APPLICATIONS OF MINIATURIZED AND PORTABLE NEAR INFRARED (NIR), FOURIER TRANSFORM INFRARED (FT-IR) AND RAMAN SPECTROMETERS FOR THE INSPECTION AND CONTROL OF PHARMACEUTICAL PRODUCTS

Yıl 2020, , 188 - 203, 31.01.2020

Abdullahi Garba Usman Umar Muhammad Ghali Selin Işık

https://doi.org/10.33483/jfpau.599077

Cited By: 6

Öz

Objective: In
this review, the wide range of different applications of portable and
miniaturized Fourier transform infrared (FT-IR), near-infrared (NIR), and Raman
spectrometers for quality control, assessment and inspection of pharmaceutical
products are discussed. In regard to counterfeiting, these portable
spectrometers are utilized for vibrational and scattering spectroscopies in the
identification of counterfeits, adulterated, fraudulent, falsified and
substandard pharmaceutical products which are becoming significant problems and
a danger to general well-being, particularly in the developing nations.

Meterial and Method: Totally
74 different scientific articles and books were researched and reviewed to
explain the applications of miniaturized and portable near infrared (NIR), Fourier
transform Infrared (FT-IR) and Raman spectrometers for the inspection and
control of pharmaceutical products from past to nowadays.

Result and Discussion: Adulterated
pharmaceutical products have become the greatest threat for developing
countries. This problem can reduce the confidence for pharmaceutical products. The
application of mentioned portable devices for determinations the quality
control of pharmaceutical product, enables the techniques to be more
accessible, quick, accurate, simple, precise, robust and more importantly,
efficient.

Anahtar Kelimeler

Infrared (NIR) and Raman spectrometers, pharmaceutical products, Portable Fourier Transform Infrared (FT-IR), quality control

MİNYATÜRE EDİLMİŞ VE PORTATİF YAKIN KIZIL ÖTESİ (NIR), FOURIER DÖNÜŞÜMLÜ KIZILÖTESİ (FTIR) ve RAMAN SPEKTROMETRELERİNİN FARMASÖTİKLERİN DENETİMİ VE KONTROLÜNDEKİ UYGULAMALARI

Öz

Amaç: Bu derlemede, farmasötik ürünlerin
kalite kontrollerinin değerlendirilmesi ve belirlenmesi için portatif ve
minyatür Fourier transform infrared (FT-IR), yakın kızıl ötesi (NIR) ve Raman
spektrometrelerin geniş uygulama alanları tartışılmıştır. Farmasötik ürünlerde
yapılan sahtecilikler sonucunda, genel refah için bir tehlike haline gelen
taklit, hileli, tahrif edilmiş ve standart altı farmasötik ürünlerin
belirlenmesinde kullanılan bu portatif spektrometreler, titreşimsel ve saçılma
spektroskopileri için kullanılmaktadır.

Gereç ve Yöntem: Çeşitli
bilimsel makaleler ve kitaplar incelenmiş olup, geçmişten günümüze kadar olan
süreçte, Fourier
transform infrared (FT-IR), yakın kızıl ötesi (NIR) ve Raman spektrometrelerin farmasötik ürünlerin kalite kontrolü ve denetimi ile ilgili
uygulamaları derlenmiştir.

Sonuç ve Tartışma: Hileli
farmasötik ürünler özellikle gelişmekte olan ülkeler için önemli bir tehdit
haline gelmiştir. Bu problem, farmasötik ürünlere olan güveni
azaltabilmektedir. Bu
makalede bahsi geçen  portatif cihazların
uygulanması, fitöfarmasötiklerin kalite kontrolünde tekniklerin daha
erişilebilir, hızlı, doğru, basit, hassas, sağlam ve daha da önemlisi, verimli
olmasını sağlamaktadır.

Anahtar Kelimeler

Denetim, farmasötik ürünler, kalite kontrol, taşınabilir Fourier dönüşümlü infrared (FTIR) spektroskopisi, Yakın infrared (NIR) ve Raman Spektrometresi

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