Yıl 2020, Cilt 44 , Sayı 1, Sayfalar 33 - 49 2020-01-31

FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION
OKÜLER UYGULAMA İÇİN VORİKONAZOL YÜKLÜ İN SİTU JELLERİN FORMÜLASYONU VE DETAYLI KARAKTERİZASYONU

Neslihan ÜSTÜNDAĞ OKUR [1] , Vildan YOZGATLI [2] , Zeynep ŞENYİĞİT [3]


Objective: This study was aimed to prepare, characterize and evaluate in situ gel formulation for a sustained ocular delivery of voriconazole.

Material and Method: In situ gels were prepared with three different hydrophilic co-polymers: Poloxamer 188, 407 and 388. The formulations were characterized in terms of their clarity, pH, viscosity drug content uniformity and mechanical/rheological properties. Moreover, in vitro drug release and stabilitystudies were performed.

Result and Discussion: The results showed that the optimized in situ gel formulation had desired in vitro properties and a good stability over the period of 3 months. Texture profile analysis presented that formulations offered suitable adhesive and mechanical properties. P2-V formulation exhibited pseudo-plastic flow and typical gel-type mechanical spectra (G′ > G″) at different frequecy values and at different temperatures. Moreover, all formulations showed a sustained drug release for 24 hours. In conclusion, voriconazole loaded in situ gel could be offered as an encouraging strategy as ocular systems for ocular infections treatment.

mechanical properties poloxamer, rheological properties, thermo-sensitive in situ gel
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Birincil Dil en
Konular Farmakoloji ve Eczacılık
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-3210-3747
Yazar: Neslihan ÜSTÜNDAĞ OKUR (Sorumlu Yazar)
Kurum: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0001-8018-6500
Yazar: Vildan YOZGATLI
Kurum: EGE ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0002-4920-2469
Yazar: Zeynep ŞENYİĞİT
Kurum: İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
Ülke: Turkey


Teşekkür The authors would like to thank to the BASF for providing the poloxamers.
Tarihler

Yayımlanma Tarihi : 31 Ocak 2020

Bibtex @araştırma makalesi { jfpanu586590, journal = {Journal of Faculty of Pharmacy of Ankara University}, issn = {1015-3918}, eissn = {2564-6524}, address = {Ankara University Faculty of Pharmacy Degol Str. TR-06100 Tandogan/Ankra/TURKEY}, publisher = {Ankara Üniversitesi}, year = {2020}, volume = {44}, pages = {33 - 49}, doi = {10.33483/jfpau.586590}, title = {FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION}, key = {cite}, author = {ÜSTÜNDAĞ OKUR, Neslihan and YOZGATLI, Vildan and ŞENYİĞİT, Zeynep} }
APA ÜSTÜNDAĞ OKUR, N , YOZGATLI, V , ŞENYİĞİT, Z . (2020). FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION. Journal of Faculty of Pharmacy of Ankara University , 44 (1) , 33-49 . DOI: 10.33483/jfpau.586590
MLA ÜSTÜNDAĞ OKUR, N , YOZGATLI, V , ŞENYİĞİT, Z . "FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION". Journal of Faculty of Pharmacy of Ankara University 44 (2020 ): 33-49 <https://dergipark.org.tr/tr/pub/jfpanu/issue/52196/586590>
Chicago ÜSTÜNDAĞ OKUR, N , YOZGATLI, V , ŞENYİĞİT, Z . "FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION". Journal of Faculty of Pharmacy of Ankara University 44 (2020 ): 33-49
RIS TY - JOUR T1 - FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION AU - Neslihan ÜSTÜNDAĞ OKUR , Vildan YOZGATLI , Zeynep ŞENYİĞİT Y1 - 2020 PY - 2020 N1 - doi: 10.33483/jfpau.586590 DO - 10.33483/jfpau.586590 T2 - Journal of Faculty of Pharmacy of Ankara University JF - Journal JO - JOR SP - 33 EP - 49 VL - 44 IS - 1 SN - 1015-3918-2564-6524 M3 - doi: 10.33483/jfpau.586590 UR - https://doi.org/10.33483/jfpau.586590 Y2 - 2019 ER -
EndNote %0 Ankara Üniversitesi Eczacılık Fakültesi Dergisi FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION %A Neslihan ÜSTÜNDAĞ OKUR , Vildan YOZGATLI , Zeynep ŞENYİĞİT %T FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION %D 2020 %J Journal of Faculty of Pharmacy of Ankara University %P 1015-3918-2564-6524 %V 44 %N 1 %R doi: 10.33483/jfpau.586590 %U 10.33483/jfpau.586590
ISNAD ÜSTÜNDAĞ OKUR, Neslihan , YOZGATLI, Vildan , ŞENYİĞİT, Zeynep . "FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION". Journal of Faculty of Pharmacy of Ankara University 44 / 1 (Ocak 2020): 33-49 . https://doi.org/10.33483/jfpau.586590
AMA ÜSTÜNDAĞ OKUR N , YOZGATLI V , ŞENYİĞİT Z . FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION. Ankara Ecz. Fak. Derg.. 2020; 44(1): 33-49.
Vancouver ÜSTÜNDAĞ OKUR N , YOZGATLI V , ŞENYİĞİT Z . FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION. Journal of Faculty of Pharmacy of Ankara University. 2020; 44(1): 49-33.