ALT ÜNİTE BAZLI AŞILARIN PULMONER UYGULAMASINA GENEL BAKIŞ

Yıl 2021, , 109 - 130, 18.01.2021

Melike Ongun , Başaran Mutlu-ağardan , Fusun Acarturk

https://doi.org/10.33483/jfpau.800507

Öz

Amaç: Son yıllarda pulmoner bağışıklama parenteral aşılamaya ilişkin sorunları ortadan kaldırması, hem sistemik hem de mukozal bağışıklığı indüklemesi ile ilgi odağı olmuştur. Bu derlemede, inhale alt birim aşı çalışmaları ve gelişmeleri ele alınmıştır.

Sonuç ve Tartışma: Tüm patojen bazlı aşılara kıyasla daha güvenli olan alt birim aşılar, karmaşık yapılı patojenlerin neden olduğu hastalıklarda spesifik ve koruyucu bağışıklık yanıtı oluşturmaktadır. Bu aşıların, çeşitli taşıyıcı sistemler ve adjuvanlarla formüle edildiklerinde, solunum sisteminde hedeflenen bölgede spesifik immün yanıt oluşturduğu yapılan çalışmalarla gösterilmiştir. Son yıllarda konu ile ilgili yapılan araştırmalar stabil, invazif olmayan, soğuk zincir gerektirmeyen, kitlesel aşılamaya uygun kuru toz inhale aşıların formülasyonlarının geliştirilmesi ve bu aşılara uygun tek kullanımlık cihaz tasarımı üzerine odaklanmaktadır.

Anahtar Kelimeler

Alt birim aşı, inhale aşı, pulmoner bağışıklama

AN OVERVIEW OF SUBUNIT-BASED VACCINES FOR PULMONARY ADMINISTRATION

Öz

Objective: In recent years, pulmonary immunization has been the center of interest as it eliminates the problems related the parenteral vaccination and induces both systemic and mucosal immunity. In this review, the inhaled subunit vaccination studies and recent developments have been discussed.

Result and Discussion: Subunit vaccines, which are safer compared to whole pathogen-based vaccines, have provided a specific and protective immune response in diseases caused by complex pathogens. It has been shown that the formulations of these vaccines with carrier systems and adjuvants, obtain a specific immune response in the targeted area of the respiratory system. The recent studies focus on the formulation development of stable, non-invasive, dry powder inhaled vaccines that do not require cold chain storage and suitable for mass vaccination, also disposable devices which are suitable for this vaccines.

Anahtar Kelimeler

subunit vaccine, inhalable vaccine, pulmonary immunization

Kaynakça

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