ALZHEİMER HASTALIĞININ GELİŞİMİNDE BİYOLOJİK AJANLARIN OLASI ETKİLERİ

Öz

Amaç: Bu derleme kapsamında, Alzheimer hastalığının genel özelliklerinden bahsedilecek; bu hastalığın patofizyolojisinde rol oynayabileceği bildirilen biyolojik ajanlardan ve bu konuda yapılmış çalışmalardan söz edilecektir.

Sonuç ve Tartışma: Dünya çapında artan nüfusa bağlı olarak yaşlı nüfusun artması Alzheimer hastalığının görülme sıklığının artmasına yol açmıştır. Son yıllarda, farklı demans türleri ve özellikle de Alzheimer hastalığı konusundaki bilimsel araştırmalar hızlanmıştır. Hastalığın multi-genetik nedenlerle ortaya çıkabileceği bilinmektedir. Ancak, birçok biyolojik ajana maruziyetin de Alzheimer hastalığının patofizyolojisinde rol oynayabileceği belirtilmektedir. Literatürde Herpes simplex virüs tip-1 (HSV-1), insan immünoyetmezlik virüsü 1 (HIV-1) ve Helicobacter pylori gibi enfeksiyon etkenlerinin ve vücutta endojen olarak bulunan prion proteinlerinin bu hastalığının gelişimine yol açabileceği belirtilmektedir. Diğer taraftan, diyabet gibi hastalıkların da Alzheimer hastalığının gelişimini hızlandırabileceğine dair araştırmalar bulunmaktadır. 

Anahtar Kelimeler

• Alzheimer hastalığı,Helicobacter pylori,Herpes simplex virüs tip-1 (HSV-1),İnsan immünoyetmezlik virüsü 1 (HIV-1)

THE POSSIBLE EFFECTS OF BIOLOGICAL AGENTS ON THE DEVELOPMENT OF ALZHEIMER’S DISEASE

Öz

Objective: In this review, we will mainly focus on the the general properties of Alzheimer’s disease and will also mention the biological agents that are suggested to play roles in the pathophysiology of Alzeheimer’s disease and the studies performed on these agents.

Result and Discussion: The increase in elderly population due to the increasing population worldwide has led to an increase in the prevalance of Alzheimer’s disease. In the last years, scientific studies on different types of dementia and particularly on Alzheimer’s disease have accelerated. It is known that this disease has multi-genetic grounds. However, exposure to several biological agents are also suggested to play roles in the pathophysiology of Alzheimer’s disease. There are studies in literature suggesting that infections like Herpes simplex virus tip-1 (HSV-1), human immunodeficiency virus type 1 (HIV-1), Helicobacter pylori and endogenous prion poteins can contribute to the development of this disease. On the other hand, there are studies suggesting that diseases like diabetes can expedite the development of Alzheimer’ss disease. 

Anahtar Kelimeler

• Alzheimer's disease,Helicobacter pylori,Herpes simplex virus type 1,human immunodeficiency virus type 1 (HIV-1)

Kaynakça

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