TR
EN
SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS
Öz
Objective: A new spectrophotometric method has been developed for the determination of metoprolol
tartrate in pure and dosage forms.
Material and Method: This method is based on the reaction between metoprolol tartrate and 2,3-
dichloro-1,4-naphthoquinone in dimethylformamide (DMF) medium to form the colored reaction product with
maximum absorption at 493 nm. Optimum conditions to carry out the reaction such as concentration of reagent,
temperature and heating time were carefully studied and optimized. Beer’s law was performed at the
concentration range of 18.00-28.00 mg/100 ml. The proposed method is valid according to the validation
requirements of the State Pharmacopoeia of Ukraine.
Result and Discussion: The results of the study show that the procedure is accurate, simple and relevant
for application at the quality control laboratories for dosage forms
Anahtar Kelimeler
Kaynakça
- Kovalenko, V., & Dorohoy, A. (2016). Sertsevo-sudynni khvoroby: medychno-sotsialʹne znachennya ta stratehiya rozvytku kardiolohiyi v Ukrayini [Cardiovascular disease: medical and social significance and the strategy of cardiology development in Ukraine]. Ukrayins'kyy kardiolohichnyy zhurnal, 4(3), 5-14.
- Buchhorn, R., & Borst, M. (2017). The History and Future of Beta Blockers in Heart Failure Treatment in Children and Adults. Medical Research Archives, 5(9), 1-11.
- Mashkovskiy, M. (2012). Lekarstvennye sredstva [Medicine remedies]. Moscow: Novaya Volna.
- European pharmacopoeia (2011). (7th ed.). Strasbourg: Council of Europe.
- British Pharmacopoeia (2009). London: The Stationery Office.
- Nabil A. F., A., & Eman. M., S. (2015). Spectrophotometric determination of metoprolol in pharmaceutical formulation by charge transfer complexation. International Journal Of Chemical Studies, 3(2), 24-29.
- Cesme, M., Tarinc, D., & Golcu, A. (2011). Spectrophotometric Determination of Metoprolol Tartrate in Pharmaceutical Dosage Forms on Complex Formation with Cu(II). Pharmaceuticals, 4(12), 964-975. http://dx.doi.org/10.3390/ph4070964
- Hussain, S., R.Munjewar, R., & Farooqui, M. (2012). Development and Validation of a Simultaneous HPLC Method for Quantification of Amlodipine Besylate and Metoprolol Tartrate inTablets. Journal Of Pharmascitech, 1(2), 1-5.
Ayrıntılar
Birincil Dil
İngilizce
Konular
-
Bölüm
Araştırma Makalesi
Yayımlanma Tarihi
31 Ocak 2018
Gönderilme Tarihi
27 Mart 2018
Kabul Tarihi
-
Yayımlandığı Sayı
Yıl 2018 Cilt: 42 Sayı: 1
APA
Donchenko, A., & Vasyuk, S. (2018). SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS. Journal of Faculty of Pharmacy of Ankara University, 42(1), 33-42. https://izlik.org/JA99DC74SW
AMA
1.Donchenko A, Vasyuk S. SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS. Ankara Ecz. Fak. Derg. 2018;42(1):33-42. https://izlik.org/JA99DC74SW
Chicago
Donchenko, Anastasiia, ve Svitlana Vasyuk. 2018. “SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS”. Journal of Faculty of Pharmacy of Ankara University 42 (1): 33-42. https://izlik.org/JA99DC74SW.
EndNote
Donchenko A, Vasyuk S (01 Ocak 2018) SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS. Journal of Faculty of Pharmacy of Ankara University 42 1 33–42.
IEEE
[1]A. Donchenko ve S. Vasyuk, “SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS”, Ankara Ecz. Fak. Derg., c. 42, sy 1, ss. 33–42, Oca. 2018, [çevrimiçi]. Erişim adresi: https://izlik.org/JA99DC74SW
ISNAD
Donchenko, Anastasiia - Vasyuk, Svitlana. “SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS”. Journal of Faculty of Pharmacy of Ankara University 42/1 (01 Ocak 2018): 33-42. https://izlik.org/JA99DC74SW.
JAMA
1.Donchenko A, Vasyuk S. SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS. Ankara Ecz. Fak. Derg. 2018;42:33–42.
MLA
Donchenko, Anastasiia, ve Svitlana Vasyuk. “SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS”. Journal of Faculty of Pharmacy of Ankara University, c. 42, sy 1, Ocak 2018, ss. 33-42, https://izlik.org/JA99DC74SW.
Vancouver
1.Anastasiia Donchenko, Svitlana Vasyuk. SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS. Ankara Ecz. Fak. Derg. [Internet]. 01 Ocak 2018;42(1):33-42. Erişim adresi: https://izlik.org/JA99DC74SW