MYRTUS COMMUNIS L.’İN ANTİMİKROBİYAL VE SİTOTOKSİK AKTİVİTELERİ

Yıl 2008, Cilt: 37 Sayı: 3, 191 - 199, 01.09.2008

Tuba Mert Tuğçe Fafal Bijen Kıvçak Tansel Öztürk H.

https://doi.org/10.1501/Eczfak_0000000501

Cited By: 2

Öz

Bu çalışmada, Myrtus communis L.’nin n-hekzan, metanol, etanol, etil asetat ve su ekstrelerinin, antimikrobiyal ve sitotoksik aktiviteleri değerlendirildi. Ekstrelerin antimikrobiyal aktiviteleri, bakteri olarak Escherichia coli ATCC 29998, Escherichia coli ATCC 25922, Escherichia coli ATCC 11230, Staphylococcus aureus ATCC6538P , Staphylococcus aureus ATCC 29213, Staphylococcus epidermidis ATCC 12228, Salmonella typhimurium CCM 5445, Enterobacter cloacae ATCC 13047, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853 ve mantar olarakCandida albicans ATCC 10239 ’ a karşı disk difüzyon metodu ile tayin edildi. Ekstrelerin tümü, Escherichia coli ATCC 29998, Escherichia coli ATCC 11230, Staphylococcus epidermidis ATCC 12228, Salmonella typhimurium CCM 5445 ve Pseudomonas aeruginosa ATCC 27853 üzerinde etkili olmuştur. Escherichia coli ATCC 25922 üzerinde ise sadece metanol ekstresi etki göstermiştir. Enterobacter cloacae ATCC 13047, Enterococcus faecalis ATCC 29212 ve Candida albicans üzerinde ise hiçbir ekstre etkili olmamıştır. Ekstrelerin sitotoksik aktiviteleri Brine shrimp yöntemiyle değerlendirildi. Ekstrelerin hepsi Brine shrimp’e karşı sitotoksik aktivite gösterdi

Anahtar Kelimeler

Myrtus communis L., Myrtaceae, Sitotoksik aktivite, Antimikrobiyal aktivite

ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF MYRTUS COMMUNIS L

Öz

The antimicrobial and cytotoxic activities of n-hexane, methanol, ethanol, ethyl acetate and water extracts of Myrtus communis L. leaves were evaluated in this study. The antimicrobial activities of the extracts were reported against Escherichia coli ATCC 29998, Escherichia coli ATCC 25922, Escherichia coli ATCC 11230, Staphylococcus aureus ATCC 6538P , Staphylococcus aureus ATCC 29213, Staphylococcus epidermidis ATCC 12228, Salmonella typhimurium CCM 5445, Enterobacter cloacae ATCC 13047, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853 as bacteria and Candida albicans ATCC 10239 as yeastlike fungi by disc diffusion method. All of the extracts inhibited the growth of Escherichia coli ATCC 29998, Escherichia coli ATCC 11230, Staphylococcus epidermidis ATCC 12228, Salmonella typhimurium CCM 5445 and Pseudomonas aeruginosa ATCC 27853. The growth of Escherichia coli ATCC 25922 was only inhibited by the methanol extract. None of the tested extracts showed activity against Enterobacter cloacae ATCC 13047, Enterococcus faecalis ATCC 29212 and Candida albicans. Cytotoxic activity of the extracts was tested in vitro against Brine shrimp. Cytotoxicity was evaluated by brine shrimp lethality bioassay. All of the extracts showed cytotoxic activity against brine shrimp

Anahtar Kelimeler

Myrtus communis L., Myrtaceae, Cytotoxic activity, Antimicrobial activity