Yıl 2020, Cilt 44 , Sayı 1, Sayfalar 1 - 17 2020-01-31

HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA
PSEUDOMONAS AERUGINOSA İLE ENFEKTE EDİLMİŞ CİVCİVLERİN KARACİĞERİNE POTASYUM 2-((4-AMİNO-5-(MORFOLİNOMETİL)-4H-1,2,4-TRİAZOL-3- İL)TİYO)ASETAT (PKR-173) BİLEŞİĞİNİN DÜZELTİCİ ETKİSİNİN HİSTOLOJİK OLARAK ARAŞTIRILMASI

Yevgenia VASHCHYK [1] , Roman SHCHERBYNA [2] , Volodymyr PARCHENKO [3] , İnna BUSHUEVA [4] , Bogdan GUTYJ [5] , Hanna FOTINA [6] , Tatiana FOTINA [7] , Yuriy STRONSKYI [8]


Objectives: The aim of the research is the histological study of the corrective effect of the compound potassium 2((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3yl)thio)acetate (PKR-173) with different antibiotics on the state of chicken's liver under infection by Pseudomonas aeruginosa.

Materials and Methods: The histological study was carried out on the levers of intact chickens (intact control); chickens that were infected by the strain of Pseudomonas aeruginosa (controlled pathology); chickens that had (before being infected by Pseudomonas aeruginosa) preventive input of the compound PKR-173 with the classic antibiotic Enrofloxacin or with Saroflox (undergoing research); or were input Thiotriazolin with the classic antibiotic Enrofloxacin.

Result and Discussion: As a result, it is stated, that preventive input of the compound PKR-173 with reseachable antibiotic Saroflox, as well as with classic antibiotic Enrofloxacin and Thiotriazolin with antibiotic Enrofloxacin, to chickens infected with pseudomonas aeruginosa, prevents from chickens' livers developng stereotypical morphological changes characteristic of nonspecific reactive hepatitis. Analysis of quantitative characteristics of pathological process that developed in chicken's liver infected with pseudomonas aeruginosa, and the corrective influence of reseached methods showed that the compound PKR-173 with antibiotic Saroflox believably lowers displays of all signs of pathology compared to the controlled pathology. 

Amaç: Araştırmanın amacı, potasyum 2-((4-amino-5-(morfolinometil)-4H-1,2,4-triazol-3-il)tiyo)asetat

(PKR-173) bileşiğinin farklı antibiyotikler ile birlikte Pseudomonas aeruginosa ile enfekte edilmiş civcivlerin

karaciğerine düzeltici etkisinin histolojik olarak incelenmesidir.

Gereç ve Yöntem: Histolojik araştırma, sağlam civcivler (kontrol), Pseudomonas aeruginosa ile enfekte

edilmiş civcivler (kontrol edilen patoloji), (Pseudomonas aeruginosa ile enfekte edilmeden önce) PKR-173

bileşiği ile Enrofloxacin veya Saroflox gibi klasik antibiyotik yada tiotiazolin ile Enrofloxacin antibiyotiği

verilen civcivlerin karaciğeri üzerinde yapılmıştır.

Sonuç ve Tartışma: Araştırmaların sonucunda; araştırılan antibiyotik olan Saroflox ile PKR-173

bileşiğinin ve önleyici bir şekilde Pseudomonas aeruginosa ile enfekte edilmiş civcivlere uygulanan

Enrofloxacin ve Thiotriazolin- Enrofloxacin gibi klasik antibiyotiklein, nonspesifik reaktif hepatite özgü olan

karaciğerdeki standart morfolojik değişiklikleri önlediği tespit edilmiştir. Pseudomonas aeruginosa ile enfekte

edilmiş civcivlerin karaciğerinde gelişen patolojik sürecin kantitatif özelliklerinin analizi ve düzeltici etkisi

araştırılan metot, Saroflox antibiyotiği ile PKR-173 bileşiğinin, kontroldeki patolojiye kıyasla patolojinin bütün

belirtilerini azalttığını göstermiştir.

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Birincil Dil en
Konular Farmakoloji ve Eczacılık
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-5980-6290
Yazar: Yevgenia VASHCHYK
Ülke: Ukraine


