ANTİKANSER AKTİVİTE ARAŞTIRMALARINDA ARTEMISIA ANNUA L. BİTKİSİNİN ÖNEMİ

Yıl 2017, Cilt: 41 Sayı: 3, 1 - 8, 01.09.2017

Erkan Yalcinkaya

Öz

Amaç: Kanserin dünya çapında ölüm nedenlerinin başında geldiği bilinmektedir. Normal hücre üzerine toksisite göstermeyen, sadece kanser hücresini selektif olarak yok eden ya da gelişimini durduran ilaçları geliştirmek zordur. Daha aktif, daha selektif ve daha az toksik antikanser ilaçlarını geliştirmek kanser araştırmalarının temel hedefleri olmuştur. Artemisia annua L., Geleneksel Çin Tıbbı’nda kullanılan bir tıbbi bitkidir. Bitki, plazmodyum için yoğun olarak araştırılmış ve bu alandaki kullanımı dünya geneline yayılmıştır. Bitkinin aktif bileşenlerinden olan artemisinin, antiviral, antienflamatuar, antiparaziter, antiallerjik, antifibrotik, antiaritmik, immunmodulatör, antitümör ve sitotoksik etkilidir. Bu çalışmanın amacı A. annua bitkisinin aktif maddelerinin ve kanser üzerindeki etkilerinin derlenmesidir.

Anahtar Kelimeler

antikanser aktivite, Artemisia annua L., artemisinin, kanser

THE IMPORTANCE OF ARTEMISIA ANNUA L. IN THE ANTICANCER ACTIVITY RESEARCH

Öz

Objective: Cancer is known as one of the main cause of death worldwide. It is difficult to discover novel agents that selectively kill tumor cells or inhibit their proliferation without general toxicity. Searching for more active, more selective and less toxic compounds are the main targets of cancer researches. Artemisia annua L. has been used for a long time as a medicinal plant in Traditional Chinese Medicine (TCM). Artemisinin, which is one of the active compounds of this plant. It has antiviral, antiinflammatory, antiparasitic, antiallergic, antifibrotic, antiarrhythmic, immunmodulator, antitumorigenic, cytotoxic properties. The aim of this study is to review the A. annua compounds and s

earch for their effects against various cancer cell lines.

Anahtar Kelimeler

anticancer activity, Artemisia annua L., artemisinin, cancer

Kaynakça

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