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1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS

Yıl 2021, , 598 - 614, 27.09.2021
https://doi.org/10.33483/jfpau.885888

Öz

Objective: Development of methods for the synthesis, studies of chemical, physico-chemical and biological properties of 1,2,4-triazole derivatives, in particular compounds with heterocyclic scaffolds and complex compounds as potential biologically active substances.
Result and Discussion: In this review, 40 scientific papers reporting the properties of 1,2,4-triazole derivatives were evaluated. Each class of compounds described in the review was reported with the prospect of forming the direction for further research.Because of there is no enough studies about biological action of 1,2,4-triazole derivatives in human, it encourages further research.

Destekleyen Kurum

Zaporizhzhia state medical university

Proje Numarası

2

Teşekkür

Dear Editors, thank You for the opportunity to publish the material in the Journal of the Faculty of Pharmacy of Ankara University

Kaynakça

  • Khan, S., Imam, S., Ahmad, A., Basha, S., & Husain, A. (2018). Synthesis, molecular docking with COX 1& II enzyme, ADMET screening and in vivo anti-inflammatory activity of oxadiazole, thiadiazole and triazole analogs of felbinac. Journal Of Saudi Chemical Society, 22(4), 469-484. https://doi.org/10.1016/j.jscs.2017.05.006
  • Barbuceanu, S., Draghici, C., Barbuceanu, F., Bancescu, G., & Saramet, G. (2015). Design, Synthesis, Characterization and Antimicrobial Evaluation of Some Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolotriazole Class. Chemical And Pharmaceutical Bulletin, 63(9), 694-700. https://doi.org/10.1248/cpb.c15-00379
  • Barbuceanu, S., Draghici, C., Barbuceanu, F., Bancescu, G., & Saramet, G. (2015). Design, Synthesis, Characterization and Antimicrobial Evaluation of Some Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolotriazole Class. Chemical And Pharmaceutical Bulletin, 63(9), 694-700. https://doi.org/10.1248/cpb.c15-00379
  • Nastasă, C., Vodnar, D., Ionuţ, I., Stana, A., Benedec, D., & Tamaian, R. et al. (2018). Antibacterial Evaluation and Virtual Screening of New Thiazolyl-Triazole Schiff Bases as Potential DNA-Gyrase Inhibitors. International Journal Of Molecular Sciences, 19(1), 222. https://doi.org/10.3390/ijms19010222
  • Karbalaei, M., Seifi, M., & Sheibani, H. (2014). Regioselective ring opening of 2,2-dicyanooxiranes by 1,3-dinucleophiles in the presence of Lewis acids such as bismuth(III) nitrate pentahydrate [Bi(NO3)3·5H2O] and zirconium(IV) chloride (ZrCl4). Research On Chemical Intermediates, 41(7), 4679-4686. https://doi.org/10.1007/s11164-014-1560-6
  • S -substituted derivatives of 1,2,4-triazol-3-thiol as new drug candidates for type II diabetes. (2018), 42(3). https://doi.org/10.3906/kim-1705-17
  • LUO, J., Liu, Y., LIU, Y., WANG, J., CHAI, T., & YUAN, J. et al. (2017). Synthesis and Theoretical Studies of a New Insensitive Explosive, 2'-methyl-3-nitro-2'H-[1, 3'-bi(1,2,4-triazole)]-5, 5'-diamine. Central European Journal Of Energetic Materials, 14(2), 269-280. https://doi.org/10.22211/cejem/68913
  • Ahmed, S., Zayed, M., El-Messery, S., Al-Agamy, M., & Abdel-Rahman, H. (2016). Design, Synthesis, Antimicrobial Evaluation and Molecular Modeling Study of 1,2,4-Triazole-Based 4-Thiazolidinones. Molecules, 21(5), 568. https://doi.org/10.3390/molecules21050568
  • Ali, G., El-Hiti, G., Tomi, I., Haddad, R., Al-Qaisi, A., & Yousif, E. (2016). Photostability and Performance of Polystyrene Films Containing 1,2,4-Triazole-3-thiol Ring System Schiff Bases. Molecules, 21(12), 1699. https://doi.org/10.3390/molecules21121699.
  • Lin, G., Duan, W., Yang, L., Huang, M., & Lei, F. (2017). Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers. Molecules, 22(2), 193. https://doi.org/10.3390/molecules22020193
  • Benhammadi, S., Salimairaten, S., & Othman, A. (2016). Synthetic Studies and Antibacterial Activity of Nucleobases and their N- and S-Glucosidesfrom 2-Amino Benzoic Acid and its Benzamido Derivatives. Oriental Journal Of Chemistry, 32(5), 2567-2576. https://doi.org/10.13005/ojc/320528
  • Popiołek, Ł., Paruch, K., Patrejko, P., Biernasiuk, A., & Wujec, M. (2016). New 3-hydroxy-2-naphthoic hydrazide derivatives: thiosemicarbazides and 1,2,4-triazole-3-thiones, their synthesis and in vitro antimicrobial evaluation. Journal Of The Iranian Chemical Society, 13(10), 1945-1951. https://doi.org/10.1007/s13738-016-0911-1
  • Boraei, A., El Ashry, E., & Duerkop, A. (2016). Regioselectivity of the alkylation of S-substituted 1,2,4-triazoles with dihaloalkanes. Chemistry Central Journal, 10(1). doi: 10.1186/s13065-016-0165-0
