MEME KANSERİNDE ETKİLİ TIBBİ BİTKİLER VE SEKONDER METABOLİTLERİ

Yıl 2018, Cilt: 42 Sayı: 2, 42 - 62, 31.05.2018

Serdar Özgüç Hüsniye Kayalar Ulvi Zeybek

Öz

Amaç: Bu derlemede kanıta dayalı bir yaklaşımla meme kanseri tedavisinde destekleyici olabilecek bazı tıbbi bitkilere yer verilmesi amaçlanmıştır.

Gereç ve Yöntem: Meme kanseri tedavisinde araştırmalara konu olan tıbbi bitkilerin kapsamlı olarak literatürünün derlenmesi amacıyla sağlık bilimleri alanındaki veritabanlarından yararlanılmıştır. Medline veritabanı ve Scopus ile Web of Science gibi temel atıf indekslerinde daha önce yayınlanmış makaleler için elektronik arama yapılmıştır.

Sonuç ve Tartışma: Meme kanserinde kullanılan ilaçların belli bir kısmı bitkilerden elde edilmektedir. Bazı bitkiler detoks mekanizması ile vücudu maligniteden koruyabilir. Biyolojik yanıtı modifiye eden tıbbi bitkiler kanser gelişimini de hormon ve enzim aktivitelerini modifiye ederek engelleyebilirler. Bazı bitkiler de kemoterapi ve radyoterapinin yan etkilerini azaltarak tedaviye destek olabilirler. Bu derlemede meme kanserinde potansiyel etkileri olabilecek 14 tıbbi bitkinin yanı sıra meyve ve sebze olarak tüketilen bazı kaynaklara da yer verimiştir. Türkiye florası çok zengin floraya ve endemik tıbbi bitkilere sahip olmasına rağmen, kanser araştırmaları ve bunlar arasında meme kanseri üzerine yeterli sayıda klinik çalışmanın bulunmayışı floramızın tıbbi araştırmalarda yeterince değerlendirilmediğini göstermektedir.

Anahtar Kelimeler

epilobium, meme kanseri, Morinda citrifolia, sistemik hastalık, Viscum album

MEDICINAL PLANTS AND THEIR SECONDARY METABOLITES EFFECTIVE AGAINST BREAST CANCER

Öz

Objective: This study aims at reviewing an evidence-based approach to medicinal plants for the supportive treatment of breast cancer.

Material and Method: The subject databases for health sciences are considered for comprehensive search of the literature in terms of medicinal plants for the treatment of breast cancer. An electronic search for previously published articles was conducted in Medline citations and key citation indexes such as Scopus and Web of Science.

Result and Discussion: A certain part of the medicines used in breast cancer are derived from plants. Some plants can protect the body from malignancy with their detoxification mechanism. Some medicinal plants that modify the biological response can prevent cancer development by modifying activities of hormones and enzymes. Some plants can support the treatment by reducing the side effects of chemotherapy and radiotherapy. In this review, in addition to 14 medicinal plants some sources consumed as fruits and vegetables. that may have potential effects on breast cancer are discussed. Although Turkey is one of the richest countries in terms of large flora and endemic medicinal plants, sufficient number of cancer research and clinical trials on breast cancer are not considered enough.

Anahtar Kelimeler

Breast cancer, Epilobium, Morinda citrifolia, Systemic Diseases, Viscum album

Kaynakça

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