BAZI 1,2,4-TRİAZOL YOĞUNLAŞTIRILMIŞ TÜREVLERİNİN SENTEZİ, ÖZELLİKLERI VE BİYOLOJİK POTANSİYELİ

Öz

Amaç: Çalışmanın amacı 1,2,4-triazol, indol ve pirol içeren biyolojik olarak aktif heterosiklik sistemlerin sentezi için etkili yöntemler geliştirmektir. Bu çalısmada, öncelikle çalısma için gerekli olan on üç adet [1,2,4]triazolo[3,4-b][1,3,4]tiadiazol bilesigi sentezlenmistir.

Gereç ve Yönetim: Sentezlenen bileşiklerin kimyasal yapıları elementel analiz, 1H NMR, LC-MS teknikleri ile karakterize edildi. Sentezlenen maddelerin biyolojik potansiyelleri, moleküler yerleştirme yöntemi ile tahmin edildi.

Sonuç ve Tartışma: [1,2,4]triazolo[3,4-b][1,3,4]tiadiazollerin sentezi için optimal bir yöntem geliştirildi. Moleküler modelleme çalışmalarında, bileşiklerin bazı açılardan bilinen ilaçlara benzer olduğu bulunmuştur. Ayrıca her bir molekülün siklooksijenaz-1, lanosterol 14-α-demetilaz ve anaplastik lenfoma kinazların kristal yapılarındaki aktif bölgeler ile etkileşimi in siliko olarak değerlendirildi.

Anahtar Kelimeler

• İndol
• moleküler modelleme
• pirol
• sentez
• 1-2-4-triazol

SYNTHESIS, PROPERTIES AND BIOLOGICAL POTENTIAL SOME CONDENSED DERIVATIVES 1,2,4-TRIAZOLE

Öz

Objective: The aim of the work was to develop effective methods for the synthesis of biologically active heterocyclic systems containing pyrrole, indole and 1,2,4-triazole. In this study, firstly fourteen [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles compounds requiring for this study were synthesized.

Material and Method: Chemical structures of synthesized compounds were characterized with elemental analysis, 1H NMR, LC-MS techniques. The biological potential of the synthesized substances was estimated by the molecular docking method.

Result and Discussion: An optimal method for the synthesis of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles has been developed. In molecular modeling studies, the compounds were found to be similar to known drugs in some respects. Besides, the interaction of each molecule in the active site of the crystal structures of cyclooxygenase-1, lanosterol 14-α-demethylase, kinases of anaplastic lymphoma were considered as in silico.

Anahtar Kelimeler

• Docking
• indole
• pyrrole
• synthesis
• 1-2-4-triazole

Kaynakça

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