TOPOISOMERASE II ENZYME INHIBITORS

Yıl 2020, Cilt: 44 Sayı: 2, 356 - 372, 31.05.2020

Oğuzhan Fırat , İlkay Yıldız

https://doi.org/10.33483/jfpau.696349

Öz

Objective: The use of topoisomerase II enzyme inhibitors, which have increased in importance in recent years, has been evaluated in terms of pharmaceutical chemistry and clinical use. In this context, compounds with clinical uses as well as certain compounds which are in the developmental stage are included.

Result and Discussion: Topoisomerase II enzyme inhibition targeted cancer chemotherapy and drug development efforts that are suitable for this mechanism, demonstrating high activity and less adverse effects have been ongoing for many years. As a conclusion, it provides clinical use of many new agents in high activity by making appropriate modifications on the chemical structure of topoisomerase II inhibitors obtained herbally or synthetically. In addition, preventing drug resistance frequently seen in cancer patients, targeted treatment and reduced toxicities can be provided with the discovery of new agents. By ensuring that the use of new agents is among the individualized treatment methods, the most appropriate treatment will be provided to the patients.

Anahtar Kelimeler

anticancer, clinical pharmacy, topoisomerase II

TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ

Öz

Amaç: Son yıllarda önemi daha da artan topoizomeraz II enzim inhibitörleri’nin Farmasötik Kimya bilimi açısından ve klinik kullanımları değerlendirilmiştir. Bu bağlamda, klinik kullanımları olan bileşiklerin yanında geliştirilme aşamasında olan bazı bileşiklere de yer verilmiştir.

Sonuç ve Tartışma: Topoizomeraz II enzimi inhibisyonu hedefli kanser kemoterapisi ve bu mekanizmaya uygun, aktivitesi yüksek olup advers etkileri az olan ilaç geliştirme çabaları uzun yıllardır devam eden bir süreçtir. Sonuç olarak, bitkisel veya sentetik olarak elde edilen topoizomeraz II inhibitörlerinin kimyasal yapıları üzerinde uygun modifikasyonların yapılması, yüksek aktivitede birçok yeni ajanın klinik kullanımını mümkün kılmaktadır. Ayrıca kanser hastalarında sıklıkla görülen ilaç direncinin önüne geçilmesi, hedefe yönelik tedavi ve toksisitelerin azaltılması yeni ajanların keşfiyle sağlanabilecektir.Yeni ajanların kullanımının bireyselleştirilmiş tedavi yöntemleri arasında bulunmasının sağlanması ile hastalara en uygun tedavi sunulabilecektir.

Anahtar Kelimeler

antikanser, klinik eczacılık, topoizomeraz II

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