ORAL MUKOZİT TEDAVİSİ İÇİN METRONİDAZOL İÇEREN MUKOADEZİF-TERMOSENSİTİF BUCCAL JELİN GELİŞTİRİLMESİ VE KARAKTERİZASYONU

Öz

Amaç: Bu çalışmada oral mukozit tedavisi için bukkal mukoza sıcaklığında hızla jelleşebilen, metronidazol içeren mukoadhesif-termosensitif jel formülasyonu hazırlanması ve karakterize edilmesi amaçlanmıştır.

Gereç ve Yöntem: Bu çalışmada, belirli konsantrasyonlarda poloksamer 407 (P407), poloksamer 188 (P188) ve hidroksipropil metilselüloz (HPMC) kombinasyonları, bukkal mukozada jel oluşturmak için kullanılmıştır. Optimum formülasyonlar hazırlanan formülasyonların jelleşme süresi ve jelleşme sıcaklığı ölçülerek seçilmiştir. Seçilen formülasyonların sertlik, adhezif, kohezif, esneklik, püskürtülebilirlik, mukoadhezif ve salım özellikleri değerlendirilmiştir.

Sonuç ve Tartışma: Sonuçlar, 33 °C'de hızla jel formuna dönüşen F1 ve F3 formülasyonunun optimum formülasyonlar olabileceğini göstermiştir. Bu iki formülasyon 8 saat boyunca kontrollü salım göstermiştir. Doku profili analizi (TPA), mukoadhezyon ve püskürtülebilirlik çalışmaları, F1 formülasyonun, P407 (% 15), P188 (% 20) ve HPMC (% 5) kombinasyonu, bukkal mukoza için optimum formülasyon olduğunu göstermiştir. Sonuç olarak, metronidazole içeren mukoadhezif-ısıya duyarlı jeller oral mukozit tedavisinde iyi bir alternatif olabilir.

Anahtar Kelimeler

• Metronidazol
• mukoadhezif-ısıya duyarlı jel
• oral mukozit
• poloksamer

DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE-THERMOSENSITIVE BUCCAL GEL CONTAINING METRONIDAZOLE FOR THE TREATMENT OF ORAL MUCOSITIS

Öz

Objective: This study was aimed to develop and characterize, mucoadhesive-thermosensitive gel formulation containing metronidazole that can quickly gel at the buccal mucosa temperature for treatment of oral mucositis.

Material and Method: In this study, the combinations Poloxamer 407 (P407), Poloxamer 188 (P188) and Hydroxypropyl methylcellulose (HPMC) were used in certain concentrations to form a gel in buccal mucosa. Optimum formulations were selected by measuring the gelling time and gelling temperature of the formulations prepared. The hardness, adhesiveness, cohesiveness, resilience, sprayability, mucoadhesion and release properties of selected formulations were evaluated.

Result and Discussion: The results showed that F1 and F3 formulations, which quickly turn into gel form at 33 °C, could be the optimum formulations. These two formulations showed controlled release for 8 hours. Texture profile analysis (TPA), mucoadhesion studies and sprayability studies have shown that F1 formulation which the mixture of P407 (15%), P188 (20%) and HPMC (5%) is the optimum formulation for the buccal mucosa. In conclusion, mucoadhesive-thermosensitive gels containing metronidazole may be a good alternative in the treatment of oral mucositis.

Anahtar Kelimeler

• Metronidazole
• mucoadhesive-thermosensitive gel
• oral mucositis
• poloxamer

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