OKSİDATİF STRES VE PARKİNSON HASTALIĞI

Yıl 2019, Cilt: 43 Sayı: 1, 94 - 116, 31.01.2019

Selma Nergis Aslan Bensu Karahalil

Öz

            Amaç: Parkinson Hastalığı (PH) beyinde dopaminerjik
nöronların kaybıyla ilişkili kronik ve progresif nörodejeneratif bir
hastalıktır. Yaşlılık tüm nörodejeneratif hastalıklarda olduğu gibi PH’nın
oluşumunda da kanıtlanmış tek faktördür. Yaşlılıkta daha fazla tetiklenen
oksidatif stresin dopaminerjik nörotoksisite oluşumunda önemli bir rol oynadığı
düşünülmektedir. Bu derlemede oksidatif stres ve PH arasındaki ilişki
irdelenecektir.

        Gereç ve Yöntem: PH ile
oksidatif stres arasındaki ilişkinin tespiti için yapılmış çalışmaların
kapsamlı olarak derlenebilmesi için sağlık bilimleri alanındaki veri tabanları
kullanılmıştır. Web of Science gibi temel atıf indekslerinde daha önce
yayımlanmış makalelerden yararlanılmıştır.

        Sonuç ve Tartışma: Parkinson
çok sayıda temel hücresel süreci etkileyen genetik ve çevresel faktörlerin
kompleks etkileşiminden kaynaklanan nörodejeneratif bir hastalıktır. Oksidatif
stres genetik bütünlüğü tehdit eder ve PH’nın gelişimine katkı sağlar.
Oksidatif strese bağlı olarak meydana gelen hasar ürünlerinden kaçınmak ve bu
çizgide koruyucu tedavi protokolü çizmek sağlıklı beyin fonksiyonlarının devamı
ve organizmayı Parkinson gibi nörodejeneratif hastalıklardan korumak adına önemli
bir strateji olabilir.

Anahtar Kelimeler

Parkinson hastalığı (PH), oksidatif stres, reaktif oksijen türler (ROT), yaşlanma, nörodejeneratif hastalık

OXIDATIVE STRESS AND PARKINSON DISEASE

Öz

         Objective: Parkinson's
Disease (PD) is a chronic and progressive neurodegenerative disease in the
brain associated with the loss of dopaminergic neurons. Old age is the only
proven factor in the development of PD. It is thought that oxidative stress
which is more triggered in old age plays a vital role in the formation of
dopaminergic neurotoxicity. In this review, the relationship between oxidative
stress and PD will be examined.

        Material and Method: The databases in the health sciences field were
used to compile the studies conducted to determine the relationship between PH
and oxidative stress. Previously published articles such as Web of Science have
been used.

        Result and Discussion: Parkinson's is a neurodegenerative disease
resulting from the complex interaction of genetic and environmental factors that
affect on many basic cellular process. Oxidative stress threatens genetic
integrity and contributes to the development of PH. Avoiding
damage products due to oxidative stress and drawing a protective treatment
protocol may be a crucial strategy for maintaining healthy brain function and
protecting the organism from neurodegenerative diseases such as Parkinson's
disease.

Anahtar Kelimeler

Parkinson's disease (PD), oxidative stress, reactive oxygen species (ROS), aging, neurodegenerative disease

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