  • Khalid, W., Badshah, A., Khan, A., Nadeem, H., & Ahmed, S. (2018). Synthesis, characterization, molecular docking evaluation, antiplatelet and anticoagulant actions of 1,2,4 triazole hydrazone and sulphonamide novel derivatives. Chemistry Central Journal, 12(1). https://doi.org/10.1186/s13065-018-0378-5
  • Sargsyan, A., Avakyan, A., Vartanyan, S., Stepanyan, G., & Paronikyan, R. (2018). Synthesis of New 1,4-Benzodioxanуl-1,2,4-triazole Derivatives. Russian Journal Of General Chemistry, 88(4), 839-842. https://doi.org/10.1134/s1070363218040345
  • Idrees, M., Kola, S., & Siddiqui, N. (2018). Synthesis of Novel Series of Quinolino[3,2-f][1,2,4]triazolo[3,4-b][1,3,4]-thiadiazepines Derivatives Incorporated with 3-[5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl] Moiety as Potent Antimicrobial Agent. Asian Journal Of Chemistry, 30(9), 2129-2133. https://doi.org/10.14233/ajchem.2018.21483
  • Kumar, A., Naaz, A., Prakasham, A., Gangwar, M., Butcher, R., Panda, D., & Ghosh, P. (2017). Potent Anticancer Activity with High Selectivity of a Chiral Palladium N-Heterocyclic Carbene Complex. ACS Omega, 2(8), 4632-4646. https://doi.org/10.1021/acsomega.7b00688
  • Li, J., Liu, H., Guo, Z., Yang, M., Song, J., & Ma, H. (2018). Two Cu(ii)-triadimenol complexes as potential fungicides: synergistic actions and DFT calculations. RSC Advances, 8(6), 2933-2940. https://doi.org/10.1039/c7ra10572j
  • van Dijk, B., Hofmann, J., & Hetterscheid, D. (2018). Pinpointing the active species of the Cu(DAT) catalyzed oxygen reduction reaction. Physical Chemistry Chemical Physics, 20(29), 19625-19634. https://doi.org/10.1039/c8cp03419b
  • Wang, X., Bai, X., Lin, H., Sun, J., Wang, X., & Liu, G. (2018). A series of new polyoxometalate-based metal–organic complexes with different rigid pyridyl-bis(triazole) ligands: assembly, structures and electrochemical properties. RSC Advances, 8(40), 22676-22686. https://doi.org/10.1039/c8ra03277g
  • Popov, I., Davis, B., Mukundan, R., Batista, E., & Yang, P. (2019). Catalyst-Inspired Charge Carriers for High Energy Density Redox Flow Batteries. Frontiers In Physics, 6. https://doi.org/10.3389/fphy.2018.00141
  • Arkhipushkin, I., Shikhaliev, K., Potapov, A., Sapronova, L., & Kazansky, L. (2017). Inhibition of Brass (80/20) by 5-Mercaptopentyl-3-Amino-1,2,4-Triazole in Neutral Solutions. Metals, 7(11), 488. https://doi.org/10.3390/met7110488
  • Del Bene, J., Elguero, J., & Alkorta, I. (2018). Complexes of CO2 with the Azoles: Tetrel Bonds, Hydrogen Bonds and Other Secondary Interactions. Molecules, 23(4), 906. https://doi.org/10.3390/molecules23040906
  • Bagihalli, G., Patil, S., & Badami, P. (2009). Synthesis, spectral characterization, in vitro microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases. Journal Of Enzyme Inhibition And Medicinal Chemistry, 24(3), 730-741. https://doi.org/10.1080/14756360802361571
  • Chen, D., Zheng, Y., Shi, D., & Fang, S. (2020). An acid-base resistant polyoxometalate-based metal–organic framework constructed from {Cu4Cl}7+ and {Cu2(CO2)4} clusters for photocatalytic degradation of organic dye. Journal Of Solid State Chemistry, 287, 121384. https://doi.org/10.1016/j.jssc.2020.121384
  • Hulina, Y., & Kaplaushenko, A. (2017). Synthesis and physical-chemical properties of 6-(5-(1Н-tetrazole-1-ylmethyl)-4-R-1,2,4-triazole-3-ylthio)pyridin-3-amines and 6-((5-(1Н-tetrazole-1-yl)methil-4-R-1,2,4-triazole-3-ylthio)pyridin-3-yl)-(alk,ar,heter)ylmethanimines. Zaporozhye Medical Journal, 0(1). https://doi.org/10.14739/2310-1210.2017.1.91726
  • Frolova, Y. (2020). Design, synthesis, antimicrobial and antifungal activities of new 1,2,4-triazole derivatives containing 1H-tetrazole moiety. Ankara Universitesi Eczacilik Fakultesi Dergisi, 70-88. https://doi.org/10.33483/jfpau.574001
  • Shcherbyna, R. (2019). microwave-assisted synthesis of some new derivatives of 4-substituted-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles. Ankara Universitesi Eczacilik Fakultesi Dergisi, 220-229. doi: 10.33483/jfpau.533166
  • Shcherbyna, R., Parchenko, V., Varynskyi, B., & Kaplaushenko, A. (2019). The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio) acetate substance. Current Issues In Pharmacy And Medical Sciences, 32(1), 5-9. doi: 10.2478/cipms-2019-0001
  • Varynskyi, B., & Kaplaushenko, A. (2019). The Force Degradation Study of The Morpholinium 2-((4-(2-Methoxyphenyl)-5-(Pyridin-4-YL)-4H-1,2,4-Triazol-3-YL) Thio) Acetate. Indonesian Journal Of Pharmacy, 30(1), 25. doi: 10.14499/indonesianjpharm30iss1pp25
  • Danilchenko, D., & Safonov, А. (2017). Diuretic activity of 2-((4-amino-5-R-4H-1,2,4-triazole-3-yl)thio)acetohydrazides. Zaporozhye Medical Journal, 0(4). doi: 10.14739/2310-1210.2017.4.105283