Orcid: 0000-0002-9742-0284
Yazar: Roman SHCHERBYNA (Sorumlu Yazar)
Ülke: Ukraine


Orcid: 0000-0002-2283-1695
Yazar: Volodymyr PARCHENKO
Ülke: Ukraine


Orcid: 0000-0002-5336-3900
Yazar: İnna BUSHUEVA
Ülke: Ukraine


Orcid: 0000-0002-5971-8776
Yazar: Bogdan GUTYJ
Ülke: Ukraine


Orcid: 0000-0002-0761-3681
Yazar: Hanna FOTINA
Ülke: Ukraine


Orcid: 0000-0001-5079-2390
Yazar: Tatiana FOTINA
Ülke: Ukraine


Orcid: 0000-0002-4024-0901
Yazar: Yuriy STRONSKYI
Ülke: Ukraine


Tarihler

Yayımlanma Tarihi : 31 Ocak 2020

Bibtex @araştırma makalesi { jfpanu567757, journal = {Journal of Faculty of Pharmacy of Ankara University}, issn = {1015-3918}, eissn = {2564-6524}, address = {Ankara University Faculty of Pharmacy Degol Str. TR-06100 Tandogan/Ankra/TURKEY}, publisher = {Ankara Üniversitesi}, year = {2020}, volume = {44}, pages = {1 - 17}, doi = {10.33483/jfpau.567757}, title = {HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA}, key = {cite}, author = {VASHCHYK, Yevgenia and SHCHERBYNA, Roman and PARCHENKO, Volodymyr and BUSHUEVA, İnna and GUTYJ, Bogdan and FOTINA, Hanna and FOTINA, Tatiana and STRONSKYI, Yuriy} }
APA VASHCHYK, Y , SHCHERBYNA, R , PARCHENKO, V , BUSHUEVA, İ , GUTYJ, B , FOTINA, H , FOTINA, T , STRONSKYI, Y . (2020). HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA. Journal of Faculty of Pharmacy of Ankara University , 44 (1) , 1-17 . DOI: 10.33483/jfpau.567757
MLA VASHCHYK, Y , SHCHERBYNA, R , PARCHENKO, V , BUSHUEVA, İ , GUTYJ, B , FOTINA, H , FOTINA, T , STRONSKYI, Y . "HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA". Journal of Faculty of Pharmacy of Ankara University 44 (2020 ): 1-17 <https://dergipark.org.tr/tr/pub/jfpanu/issue/52196/567757>
Chicago VASHCHYK, Y , SHCHERBYNA, R , PARCHENKO, V , BUSHUEVA, İ , GUTYJ, B , FOTINA, H , FOTINA, T , STRONSKYI, Y . "HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA". Journal of Faculty of Pharmacy of Ankara University 44 (2020 ): 1-17
RIS TY - JOUR T1 - HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA AU - Yevgenia VASHCHYK , Roman SHCHERBYNA , Volodymyr PARCHENKO , İnna BUSHUEVA , Bogdan GUTYJ , Hanna FOTINA , Tatiana FOTINA , Yuriy STRONSKYI Y1 - 2020 PY - 2020 N1 - doi: 10.33483/jfpau.567757 DO - 10.33483/jfpau.567757 T2 - Journal of Faculty of Pharmacy of Ankara University JF - Journal JO - JOR SP - 1 EP - 17 VL - 44 IS - 1 SN - 1015-3918-2564-6524 M3 - doi: 10.33483/jfpau.567757 UR - https://doi.org/10.33483/jfpau.567757 Y2 - 2019 ER -
EndNote %0 Ankara Üniversitesi Eczacılık Fakültesi Dergisi HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA %A Yevgenia VASHCHYK , Roman SHCHERBYNA , Volodymyr PARCHENKO , İnna BUSHUEVA , Bogdan GUTYJ , Hanna FOTINA , Tatiana FOTINA , Yuriy STRONSKYI %T HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA %D 2020 %J Journal of Faculty of Pharmacy of Ankara University %P 1015-3918-2564-6524 %V 44 %N 1 %R doi: 10.33483/jfpau.567757 %U 10.33483/jfpau.567757
ISNAD VASHCHYK, Yevgenia , SHCHERBYNA, Roman , PARCHENKO, Volodymyr , BUSHUEVA, İnna , GUTYJ, Bogdan , FOTINA, Hanna , FOTINA, Tatiana , STRONSKYI, Yuriy . "HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA". Journal of Faculty of Pharmacy of Ankara University 44 / 1 (Ocak 2020): 1-17 . https://doi.org/10.33483/jfpau.567757
AMA VASHCHYK Y , SHCHERBYNA R , PARCHENKO V , BUSHUEVA İ , GUTYJ B , FOTINA H , FOTINA T , STRONSKYI Y . HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA. Ankara Ecz. Fak. Derg.. 2020; 44(1): 1-17.
Vancouver VASHCHYK Y , SHCHERBYNA R , PARCHENKO V , BUSHUEVA İ , GUTYJ B , FOTINA H , FOTINA T , STRONSKYI Y . HISTOLOGICAL STUDY OF A CORRECTIVE INFLUENCE OF A COMPOUND POTASSIUM 2-((4-AMINO-5-(MORPHOLINOMETHYL)- 4H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE (PKR-173) ON THE STATE OF CHICKEN'S LIVER UNDER INFECTION BY PSEUDOMONAS AERUGINOSA. Journal of Faculty of Pharmacy of Ankara University. 2020; 44(1): 17-1.