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MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER

Yıl 2021, , 344 - 378, 31.05.2021
https://doi.org/10.33483/jfpau.779015

Öz

Amaç: Mantarlar yüzyıllardan beri Uzakdoğu başta olmak üzere tüm dünyada gıda ve tıbbi amaçlı olarak kullanılmaktadır. Dünya genelinde kardiyovasküler hastalıklar, diyabet, kanser, obezite gibi hastalıkların hızla artması ve buna bağlı olarak tedavi ve bakım maliyetlerindeki artışlar, hem araştırıcılar hem de halk arasında alternatif tedavi yöntemlerine olan ilgiyi artmıştır.
Sonuç ve Tartışma: In vitro ve in vivo analizler ile klinik çalışmalar, başta Pleurotus spp, Lentinula edodes, Ganoderma lucidum, Grifolia frondosa gibi türler olmak üzere birçok mantar türünün yüzyıllardan beri süregelen geleneksel kullanımlarının doğruluğunu kanıtlamakta ve mantarlardan elde edilen ana biyoaktif bileşiklerin çeşitli hastalıkların önlenmesinde ve tedavisinde bir potansiyele sahip olduklarını göstermektedir. Bu derlemede mantarların, günümüzde sık rastlanan kanser, kardiyovasküler hastalıklar, diyabet gibi hastalıkların önlenmesi ve tedavisindeki potansiyellerini değerlendirmek amacıyla antitümör, antioksidan, antimikrobiyal, kolesterol düşürücü ve kan şekerini düzenleyici etkileri ile ilgili güncel in vitro, in vivo ve klinik çalışmalar derlenmiştir.

Kaynakça

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IN VITRO, IN VIVO AND CLINICAL ASSESMENT ABOUT THE MEDICINAL CHARACTERISTICS OF MUSHROOMS

Yıl 2021, , 344 - 378, 31.05.2021
https://doi.org/10.33483/jfpau.779015

Öz

Objective: For centuries, mushrooms have been used for food and medicinal purposes all over the world, especially in the Far East. The rapid increase of diseases such as cardiovascular diseases, diabetes, cancer, obesity worldwide and and increases in the costs of treatment and care of these diseases have increased the interest in alternative treatment methods among both researchers and the public.
Result and Discussion: In vitro, in vivo and clinical studies have proven the accuracy of many centuries-old traditional uses of mushrooms, especially species such as Pleurotus spp., Lentinula edodes, Ganoderma lucidum, Grifolia frondosa. Moreover, the studies show that that the main bioactive compounds derived from mushrooms have great potential in the prevention and treatment of various diseases. In this article, current in vitro, in vivo and clinical studies related to antitumor, antioxidant, antimicrobial, cholesterol lowering and blood sugar regulating properities of mushrooms were reviewed in order to evaluate the potentials in the prevention and treatment of diseases such as cancer, cardiovascular diseases and diabetes.