TIP VE ECZACILIK ALANINDAKİ 1,2,4-TRİAZOL TÜREVLERİ VE UYGULAMA ÖNERİLERİ

Yıl 2021, , 598 - 614, 27.09.2021
https://doi.org/10.33483/jfpau.885888

Öz

Amaç: 1,2,4-triazol türevlerinin,özellikle heterosiklik iskelete sahip ve biyolojik olarak aktif bileşiklerin, sentezi, kimyasal, fizikokimyasal ve biyolojik özelliklerinin incelenmesi için yöntemlerin geliştirilmesi.
Sonuç ve Tartışma: Bu derlemede, 1,2,4-triazol türevlerinin özelliklerinin bildirildiği 40 bilimsel makale değerlendirilmiştir. Verilenher bileşik sınıfı gelecekteki çalışmalara yön verecek şekilde bildirilmiştir.1,2,4-triazol türevlerinin insandaki biyolojik etkileri hakkında yeterli çalışma olmaması, bu alanda daha fazla çalışma yapılmasını teşvik etmektedir.

Proje Numarası

2

Kaynakça

  • Khan, S., Imam, S., Ahmad, A., Basha, S., & Husain, A. (2018). Synthesis, molecular docking with COX 1& II enzyme, ADMET screening and in vivo anti-inflammatory activity of oxadiazole, thiadiazole and triazole analogs of felbinac. Journal Of Saudi Chemical Society, 22(4), 469-484. https://doi.org/10.1016/j.jscs.2017.05.006
  • Barbuceanu, S., Draghici, C., Barbuceanu, F., Bancescu, G., & Saramet, G. (2015). Design, Synthesis, Characterization and Antimicrobial Evaluation of Some Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolotriazole Class. Chemical And Pharmaceutical Bulletin, 63(9), 694-700. https://doi.org/10.1248/cpb.c15-00379
  • Barbuceanu, S., Draghici, C., Barbuceanu, F., Bancescu, G., & Saramet, G. (2015). Design, Synthesis, Characterization and Antimicrobial Evaluation of Some Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolotriazole Class. Chemical And Pharmaceutical Bulletin, 63(9), 694-700. https://doi.org/10.1248/cpb.c15-00379
  • Nastasă, C., Vodnar, D., Ionuţ, I., Stana, A., Benedec, D., & Tamaian, R. et al. (2018). Antibacterial Evaluation and Virtual Screening of New Thiazolyl-Triazole Schiff Bases as Potential DNA-Gyrase Inhibitors. International Journal Of Molecular Sciences, 19(1), 222. https://doi.org/10.3390/ijms19010222
  • Karbalaei, M., Seifi, M., & Sheibani, H. (2014). Regioselective ring opening of 2,2-dicyanooxiranes by 1,3-dinucleophiles in the presence of Lewis acids such as bismuth(III) nitrate pentahydrate [Bi(NO3)3·5H2O] and zirconium(IV) chloride (ZrCl4). Research On Chemical Intermediates, 41(7), 4679-4686. https://doi.org/10.1007/s11164-014-1560-6
  • S -substituted derivatives of 1,2,4-triazol-3-thiol as new drug candidates for type II diabetes. (2018), 42(3). https://doi.org/10.3906/kim-1705-17
  • LUO, J., Liu, Y., LIU, Y., WANG, J., CHAI, T., & YUAN, J. et al. (2017). Synthesis and Theoretical Studies of a New Insensitive Explosive, 2'-methyl-3-nitro-2'H-[1, 3'-bi(1,2,4-triazole)]-5, 5'-diamine. Central European Journal Of Energetic Materials, 14(2), 269-280. https://doi.org/10.22211/cejem/68913
  • Ahmed, S., Zayed, M., El-Messery, S., Al-Agamy, M., & Abdel-Rahman, H. (2016). Design, Synthesis, Antimicrobial Evaluation and Molecular Modeling Study of 1,2,4-Triazole-Based 4-Thiazolidinones. Molecules, 21(5), 568. https://doi.org/10.3390/molecules21050568
