DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI

Yıl 2019, Cilt: 43 Sayı: 2, 197 - 208, 01.06.2019

Serdal Kurt

https://doi.org/10.33483/jfpau.472016

Cited By: 1

Öz

        Amaç: Deney hayvanlarında bitkisel kaynaklı antioksidanların kullanımının
fertilite üzerine etkisini araştırmak amaçlandı.

        Gereç ve Yöntem: Bu alanda yapılmış bilimsel çalışmalar
incelendi. Elde edilen bilimsel bilgiler doğrultusunda antioksidan içerikli
bazı bitkilerin deney hayvanlarında fertilite parametrelerine etkileri
derlenmeye çalışıldı. Antioksidanlar, oksidasyonu engelleyen maddeler olarak
tanımlanmaktadır. En yaygın antioksidan maddeler arasında olan A vitamini, C
vitamini, E vitamini ve fenolik bileşiklerin temel kaynağı bitkilerdir.
Antioksidan maddeler, hücresel metabolizma ile mitokondrilerde enerji
üretilmesi sırasında yan ürün olarak açığa çıkan serbest radikalleri nötraliz
ederek zararlı etkilerine karşı vücudu korurlar. Ancak açığa çıkan serbest
radikaller antioksidan maddelerin detoksifiye etme kapasitesini aşarsa
oksidatif stres meydana gelerek hücrelerde Dezoksiribonükleik asit (DNA),
protein ve lipit hasarı ile malignant hücre gelişimine neden olabilir. Dolayısı
ile oksidatif stresin organ ve dokularda hastalık meydana getirmesinin yanında
eşey hücrelerde oluşturduğu fonksiyon bozuklukları ile de reprodüktif sorunlara
yol açmaktadırlar. 

        Sonuç ve
Tartışma: Tavşan, sıçan ve fareler üzerinde
yapılan çalışmalarda nötralize edilemeyen serbest radikallerin fertilite
sorunlarına yol açtığı tespit edilmiştir. Bu alanda yapılan çalışmaların
sonucunda deney hayvanlarında bitkisel kaynaklı antioksidanların kullanımın
sperm, semen, oosit ve embriyo gibi fertilite parametrelerini iyileştirdiği
saptanmıştır.

Anahtar Kelimeler

bitkisel kaynaklı antioksidan, deney hayvanı, fertilite, oksidatif stres

USES OF PLANT-DERIVED ANTIOXIDANTS IN TERMS OF FERTILITY IN EXPERIMENTAL ANIMALS

Öz

Objective: This study was aimed
to investigate the effect of using plant-derived antioxidants on fertility in
experimental animals.

       
Material and Method:
Scientific studies related to this study were investigated. In line with
information obtained, the effects of some antioxidant plants on fertility
parameters of experimental animals were reviewed.

Antioxidants are defined as substances
that inhibits oxidation. The most common antioxidant substances are vitamin A,
vitamin C, vitamin E and phenolic compounds. And also, their main origin are
the plants. Free radicals arise as byproduct during production of energy by
cellular metabolism in mitochondria. Antioxidants neutralize free radicals and
thus protect the body against the harmful effects of oxidants. If the free
radicals exceed detoxification capacity of antioxidant substances, oxidative
stress occurs. Oxidative stress can damage to cellular components such as
deoxyribonucleic acid (DNA), protein and lipids and leads to formation of
malignant cells. So, oxidative stress results in reproductive problems because
it induces functional disorders in sex cells, organs and tissues.

        Result and Discussion: Studies on rabbits, mice, and rats have shown that
non-neutralized free radicals cause reproductive dysfunction In conclusion, it
was determined that the plant-derived antioxidants improve fertility parameters
such as sperm, semen, oocytes and embryos in the experimental animals.

Anahtar Kelimeler

experimental animal, fertility, oxidative stress, plant-derived antioxidants

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