HARPAGOPHYTUM PROCUMBENS VE FİTOTERAPİDE KULLANIMI

Öz

Amaç: Bu derlemede, Harpagophytum procumbens ile ilgili genel bilgi verilip analjezik ve antienflamatuvar aktiviteleri üzerinde yapılmış in vitro, in vivo ve klinik çalışma bulguları sunulacaktır.

Sonuç ve Tartışma: H. procumbens kökleri Güney Afrika’da geleneksel halk tıbbında, romatizma ve ağrı tedavisinde uzun yıllardan beridir kullanılmaktadır. Günümüzde, standardize edilmiş kök ekstrelerinin (%1 harpagozit içerir) antienflamatuvar etkilere sahip olmasından dolayı osteoartrit hastalarında akılcı fitoterapi uygulamaları kapsamında kullanılmaktadır. Harpagozitin, nükleer faktör-kappa B’yi inhibe ederek lipopolisakkarit kaynaklı indüklenebilir nitrik oksit sentaz ve siklooksijenaz-2 ekspresyonu üzerinde inhibisyon sağlayarak antienflamatuvar etki gösterdiği tespit edilmiştir. Ayrıca standardize ekstreler, kıkırdak degredasyonunda anahtar rol oynayan matriks metalloproteinaz ve elastaz enzimlerini inhibe ederek kondroprotektif etkiler göstermektedir. Osteoartrit hastalarında minimum 2-3 ay kullanılması gerektiği önerilen ekstrenin, herhangi bir ciddi ilaç etkileşmesi oluşturmadığı da belirtilmektedir. Kanıta dayalı fitoterapi uygulamaları açısından; standardize H. procumbens kök ekstrelerinin osteoartritli hastalarda kullanımı ile ilgili yapılmış klinik çalışmalar mevcuttur ve çalışmalar devam etmektedir.

Anahtar Kelimeler

• Fitoterapi
• Harpagophytum procumbens
• osteoartrit
• şeytan pençesi

HARPAGOPHYTUM PROCUMBENS AND USE IN PHYTOTHERAPY

Öz

Objective: In this review, general information about Harpagophytum procumbens will be given and findings of in vitro, in vivo and clinical studies on analgesic and anti-inflammatory activities will be presented.

Result and Discussion: For many years, H. procumbens roots have been used to treat rheumatism and pain in traditional folk medicine in South Africa. Today, it is used within the scope of rational phytotherapy applications in osteoarthritis patients, since its standardized root extracts (containing 1% harpagozite) have anti-inflammatory effects. It has been found that harpagozite has an anti-inflammatory effect by inhibiting nuclear factor-kappa B, providing inhibition on the expression of lipopolysaccharide-inducible nitric oxide synthase and cyclooxygenase-2. In addition, standardized extracts show chondroprotective effects by inhibiting matrix metalloproteinase and elastase enzymes, which play a key role in cartilage degredation. It is also stated that the extract, which should be used for a minimum of 2-3 months in patients with osteoarthritis, does not cause any serious drug interaction. In terms of evidence-based phytotherapy applications; there are clinical studies on the use of standardized H. procumbens root extracts in patients with osteoarthritis, and studies are ongoing.

Anahtar Kelimeler

• Phytotherapy
• Harpagophytum procumbens
• osteoarthritis
• devil’s claw

Kaynakça

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