  • Ali, G., El-Hiti, G., Tomi, I., Haddad, R., Al-Qaisi, A., & Yousif, E. (2016). Photostability and Performance of Polystyrene Films Containing 1,2,4-Triazole-3-thiol Ring System Schiff Bases. Molecules, 21(12), 1699. https://doi.org/10.3390/molecules21121699.
  • Lin, G., Duan, W., Yang, L., Huang, M., & Lei, F. (2017). Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers. Molecules, 22(2), 193. https://doi.org/10.3390/molecules22020193
  • Benhammadi, S., Salimairaten, S., & Othman, A. (2016). Synthetic Studies and Antibacterial Activity of Nucleobases and their N- and S-Glucosidesfrom 2-Amino Benzoic Acid and its Benzamido Derivatives. Oriental Journal Of Chemistry, 32(5), 2567-2576. https://doi.org/10.13005/ojc/320528
  • Popiołek, Ł., Paruch, K., Patrejko, P., Biernasiuk, A., & Wujec, M. (2016). New 3-hydroxy-2-naphthoic hydrazide derivatives: thiosemicarbazides and 1,2,4-triazole-3-thiones, their synthesis and in vitro antimicrobial evaluation. Journal Of The Iranian Chemical Society, 13(10), 1945-1951. https://doi.org/10.1007/s13738-016-0911-1
  • Boraei, A., El Ashry, E., & Duerkop, A. (2016). Regioselectivity of the alkylation of S-substituted 1,2,4-triazoles with dihaloalkanes. Chemistry Central Journal, 10(1). doi: 10.1186/s13065-016-0165-0
  • Khalid, W., Badshah, A., Khan, A., Nadeem, H., & Ahmed, S. (2018). Synthesis, characterization, molecular docking evaluation, antiplatelet and anticoagulant actions of 1,2,4 triazole hydrazone and sulphonamide novel derivatives. Chemistry Central Journal, 12(1). https://doi.org/10.1186/s13065-018-0378-5
  • Sargsyan, A., Avakyan, A., Vartanyan, S., Stepanyan, G., & Paronikyan, R. (2018). Synthesis of New 1,4-Benzodioxanуl-1,2,4-triazole Derivatives. Russian Journal Of General Chemistry, 88(4), 839-842. https://doi.org/10.1134/s1070363218040345
  • Idrees, M., Kola, S., & Siddiqui, N. (2018). Synthesis of Novel Series of Quinolino[3,2-f][1,2,4]triazolo[3,4-b][1,3,4]-thiadiazepines Derivatives Incorporated with 3-[5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl] Moiety as Potent Antimicrobial Agent. Asian Journal Of Chemistry, 30(9), 2129-2133. https://doi.org/10.14233/ajchem.2018.21483
  • Kumar, A., Naaz, A., Prakasham, A., Gangwar, M., Butcher, R., Panda, D., & Ghosh, P. (2017). Potent Anticancer Activity with High Selectivity of a Chiral Palladium N-Heterocyclic Carbene Complex. ACS Omega, 2(8), 4632-4646. https://doi.org/10.1021/acsomega.7b00688
  • Li, J., Liu, H., Guo, Z., Yang, M., Song, J., & Ma, H. (2018). Two Cu(ii)-triadimenol complexes as potential fungicides: synergistic actions and DFT calculations. RSC Advances, 8(6), 2933-2940. https://doi.org/10.1039/c7ra10572j
  • van Dijk, B., Hofmann, J., & Hetterscheid, D. (2018). Pinpointing the active species of the Cu(DAT) catalyzed oxygen reduction reaction. Physical Chemistry Chemical Physics, 20(29), 19625-19634. https://doi.org/10.1039/c8cp03419b
