HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA

Öz

Objectives: The aim of the research is the histological study of the corrective effect of the compound potassium 2((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3yl)thio)acetate (PKR-173) with different antibiotics on the state of chicken's liver under infection by Pseudomonas aeruginosa.

Materials and Methods: The histological study was carried out on the levers of intact chickens (intact control); chickens that were infected by the strain of Pseudomonas aeruginosa (controlled pathology); chickens that had (before being infected by Pseudomonas aeruginosa) preventive input of the compound PKR-173 with the classic antibiotic Enrofloxacin or with Saroflox (undergoing research); or were input Thiotriazolin with the classic antibiotic Enrofloxacin.

Result and Discussion: As a result, it is stated, that preventive input of the compound PKR-173 with reseachable antibiotic Saroflox, as well as with classic antibiotic Enrofloxacin and Thiotriazolin with antibiotic Enrofloxacin, to chickens infected with pseudomonas aeruginosa, prevents from chickens' livers developng stereotypical morphological changes characteristic of nonspecific reactive hepatitis. Analysis of quantitative characteristics of pathological process that developed in chicken's liver infected with pseudomonas aeruginosa, and the corrective influence of reseached methods showed that the compound PKR-173 with antibiotic Saroflox believably lowers displays of all signs of pathology compared to the controlled pathology. 

Anahtar Kelimeler

• 1.2.4-triazole
• hepatitis
• hepatoprotective effect
• pseudomonosic infection
• Saroflox.

PSEUDOMONAS AERUGINOSA İLE ENFEKTE EDİLMİŞ CİVCİVLERİN KARACİĞERİNE POTASYUM 2-((4-AMİNO-5-(MORFOLİNOMETİL)-4H-1,2,4-TRİAZOL-3- İL)TİYO)ASETAT (PKR-173) BİLEŞİĞİNİN DÜZELTİCİ ETKİSİNİN HİSTOLOJİK OLARAK ARAŞTIRILMASI

Öz

Amaç: Araştırmanın amacı, potasyum 2-((4-amino-5-(morfolinometil)-4H-1,2,4-triazol-3-il)tiyo)asetat (PKR-173) bileşiğinin farklı antibiyotikler ile birlikte Pseudomonas aeruginosa ile enfekte edilmiş civcivlerin karaciğerine düzeltici etkisinin histolojik olarak incelenmesidir.

Gereç ve Yöntem: Histolojik araştırma, sağlam civcivler (kontrol), Pseudomonas aeruginosa ile enfekte edilmiş civcivler (kontrol edilen patoloji), (Pseudomonas aeruginosa ile enfekte edilmeden önce) PKR-173 bileşiği ile Enrofloxacin veya Saroflox gibi klasik antibiyotik yada tiotiazolin ile Enrofloxacin antibiyotiği verilen civcivlerin karaciğeri üzerinde yapılmıştır.

Sonuç ve Tartışma: Araştırmaların sonucunda; araştırılan antibiyotik olan Saroflox ile PKR-173 bileşiğinin ve önleyici bir şekilde Pseudomonas aeruginosa ile enfekte edilmiş civcivlere uygulanan Enrofloxacin ve Thiotriazolin- Enrofloxacin gibi klasik antibiyotiklein, nonspesifik reaktif hepatite özgü olan karaciğerdeki standart morfolojik değişiklikleri önlediği tespit edilmiştir. Pseudomonas aeruginosa ile enfekte edilmiş civcivlerin karaciğerinde gelişen patolojik sürecin kantitatif özelliklerinin analizi ve düzeltici etkisi araştırılan metot, Saroflox antibiyotiği ile PKR-173 bileşiğinin, kontroldeki patolojiye kıyasla patolojinin bütün belirtilerini azalttığını göstermiştir.

Anahtar Kelimeler

• hepatit
• hepatoprotektif etki
• 1.2.4-triazol
• pseudomonas enfeksiyonu
• saroflox

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