MANTARLARIN BİYOLOJİK AKTİVİTELERİ İLE İLGİLİ İN VİTRO, İN VİVO VE KLİNİK DEĞERLENDİRMELER

Öz

Amaç: Mantarlar yüzyıllardan beri Uzakdoğu başta olmak üzere tüm dünyada gıda ve tıbbi amaçlı olarak kullanılmaktadır. Dünya genelinde kardiyovasküler hastalıklar, diyabet, kanser, obezite gibi hastalıkların hızla artması ve buna bağlı olarak tedavi ve bakım maliyetlerindeki artışlar, hem araştırıcılar hem de halk arasında alternatif tedavi yöntemlerine olan ilgiyi artmıştır.
Sonuç ve Tartışma: In vitro ve in vivo analizler ile klinik çalışmalar, başta Pleurotus spp, Lentinula edodes, Ganoderma lucidum, Grifolia frondosa gibi türler olmak üzere birçok mantar türünün yüzyıllardan beri süregelen geleneksel kullanımlarının doğruluğunu kanıtlamakta ve mantarlardan elde edilen ana biyoaktif bileşiklerin çeşitli hastalıkların önlenmesinde ve tedavisinde bir potansiyele sahip olduklarını göstermektedir. Bu derlemede mantarların, günümüzde sık rastlanan kanser, kardiyovasküler hastalıklar, diyabet gibi hastalıkların önlenmesi ve tedavisindeki potansiyellerini değerlendirmek amacıyla antitümör, antioksidan, antimikrobiyal, kolesterol düşürücü ve kan şekerini düzenleyici etkileri ile ilgili güncel in vitro, in vivo ve klinik çalışmalar derlenmiştir.

Anahtar Kelimeler

• Antidiyabetik
• antihiperlipidemik
• antimikrobiyal
• antioksidan
• antitümör
• mantar

IN VITRO, IN VIVO AND CLINICAL ASSESMENT ABOUT THE MEDICINAL CHARACTERISTICS OF MUSHROOMS

Öz

Objective: For centuries, mushrooms have been used for food and medicinal purposes all over the world, especially in the Far East. The rapid increase of diseases such as cardiovascular diseases, diabetes, cancer, obesity worldwide and and increases in the costs of treatment and care of these diseases have increased the interest in alternative treatment methods among both researchers and the public.

Result and Discussion: In vitro, in vivo and clinical studies have proven the accuracy of many centuries-old traditional uses of mushrooms, especially species such as Pleurotus spp., Lentinula edodes, Ganoderma lucidum, Grifolia frondosa. Moreover, the studies show that that the main bioactive compounds derived from mushrooms have great potential in the prevention and treatment of various diseases. In this article, current in vitro, in vivo and clinical studies related to antitumor, antioxidant, antimicrobial, cholesterol lowering and blood sugar regulating properities of mushrooms were reviewed in order to evaluate the potentials in the prevention and treatment of diseases such as cancer, cardiovascular diseases and diabetes.

Anahtar Kelimeler

• Antidiabetic
• antihyperlipidemic
• antimicrobial
• antioxidant
• antitumor
• mushroom

Kaynakça

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