BibTex RIS Kaynak Göster

ETİL {5-[(2-(4-KLOROBENZİLSULFANİL)-4-KLOROTİYAZOL-5- İL)METİLEN]-2,4-DİOKSO-TİYAZOLİDİN–3-İL} ASETAT BİLEŞİĞİNİN SENTEZİ VE ALDOZ REDÜKTAZ İNHİBİTÖR ETKİSİ : SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY

Yıl 2006, Cilt: 35 Sayı: 4, 245 - 254, 01.12.2006

Oya Bozdağ Dündar

https://doi.org/10.1501/Eczfak_0000000067

Öz

Bu çalışmada, etil {5-[(2-(4-klorobenzilsulfanil)-4-klorotiyazol-5-il)metilen]-2,4-dioksotiyazolidin–3-il}asetat bileşiği sentez edilmiş ve yapısı IR, 1H-NMR, mass and elementel analiz bulguları ile aydınlatılmıştır. Sentez edilen bileşiğin, in-vitro ortamda spektrofotometrik olarak sıçan böbrek AR’ını inhibe etme gücü test edilmiştir. Sentez edilen bileşik % 6.51±0.97 inhibitor aktivite göstermiştir

Anahtar Kelimeler

Tiyazolidin-2 4-dionlar tiyazol türevleri aldoz redüktaz inhibitör etki

SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE

Yıl 2006, Cilt: 35 Sayı: 4, 245 - 254, 01.12.2006

Oya Bozdağ Dündar

https://doi.org/10.1501/Eczfak_0000000067

Öz

In this study, ethyl {5-[(2-(4-chlorobenzylsulphanyl)-4-chlorothiazole-5-yl)methylene]-2,4-dioxothiazolidine–3-yl}acetate compound was synthesized and its structure has been elucidated by IR, 1H-NMR, mass spectra and elementary analysis. The synthesized compound was tested for its ability to inhibit rat kidney AR by an in-vitro spectrophotometric assay. Synthesized compound showed inhibitory activity, 6.51±0.97 %

Anahtar Kelimeler

Thiazolidine-2 4-diones thiazole derivatives aldose reductase inhibitory effect

Toplam 0 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA75SC97AP
Bölüm Araştırma Makalesi
Yazarlar

Oya Bozdağ Dündar Bu kişi benim

Yayımlanma Tarihi 1 Aralık 2006
Gönderilme Tarihi 1 Aralık 2006
Yayımlandığı Sayı Yıl 2006 Cilt: 35 Sayı: 4

Kaynak Göster

APA Bozdağ Dündar, O. (2006). SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE. Journal of Faculty of Pharmacy of Ankara University, 35(4), 245-254. https://doi.org/10.1501/Eczfak_0000000067
AMA Bozdağ Dündar O. SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE. Ankara Ecz. Fak. Derg. Aralık 2006;35(4):245-254. doi:10.1501/Eczfak_0000000067
Chicago Bozdağ Dündar, Oya. “SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE”. Journal of Faculty of Pharmacy of Ankara University 35, sy. 4 (Aralık 2006): 245-54. https://doi.org/10.1501/Eczfak_0000000067.
EndNote Bozdağ Dündar O (01 Aralık 2006) SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE. Journal of Faculty of Pharmacy of Ankara University 35 4 245–254.
IEEE O. Bozdağ Dündar, “SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE”, Ankara Ecz. Fak. Derg., c. 35, sy. 4, ss. 245–254, 2006, doi: 10.1501/Eczfak_0000000067.
ISNAD Bozdağ Dündar, Oya. “SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE”. Journal of Faculty of Pharmacy of Ankara University 35/4 (Aralık 2006), 245-254. https://doi.org/10.1501/Eczfak_0000000067.
JAMA Bozdağ Dündar O. SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE. Ankara Ecz. Fak. Derg. 2006;35:245–254.
MLA Bozdağ Dündar, Oya. “SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE”. Journal of Faculty of Pharmacy of Ankara University, c. 35, sy. 4, 2006, ss. 245-54, doi:10.1501/Eczfak_0000000067.
Vancouver Bozdağ Dündar O. SYNTHESIS AND ALDOSE REDUCTASE INHIBITORY EFFECT OF ETHYL {5-[(2- (4-CHLORO-BENZYLSULPHANYL)- 4-CHLORO-THİAZOLE-5-YL)METHYLENE]- 2,4-DIOXO-THİAZOLİDİNE–3-YL}ACETATE. Ankara Ecz. Fak. Derg. 2006;35(4):245-54.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.