  • Wang, X., Bai, X., Lin, H., Sun, J., Wang, X., & Liu, G. (2018). A series of new polyoxometalate-based metal–organic complexes with different rigid pyridyl-bis(triazole) ligands: assembly, structures and electrochemical properties. RSC Advances, 8(40), 22676-22686. https://doi.org/10.1039/c8ra03277g
  • Popov, I., Davis, B., Mukundan, R., Batista, E., & Yang, P. (2019). Catalyst-Inspired Charge Carriers for High Energy Density Redox Flow Batteries. Frontiers In Physics, 6. https://doi.org/10.3389/fphy.2018.00141
  • Arkhipushkin, I., Shikhaliev, K., Potapov, A., Sapronova, L., & Kazansky, L. (2017). Inhibition of Brass (80/20) by 5-Mercaptopentyl-3-Amino-1,2,4-Triazole in Neutral Solutions. Metals, 7(11), 488. https://doi.org/10.3390/met7110488
  • Del Bene, J., Elguero, J., & Alkorta, I. (2018). Complexes of CO2 with the Azoles: Tetrel Bonds, Hydrogen Bonds and Other Secondary Interactions. Molecules, 23(4), 906. https://doi.org/10.3390/molecules23040906
  • Bagihalli, G., Patil, S., & Badami, P. (2009). Synthesis, spectral characterization, in vitro microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases. Journal Of Enzyme Inhibition And Medicinal Chemistry, 24(3), 730-741. https://doi.org/10.1080/14756360802361571
  • Chen, D., Zheng, Y., Shi, D., & Fang, S. (2020). An acid-base resistant polyoxometalate-based metal–organic framework constructed from {Cu4Cl}7+ and {Cu2(CO2)4} clusters for photocatalytic degradation of organic dye. Journal Of Solid State Chemistry, 287, 121384. https://doi.org/10.1016/j.jssc.2020.121384
  • Hulina, Y., & Kaplaushenko, A. (2017). Synthesis and physical-chemical properties of 6-(5-(1Н-tetrazole-1-ylmethyl)-4-R-1,2,4-triazole-3-ylthio)pyridin-3-amines and 6-((5-(1Н-tetrazole-1-yl)methil-4-R-1,2,4-triazole-3-ylthio)pyridin-3-yl)-(alk,ar,heter)ylmethanimines. Zaporozhye Medical Journal, 0(1). https://doi.org/10.14739/2310-1210.2017.1.91726
  • Frolova, Y. (2020). Design, synthesis, antimicrobial and antifungal activities of new 1,2,4-triazole derivatives containing 1H-tetrazole moiety. Ankara Universitesi Eczacilik Fakultesi Dergisi, 70-88. https://doi.org/10.33483/jfpau.574001
  • Shcherbyna, R. (2019). microwave-assisted synthesis of some new derivatives of 4-substituted-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles. Ankara Universitesi Eczacilik Fakultesi Dergisi, 220-229. doi: 10.33483/jfpau.533166
  • Shcherbyna, R., Parchenko, V., Varynskyi, B., & Kaplaushenko, A. (2019). The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio) acetate substance. Current Issues In Pharmacy And Medical Sciences, 32(1), 5-9. doi: 10.2478/cipms-2019-0001
  • Varynskyi, B., & Kaplaushenko, A. (2019). The Force Degradation Study of The Morpholinium 2-((4-(2-Methoxyphenyl)-5-(Pyridin-4-YL)-4H-1,2,4-Triazol-3-YL) Thio) Acetate. Indonesian Journal Of Pharmacy, 30(1), 25. doi: 10.14499/indonesianjpharm30iss1pp25
  • Danilchenko, D., & Safonov, А. (2017). Diuretic activity of 2-((4-amino-5-R-4H-1,2,4-triazole-3-yl)thio)acetohydrazides. Zaporozhye Medical Journal, 0(4). doi: 10.14739/2310-1210.2017.4.105283
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Derleme
Yazarlar

