AN INNOVATIVE APPROACH TO PEDIATRIC FORMULATIONS: THREE-DIMENSIONAL (3D) PRINTING TECHNOLOGY

Öz

Objective: This review aims to evaluate the role of three-dimensional (3D) printing technology in the design of pediatric drug formulations, which needs it addresses for this population, and study examples of various drug formulations produced for this purpose.

Result and Discussion: Various anatomical and physiological differences in pediatric population affect pharmacokinetics of drugs. Since many medicines used in children are not commercially available in age- or weight-adjusted or divisible doses, dosage modification is often required. In such cases, solid dosage forms such as tablets or capsules are commonly dispersed or dissolved in a liquid to facilitate administration. However, this practice may compromise product stability and safety; inaccurate dosing can increase the risk of adverse drug reactions or change drug bioavailability. Using  3D  printing  technology  with various design software, personalized dosage forms with complex designs can be developed. To date, studies conducted using this technology indicate that dose flexibility for pediatric applications can be achieved by modifying printing parameters; that dosage forms with low doses, improved organoleptic properties, and increased bioavailability can be produced; and that 3D printing technology may be used as an important innovation in pediatric drug manufacturing in community and hospital pharmacies in the future.

Anahtar Kelimeler

• 3D printing technology
• pediatric medicine
• pediatry
• personalized treatment

PEDİATRİK FORMÜLASYONLARA YENİLİKÇİ BİR YAKLAŞIM: ÜÇ BOYUTLU (3B) BASKI TEKNOLOJİSİ

Öz

Amaç: Bu derlemede üç boyutlu (3B) baskı teknolojisinin pediatrik ilaç formülasyonlarının tasarımındaki yeri, bu popülasyona yönelik hangi ihtiyaçlara çözüm olduğu ve bu amaçla üretilmiş çeşitli ilaç şekillerine ait çalışma örneklerinin değerlendirilmesi amaçlanmıştır.

Sonuç ve Tartışma: Pediatrik popülasyondaki çeşitli anatomik ve fizyolojik farklılıklar ilacın farmakokinetiğini etkilemektedir. Çocukların tedavisinde kullanılan birçok ilacın yaşa ve kiloya göre çeşitlendirilmiş ya da bölünebilir dozu piyasada bulunmadığından doz ayarlaması gerektiğinde tablet, kapsül vb. ilaç şekillerinin bir sıvı içerisinde dağıtılarak veya çözülerek daha kolay kullanabileceği hale getirilmesi yaygın bir uygulamadır. Bu durum ürünün stabilitesini ve güvenliğini bozar, hatalı dozlamalar advers ilaç reaksiyonları riskini artırabilir veya ilacın biyoyararlanımını değiştirir. 3B baskı teknolojisi ile çeşitli tasarım programları kullanılarak kişiye özel kompleks tasarımlı ürünler geliştirilebilir. Günümüze kadar bu teknoloji ile yapılan çalışmalar baskı parametreleri değiştirilerek pediatrik uygulamalar için doz esnekliği sağlanabileceğini, küçük dozlarda, organoleptik özellikleri iyileştirilmiş, biyoyararlanımı artırılmış ilaç şekillerinin üretilmesinin mümkün olacağını ve 3B baskı teknolojisinin gelecekte toplum ve hastane eczanelerinde pediatrik ilaç üretiminde önemli bir yenilik olarak kullanılabileceğini göstermektedir.

Anahtar Kelimeler

• 3B baskı teknolojisi
• kişiselleştirilmiş tedavi
• pediatri
• pediatrik ilaç

Kaynakça

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