PROLİPOZOM TEKNOLOJİSİNDEKİ GÜNCEL GELİŞMELER VE UYGULAMALAR

Yıl 2020, Cilt: 44 Sayı: 2, 308 - 333, 31.05.2020

Zerrin Sezgin Bayındır Nadir Dereli

https://doi.org/10.33483/jfpau.650028

Öz

Amaç: Lipozomlar, ilaç taşıyıcı sistemler arasında en umut verici ve uygulanabilir olanıdır. Ancak, lipozomların fiziksel ve kimyasal stabilite problemleri kullanımlarını sınırlamaktadır. Bu problemlerin üstesinden gelmek için 1986 yılında prolipozomal sistemler geliştirilmiştir. Bu derleme kapsamında prolipozomal ilaç taşıyıcı sistemler ve uygulamaları ile ilgili yapılmış olan bilimsel araştırmalar akademik veri tabanları taranarak sunulmuştur.

Sonuç ve Tartışma: Prolipozomlar etkin madde, suda çözünür taşıyıcı materyal ve fosfolipitlerden oluşan, su veya biyolojik sıvılar ile temas ettiğinde çok katmanlı lipozomal süspansiyon oluşturan toz veya sıvı lipit yapıdaki ürünlerdir. Bu derlemede, ilaç taşıyıcı sistemler olarak kullanılan prolipozomlar hakkında genel bilgiler verilmiştir. Prolipozomların hazırlanmasında kullanılan bileşenler ve özellikleri tanımlanmıştır. Prolipozomların hazırlama teknolojileri, karakterizasyonu ve avantajlarına değinilmiştir. Derlemenin son bölümünde prolipozomların oral, parenteral, pulmoner, transdermal ve mukozal yollardan uygulanmaları ile ilgili çalışmalar özetlenmiştir. Prolipozomlar üstün in vivo etkinlikleri, yüksek stabiliteleri ve endüstriyel boyutta imal edilebilir olmaları nedeniyle umut verici ilaç taşıyıcı sistemlerdir.

Anahtar Kelimeler

ilaç taşıyıcı sistemler, lipozom, prolipozomlar, stabilite

RECENT DEVELOPMENTS ON PROLIPOSOME TECHNOLOGY AND APPLICATIONS

Öz

Objective: Liposomes are the most promising and feasible carriers among other drug delivery systems. However, physical and chemical stability problems of liposomes limit their use. In order to overcome these problems, proliposomal systems were developed in 1986. Within the scope of this review, scientific researches about proliposomal drug delivery systems and their applications were presented by searching academic databases.

Result and Discussion: Proliposomes are powder or liquid lipid formulations of active agent, water-soluble carrier material and phospholipids, which form a multilamellar liposomal suspension upon contact with water or biological fluids. In this review, general information about proliposomes as drug delivery systems were given. The components used in the preparation of proliposomes and their properties were described. The preparation technologies, characterization and advantages of proliposomes were discussed. In the last part of the review, studies on the administration of proliposomes by oral, parenteral, pulmonary, transdermal and mucosal routes were summarized. Proliposomes are promising drug delivery systems because of their superior in vivo efficacy, high stability and industrial fabricability.

Anahtar Kelimeler

drug delivery systems, liposome, proliposomes, stability

Kaynakça

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