SAF VE DOZAJ FORMLARINDA METOPROLOL TARTARATIN SPEKTROFOTOMETRİK TAYİNİ

Yıl 2018, Cilt: 42 Sayı: 1, 33 - 42, 31.01.2018

Anastasiia Donchenko Svitlana Vasyuk

Öz

Amaç: Metoprolol tartaratın belirlenmesi için saf ve farmasötik ilaçlarında yeni spektrofotometrik bir
yöntem geliştirildi.

Gereç ve Yöntem: Bu yöntem 493 nm’de maksimum emilim ile boyalı reaksiyon ürünün oluşturulması
için dimetilformamid (DMF) ortamında metoprolol tartarat ile 2,3-dikloro-1,4-naftokinon arasında olan
reaksiyona dayanmaktadır. Reaksiyonun yapılması için reaktif konsantrasyonu, sıcaklık ve ısıtma süresi gibioptimal koşullar dikkatli bir şekilde incelendi ve optimize edildi. Beer kanunu 18.00-28.00 mg/100 ml
konsantrasyon aralığında gerçekleştirildi. Önerilen yöntem Ukrayna Devlet Farmakopesi onaylama taleplerine
göre geçerlidir.

Sonuç ve Tartışma: Çalışma sonuçları, işlemin ilaç formları için kalite kontrol laboratuvarlarında
uygulama açısından doğru, basit ve güncel olduğunu göstermektedir

Anahtar Kelimeler

2, 3-dikloro-1, 4-naftokinon, metaprolol tartarat, spektrofotometri, validasyon çalışmaları

SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS

Öz

Objective: A new spectrophotometric method has been developed for the determination of metoprolol
tartrate in pure and dosage forms.

Material and Method: This method is based on the reaction between metoprolol tartrate and 2,3-
dichloro-1,4-naphthoquinone in dimethylformamide (DMF) medium to form the colored reaction product with
maximum absorption at 493 nm. Optimum conditions to carry out the reaction such as concentration of reagent,
temperature and heating time were carefully studied and optimized. Beer’s law was performed at the
concentration range of 18.00-28.00 mg/100 ml. The proposed method is valid according to the validation
requirements of the State Pharmacopoeia of Ukraine.

Result and Discussion: The results of the study show that the procedure is accurate, simple and relevant
for application at the quality control laboratories for dosage forms

Anahtar Kelimeler

2, 3-dichloro-1, 4-naphthoquinone, metoprolol tartrate, spectrophotometry, validation studies

Kaynakça

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