Yurii Sameliuk 0000-0001-8675-5081

Tetyana Kaplaushenko 0000-0001-5092-3370

Fadi Al Zedan 0000-0001-9596-2779

Proje Numarası 2
Yayımlanma Tarihi 27 Eylül 2021
Gönderilme Tarihi 24 Şubat 2021
Kabul Tarihi 18 Mayıs 2021
Yayımlandığı Sayı Yıl 2021

Kaynak Göster

APA Sameliuk, Y., Kaplaushenko, T., & Al Zedan, F. (2021). 1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS. Journal of Faculty of Pharmacy of Ankara University, 45(3), 598-614. https://doi.org/10.33483/jfpau.885888
AMA Sameliuk Y, Kaplaushenko T, Al Zedan F. 1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS. Ankara Ecz. Fak. Derg. Eylül 2021;45(3):598-614. doi:10.33483/jfpau.885888
Chicago Sameliuk, Yurii, Tetyana Kaplaushenko, ve Fadi Al Zedan. “1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS”. Journal of Faculty of Pharmacy of Ankara University 45, sy. 3 (Eylül 2021): 598-614. https://doi.org/10.33483/jfpau.885888.
EndNote Sameliuk Y, Kaplaushenko T, Al Zedan F (01 Eylül 2021) 1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS. Journal of Faculty of Pharmacy of Ankara University 45 3 598–614.
IEEE Y. Sameliuk, T. Kaplaushenko, ve F. Al Zedan, “1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS”, Ankara Ecz. Fak. Derg., c. 45, sy. 3, ss. 598–614, 2021, doi: 10.33483/jfpau.885888.
ISNAD Sameliuk, Yurii vd. “1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS”. Journal of Faculty of Pharmacy of Ankara University 45/3 (Eylül 2021), 598-614. https://doi.org/10.33483/jfpau.885888.
JAMA Sameliuk Y, Kaplaushenko T, Al Zedan F. 1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS. Ankara Ecz. Fak. Derg. 2021;45:598–614.
MLA Sameliuk, Yurii vd. “1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS”. Journal of Faculty of Pharmacy of Ankara University, c. 45, sy. 3, 2021, ss. 598-14, doi:10.33483/jfpau.885888.
Vancouver Sameliuk Y, Kaplaushenko T, Al Zedan F. 1,2,4-TRIAZOLE DERIVATIVES IN MEDICINE AND PHARMACY AND APPLICATION PROSPECTS. Ankara Ecz. Fak. Derg. 2021;45(3):598-614.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.