Araştırma Makalesi

ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET

Sayı: Advanced Online Publication Erken Görünüm Tarihi: 15 Mayıs 2026
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ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET

Öz

Objective: Cinnamon has been widely used as a popular spice. The cheaper and more commonly found Cassia cinnamon contains high amounts of coumarin, a naturally occurring hepatotoxic component. The coumarin content added to food products for flavoring purposes is regulated by the European Food Safety Authority. Therefore, it is important to know the amount of coumarin in commercial cinnamon spices and to determine the consumption amounts.

Material and Method: In this study, 22 samples labeled as cinnamon in stick and ground form in the Turkish markets were analyzed using LC-qTOF-MS. The analyzed coumarin content was compared to the European Union limit, which is the tolerable daily intake set by the European Food Safety Authority at 0.1 mg coumarin/kg body weight.

Result and Discussion: The results showed that all but one of the samples contained coumarin. Considering the daily intake limits of coumarin, which are a maximum of 1.5 mg for a 15 kg child and 6 mg for a 60 kg adult, it was found that most samples exceeded these limits. In addition to the amount of coumarin and daily intake that people should be cautious about when consuming cinnamon, the type of cinnamon, whether in stick or powder form, should also be indicated on cinnamon spice packages.

Anahtar Kelimeler

Kaynakça

  1. 1. Yazdanpanah, Z., Azadi-Yazdi, M., Hooshmandi, H., et al. (2020). Effects of cinnamon supplementation on body weight and composition in adults: A systematic review and meta-analysis of controlled clinical trials. Phytotherapy Research, 34(3), 448-463. [CrossRef]
  2. 2. Bandara, T., Uluwaduge, I., Jansz, E.R. (2012). Bioactivity of cinnamon with special emphasis on diabetes mellitus: A review. International Journal of Food Sciences and Nutrition, 63, 380-386. [CrossRef]
  3. 3. Rafehi, H., Ververis, K., Karagiannis, T.C. (2012). Controversies surrounding the clinical potential of cinnamon for the management of diabetes. Diabetes, Obesity and Metabolism, 14, 493-499. [CrossRef]
  4. 4. Sierra-Puente, S., Abadi-Alfie, S., Arakanchi-Altaled, K., et al. (2020). Cinammon (Cinnamomum spp.) and type 2 diabetes mellitus. Current Topics in Nutraceutical Research, 18(3), 247-255.
  5. 5. World Health Organization. WHO. (1999). Cortex Cinnamomi. WHO Monographs on Selected Medicinal Plants,1, Geneva, 95-105.
  6. 6. Ravindran, P.N., Nirmal-Babu, K. (2004). Introduction. Eds.: Ravindran, P.N., Nirmal-Babu, K., Shylaja, M. Cinnamon and Cassia: The Genus Cinnamomum, CRC Press, Boca Raton, 1-13.
  7. 7. Wang, Y.H., Avula, B., Dhammika Nanayakkara, N.P., et al. (2013). Cassia cinnamon as a source of coumarin in cinnamon-flavored food and food supplements in the United States. Journal of Agricultural and Food Chemistry, 61, 4470-4476. [CrossRef]
  8. 8. Sproll, C., Ruge, W., Andlauer, C., et al. (2008). HPLC analysis and safety assessment of coumarin in foods. Food Chemistry, 109, 462-469. [CrossRef]

Ayrıntılar

Birincil Dil

İngilizce

Konular

Farmasotik Botanik

Bölüm

Araştırma Makalesi

Erken Görünüm Tarihi

15 Mayıs 2026

Yayımlanma Tarihi

-

Gönderilme Tarihi

16 Ağustos 2025

Kabul Tarihi

11 Nisan 2026

Yayımlandığı Sayı

Yıl 2026 Sayı: Advanced Online Publication

Kaynak Göster

APA
Diker, N. Y., Kaplan, O., Ünal Özen, G., Çelebier, M., Büyüktuncer Demırel, Z., & Çankaya, İ. İ. (2026). ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET. Journal of Faculty of Pharmacy of Ankara University, Advanced Online Publication. https://doi.org/10.33483/jfpau.1762483
AMA
1.Diker NY, Kaplan O, Ünal Özen G, Çelebier M, Büyüktuncer Demırel Z, Çankaya İİ. ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET. Ankara Ecz. Fak. Derg. 2026;(Advanced Online Publication). doi:10.33483/jfpau.1762483
Chicago
Diker, Neziha Yağmur, Ozan Kaplan, Gurbet Ünal Özen, Mustafa Çelebier, Zehra Büyüktuncer Demırel, ve İffet İrem Çankaya. 2026. “ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET”. Journal of Faculty of Pharmacy of Ankara University, sy Advanced Online Publication. https://doi.org/10.33483/jfpau.1762483.
EndNote
Diker NY, Kaplan O, Ünal Özen G, Çelebier M, Büyüktuncer Demırel Z, Çankaya İİ (01 Mayıs 2026) ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET. Journal of Faculty of Pharmacy of Ankara University Advanced Online Publication
IEEE
[1]N. Y. Diker, O. Kaplan, G. Ünal Özen, M. Çelebier, Z. Büyüktuncer Demırel, ve İ. İ. Çankaya, “ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET”, Ankara Ecz. Fak. Derg., sy Advanced Online Publication, May. 2026, doi: 10.33483/jfpau.1762483.
ISNAD
Diker, Neziha Yağmur - Kaplan, Ozan - Ünal Özen, Gurbet - Çelebier, Mustafa - Büyüktuncer Demırel, Zehra - Çankaya, İffet İrem. “ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET”. Journal of Faculty of Pharmacy of Ankara University. Advanced Online Publication (01 Mayıs 2026). https://doi.org/10.33483/jfpau.1762483.
JAMA
1.Diker NY, Kaplan O, Ünal Özen G, Çelebier M, Büyüktuncer Demırel Z, Çankaya İİ. ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET. Ankara Ecz. Fak. Derg. 2026. doi:10.33483/jfpau.1762483.
MLA
Diker, Neziha Yağmur, vd. “ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET”. Journal of Faculty of Pharmacy of Ankara University, sy Advanced Online Publication, Mayıs 2026, doi:10.33483/jfpau.1762483.
Vancouver
1.Neziha Yağmur Diker, Ozan Kaplan, Gurbet Ünal Özen, Mustafa Çelebier, Zehra Büyüktuncer Demırel, İffet İrem Çankaya. ASSESSMENT OF COUMARIN LEVELS IN CINNAMON SPICES AVAILABLE IN THE TURKISH MARKET. Ankara Ecz. Fak. Derg. 01 Mayıs 2026;(Advanced Online Publication). doi:10.33483/jfpau.1762483

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.