Kaynakça

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  • Referans139 Ng, S. H., Zain, M., Shazwan, M., Zakaria, F., Ishak, W., Rosli, W., Nizam, W. A. (2015). Hypoglycemic and antidiabetic effect of Pleurotus sajor-caju aqueous extract in normal and streptozotocin-induced diabetic rats. BioMed research international, 2015.
  • Referans140 Etewa, R. L., Mohamed, H. (2010). Hypoglycemic effect of button (Agaricus bisporus) and oyster (pleurotus ostreatus) mushrooms on streptozotocin induced diabetic mice.
  • Referans141 Kumar, P. M. R., Kumar, M. S., Manivel, A., Mohan, S. C. (2018). Structural Characterization and Anti-Diabetic Activity of Polysaccharides from Agaricus bisporus Mushroom. Phytochemistry, 12(1), 14-20.
  • Referans142 Zaid, O. A. A., Sonbaty, S. E., Neama, M. A. Anti-diabetic activity of Agaricus bisporus: A biochemical and pathological study. Zaid, Omayma AR Abou, SawsanM EL Sonbaty, and M. A. Neama. "Anti-diabetic activity of Agaricus bisporus: A biochemical and pathological study."
  • Referans143 Balakrishnan, P., Loganayagi, C. T. (2018). Antihyperglycemic activity of Agaricus bisporus mushroom extracts on alloxan induced diabetic rats. Int J Pharma Res Health Sci, 6(2), 2475-79.
  • Referans144 Kim, H. M., Kang, J. S., Kim, J. Y., Park, S. K., Kim, H. S., Lee, Y. J., Han, S. B. (2010). Evaluation of antidiabetic activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse. International immunopharmacology, 10(1), 72-78.
  • Referans145 Zhang, L., Liu, Y., Ke, Y., Liu, Y., Luo, X., Li, C., Hu, B. (2018). Antidiabetic activity of polysaccharides from Suillellus luridus in streptozotocin-induced diabetic mice. International journal of biological macromolecules, 119, 134-140.
  • Referans146 Stojkovic, D., Smiljkovic, M., Ciric, A., Glamoclija, J., Van Griensven, L., Ferreira, I. C., Sokovic, M. (2019). An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes. South African Journal of Botany, 120, 100-103.
  • Referans147 Vincent, M., Philippe, E., Everard, A., Kassis, N., Rouch, C., Denom, J., Migrenne, S. (2013). Dietary supplementation with Agaricus blazei murill extract prevents diet‐induced obesity and insulin resistance in rats. Obesity, 21(3), 553-561.
  • Referans148 Chen, L., Zhang, Y., Sha, O., Xu, W., Wang, S. (2016). Hypolipidaemic and hypoglycaemic activities of polysaccharide from Pleurotus eryngii in Kunming mice. International journal of biological macromolecules, 93, 1206-1209.
  • Referans149 Oluba, O. M., Onyeneke, E. C., Ojieh, G. C., Idonije, B.O. (2010). Evaluation of the hypoglycemic effect of aqueous extract of Ganoderma lucidum on STZ-induced diabetic wistar rats. Ann Biol Res, 1(3), 41-49.
  • Referans150 Ma, H. T., Hsieh, J. F., Chen, S. T. (2015). Anti-diabetic effects of Ganoderma lucidum. Phytochemistry, 114, 109-113.
  • Referans151 Xiao, C., Wu, Q., Zhang, J., Xie, Y., Cai, W., Tan, J. (2017). Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice. Journal of ethnopharmacology, 196, 47-57.
  • Referans152 Guo, W. L., Shi, F. F., Li, L., Xu, J. X., Chen, M., Wu, L., Zhang, Y. Y. (2019). Preparation of a novel Grifola frondosa polysaccharide-chromium (III) complex and its hypoglycemic and hypolipidemic activities in high fat diet and streptozotocin-induced diabetic mice. International journal of biological macromolecules, 131, 81-88.
  • Referans153 Kou, L., Du, M., Liu, P., Zhang, B., Zhang, Y., Yang, P., Wang, X. (2019). Anti-diabetic and anti-nephritic activities of Grifola frondosa mycelium polysaccharides in diet-streptozotocin-induced diabetic rats via modulation on oxidative stress. Applied biochemistry and biotechnology, 187(1), 310-322.
  • Referans154 Chen, Y., Liu, Y., Sarker, M. M. R., Yan, X., Yang, C., Zhao, L., Zhao, C. (2018). Structural characterization and antidiabetic potential of a novel heteropolysaccharide from Grifola frondosa via IRS1/PI3K-JNK signaling pathways. Carbohydrate polymers, 198, 452-461.
  • Referans155 Meera, K. S., Sudha, G., Rajathi, K., & Manjusha, G. V. (2011). Antidiabetic effect of aqueous extract of Hypsizygus ulmarius on Streptozotocin-Nicotiinamide induced diabetic rats. Asian Journal of Pharmaceutical & Biological Research (AJPBR), 1(2).
Toplam 155 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Eczacılık ve İlaç Bilimleri
Bölüm Derleme
Yazarlar

Ceren Öztürk 0000-0002-8019-7856

Funda Atila 0000-0003-1129-1045

Yayımlanma Tarihi 31 Mayıs 2021
Gönderilme Tarihi 11 Ağustos 2020
Kabul Tarihi 10 Şubat 2021
Yayımlandığı Sayı Yıl 2021

Kaynak Göster

APA Öztürk, C., & Atila, F. (2021). MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER. Journal of Faculty of Pharmacy of Ankara University, 45(2), 344-378. https://doi.org/10.33483/jfpau.779015
AMA Öztürk C, Atila F. MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER. Ankara Ecz. Fak. Derg. Mayıs 2021;45(2):344-378. doi:10.33483/jfpau.779015
Chicago Öztürk, Ceren, ve Funda Atila. “MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER”. Journal of Faculty of Pharmacy of Ankara University 45, sy. 2 (Mayıs 2021): 344-78. https://doi.org/10.33483/jfpau.779015.
EndNote Öztürk C, Atila F (01 Mayıs 2021) MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER. Journal of Faculty of Pharmacy of Ankara University 45 2 344–378.
IEEE C. Öztürk ve F. Atila, “MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER”, Ankara Ecz. Fak. Derg., c. 45, sy. 2, ss. 344–378, 2021, doi: 10.33483/jfpau.779015.
ISNAD Öztürk, Ceren - Atila, Funda. “MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER”. Journal of Faculty of Pharmacy of Ankara University 45/2 (Mayıs 2021), 344-378. https://doi.org/10.33483/jfpau.779015.
JAMA Öztürk C, Atila F. MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER. Ankara Ecz. Fak. Derg. 2021;45:344–378.
MLA Öztürk, Ceren ve Funda Atila. “MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER”. Journal of Faculty of Pharmacy of Ankara University, c. 45, sy. 2, 2021, ss. 344-78, doi:10.33483/jfpau.779015.
Vancouver Öztürk C, Atila F. MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER. Ankara Ecz. Fak. Derg. 2021;45(2):344-78.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.