinde retinoidler ve antibiyotikler birbirini tamamlayan ajanlar olarak kullanılmaktadır. Retinoidler uzun vadeli çözüm sunarken antibiyotikler direnç gelişimi nedeniyle kısa süreli kullanılmaktadır. Sistemik olarak kullanılan tek retinoik asit türevi olan izotretinoin, şiddetli ve dirençli aknede hastalığın seyrine kalıcı olarak etki eden tek türevdir. Bu türevleri iyileştirmeye yönelik yapılan modifikasyonlar her ne kadar aktifliği ve seçiciliği değiştirse de bazı yan etkilerin devam ettiği görülmektedir. Bu nedenle bu yan etkileri minimuma indirecek formülasyonların optimize edilmesi akne tedavisindeki başarıyı arttıracaktır.

Anahtar Kelimeler

• Akne vulgaris
• izotretinoin
• retinoik asit

Destekleyen Kurum

Bu derleme çalışması hiçbir maddi destek alınmadan, Çukurova Üniversitesi Eczacılık Fakültesi bünyesinde gerçekleştirilmiştir.

Kaynakça

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