MICROWAVE SYNTHESIS OF NEW 3-(ALKYLTHIO)-5-(THIOPHEN2-YLMETHYL)-1,2,4-TRIAZOL-4-AMINES

Yıl 2020, Cilt: 44 Sayı: 1, 89 - 98, 31.01.2020

Andrey Safonov

https://doi.org/10.33483/jfpau.620599

Cited By: 5

Öz

Objectives: The purpose of this work is to synthesize N-R-3-(alkylthio)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-4-amines
by the Milestone Flexi Wave microwave synthesis system and to prove structure
synthesized compounds.

Materials and Methods: The initial compounds 4-R1-3-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-5-thioles
(1-5) were synthesized at the Department of Toxicological and Inorganic
Chemistry of the Zaporizhzhya State Medical University (Ukraine ). Milestone Flexi Wave microwave synthesis system was
used to synthesize
N-R-3-(alkylthio)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-4-amines. The
elemental analysis of synthesized compounds was established by the universal
analyzer Elementar Vario L cube (CHNS). The 1H spectra (at 400 MHz and 100 MHz)
were recorded in DMSO-d6 on a Varian MR-400 spectrometer and analysed with
ADVASP™ Analyzer program. The completeness of the reactions and the
individuality of the resulting compounds were controlled by the gas
chromatograph Agilent 7890B with a 5977B mass spectrometry detector.

Result and Discussion: The reaction was carried out in an
alcoholic medium by adding a catalytic amount of HCl to 4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols.
Methyl and i-propyl alcohols were used as alcohols. The mixture was heated for
45 minutes at a temperature of 150 ° C, a pressure 14.4 bar, ΔMW = 200 W.

The signals of 1H NMR for (4a-b, 6a-j) are consented with the proposed
structure.

The elemental analysis (CHNS) was accomplished for synthesized compounds
to confirm their basic chemical structures and revealed acceptable agreement
with the calculated percentages.

Anahtar Kelimeler

synthesis, 1HNMR, gas chromatography, 1.2.4-triazole, heterocyclic compounds

Teşekkür

We're grateful to the Zaporizhzhia State Medical University for providing some facilities in carrying out the research.

YENİ 3-(ALKİLTİYO)-5-(TİYOFEN-2-İLMETİL)-1,2,4-TRİAZOL-4-AMİNLERİN MİKRODALGA SENTEZİ

Öz

Amaç: Bu çalışmanın amacı, Milestone Flexi Wave mikrodalga sentez sistemi ile 3-(alkiltiyo)-5-(tiyofen-2-ilmetil)-1,2,4-triazol-4-aminlerin sentezlenmesi ve sentezlenen bileşiklerin yapısının onaylanmasıdır.

Gereç ve Yöntem: İlk bileşikler 3-(tiyofen-2-ilmetil)-4H-1,2,4-triazol-5-tiyoller (1-5) Zaporizhzhya State Medical Üniversite Toksikolojik ve İnorganik Kimya Anabilim Dalı'nda sentezlendi (Ukrayna). 3-(alkiltiyo)-5-(tiyofen-2-ilmetil)-1,2,4-triazol-4-aminlerin sentezlenmesi için Milestone Flexi Wave mikrodalga sentez sistemi kullanıldı. Sentezlenen
bileşiklerin element analizi evrensel analiz Elementar Vario L küpü (CHNS)
tarafından yapıldı. ¹H spektrumları (400 MHz ve 100 MHz'de), DMSO-d₆'da
bir Varian MR-400 spektrometresi üzerinde kaydedildi ve ADVASP ™ Analyzer
programı ile analiz edildi. Reaksiyonlar ve elde edilen bileşikler, bir 5977B
kütle spektrometre detektörü ile Agilent 7890B gaz kromatografısinde  kontrol edildi.

Sonuç
ve Tartışma:
Reaksiyon, 5-(tiyofen-2-ilmetil)-4H-1,2,4-triazol-3-tiyollere katalitik
miktarda HCI ilave edilerek alkollü bir ortamda gerçekleştirildi. Alkol olarak
metil ve i-propil alkoller kullanıldı.

Karışım, 45 dakika boyunca 150°C
sıcaklıkta, 14.4 bar basınçta, ΔMW = 200 W sıcaklıkta ısıtıldı.

Çözücü olarak asetik asit
kullanıldı. (4a-b, 6a-j) için önerilen yapı, ¹H
NMR sinyalleri ile doğrulandı. Temel
kimyasal yapılarını doğrulamak için sentezlenen bileşikler üzerinde element
analizi (CHNS) yapıldı ve hesaplanan yüzdelerle kabul edilebilir bir uyum
sağladığını gösterdi.

Anahtar Kelimeler

1.2.4-triazol, sentez, 1H-NMR, gaz kromatografisi, heterosiklik bileşikler

Kaynakça

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