SYNTHESIS AND ANTIRADICAL ACTIVITY OF ALKYL DERIVATIVES OF 5-(5-METHYL-1H-PYRAZOL-3-YL)-4-PHENYL-4H1,2,4-TRIAZOLE-3-THIOL

Yıl 2020, Cilt: 44 Sayı: 2, 211 - 219, 31.05.2020

Andrey Gotsulya

https://doi.org/10.33483/jfpau.616116

Cited By: 4

Öz

Objective: The aim of the work was to develop effective methods for the synthesis of biologically active heterocyclic systems containing 1,2,4-triazole and pyrazole.

Material and Method: Chemical structures of synthesized compounds were characterized with elemental analysis, IR, 1H-NMR, LC-MS techniques. The antiradical activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay.

Result and Discussion: Developed optimal methods of obtaining of alkylderivatives of 5-(5-methyl-1H-pyrazol-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol. A number of synthesized compounds showed moderate antiradical activity.

Anahtar Kelimeler

antiradical activity, pyrazole, synthesis, 1.2.4-triazoles

5-(5-METİL-1H-PİRAZOL-3-İL)-4-FENİL-4H-1,2,4-TRİAZOL-3-TİYOL ALKİL TÜREVLERİNİN SENTEZ VE ANTİRADİKAL AKTİVİTELERİ

Öz

Amaç: Çalışmanın amacı biyolojik olarak aktif 1,2,4-triazol ve pirazol içeren heterosiklik sistemlerin sentezi için etkili yöntemler geliştirmektir.

Gereç ve Yöntem: Sentezlenen bileşiklerin kimyasal yapıları elemantal analiz, IR, 1H-NMR, LC-MS teknikleri ile karakterize edildi. Antiradikal aktivite 2,2-difenil-1-pikrilhidrazil (DPPH) radikal süpürücü aktivite deneyi kullanılarak değerlendirildi.

Sonuç ve Tartışma: 5-(5-metil-1H-pirazol-3-il)-4-fenil-4H-1,2,4-triazol-3-tiyol alkil türevlerinin elde edilmesi için optimum yöntemler geliştirildi. Bir dizi sentezlenmiş bileşik, orta derecede antiradikal aktivite göstermiştir.

Anahtar Kelimeler

antiradikal aktivite, pirazol, sentez, 1.2.4-triazol

Kaynakça

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