APPLICATIONS OF MINIATURIZED AND PORTABLE NEAR INFRARED (NIR), FOURIER TRANSFORM INFRARED (FT-IR) AND RAMAN SPECTROMETERS FOR THE INSPECTION AND CONTROL OF PHARMACEUTICAL PRODUCTS

Öz

Objective: In this review, the wide range of different applications of portable and miniaturized Fourier transform infrared (FT-IR), near-infrared (NIR), and Raman spectrometers for quality control, assessment and inspection of pharmaceutical products are discussed. In regard to counterfeiting, these portable spectrometers are utilized for vibrational and scattering spectroscopies in the identification of counterfeits, adulterated, fraudulent, falsified and substandard pharmaceutical products which are becoming significant problems and a danger to general well-being, particularly in the developing nations.

Meterial and Method: Totally 74 different scientific articles and books were researched and reviewed to explain the applications of miniaturized and portable near infrared (NIR), Fourier transform Infrared (FT-IR) and Raman spectrometers for the inspection and control of pharmaceutical products from past to nowadays.

Result and Discussion: Adulterated pharmaceutical products have become the greatest threat for developing countries. This problem can reduce the confidence for pharmaceutical products. The application of mentioned portable devices for determinations the quality control of pharmaceutical product, enables the techniques to be more accessible, quick, accurate, simple, precise, robust and more importantly, efficient.

Anahtar Kelimeler

• Infrared (NIR) and Raman spectrometers,pharmaceutical products,Portable Fourier Transform Infrared (FT-IR),quality control

MİNYATÜRE EDİLMİŞ VE PORTATİF YAKIN KIZIL ÖTESİ (NIR), FOURIER DÖNÜŞÜMLÜ KIZILÖTESİ (FTIR) ve RAMAN SPEKTROMETRELERİNİN FARMASÖTİKLERİN DENETİMİ VE KONTROLÜNDEKİ UYGULAMALARI

Öz

Amaç: Bu derlemede, farmasötik ürünlerin kalite kontrollerinin değerlendirilmesi ve belirlenmesi için portatif ve minyatür Fourier transform infrared (FT-IR), yakın kızıl ötesi (NIR) ve Raman spektrometrelerin geniş uygulama alanları tartışılmıştır. Farmasötik ürünlerde yapılan sahtecilikler sonucunda, genel refah için bir tehlike haline gelen taklit, hileli, tahrif edilmiş ve standart altı farmasötik ürünlerin belirlenmesinde kullanılan bu portatif spektrometreler, titreşimsel ve saçılma spektroskopileri için kullanılmaktadır.

Gereç ve Yöntem: Çeşitli bilimsel makaleler ve kitaplar incelenmiş olup, geçmişten günümüze kadar olan süreçte, Fourier transform infrared (FT-IR), yakın kızıl ötesi (NIR) ve Raman spektrometrelerin farmasötik ürünlerin kalite kontrolü ve denetimi ile ilgili uygulamaları derlenmiştir.

Sonuç ve Tartışma: Hileli farmasötik ürünler özellikle gelişmekte olan ülkeler için önemli bir tehdit haline gelmiştir. Bu problem, farmasötik ürünlere olan güveni azaltabilmektedir. Bu makalede bahsi geçen  portatif cihazların uygulanması, fitöfarmasötiklerin kalite kontrolünde tekniklerin daha erişilebilir, hızlı, doğru, basit, hassas, sağlam ve daha da önemlisi, verimli olmasını sağlamaktadır.

Anahtar Kelimeler

• Denetim,farmasötik ürünler,kalite kontrol,taşınabilir Fourier dönüşümlü infrared (FTIR) spektroskopisi,Yakın infrared (NIR) ve Raman Spektrometresi

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