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ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI

Yıl 2021, Cilt: 45 Sayı: 1, 70 - 95, 18.01.2021
https://doi.org/10.33483/jfpau.773430

Öz

Amaç: Nanoteknolojnin hastalıkların teşhis ve tedavisinde kullanımı giderek artan bir şekilde ilgi görmektedir. Altın nanopartiküller (AuNP) sahip oldukları üstün özellikler sayesinde çeşitli kanser türlerinin teşhis ve tedavisinde kullanılmaktadırlar. Bu derleme kapsamında AuNP’ler hakkında genel bilgiler, kanserde kullanımlarına ilişkin olan bilimsel çalışmalar ve kaydedilen son gelişmeler akademik veri tabanları taranarak sunulmuştur.
Sonuç ve Tartışma: AuNP’lerin benzersiz optik, elektriksel ve fizikokimyasal özellikleri sayesinde bu sistemler kanser teşhis ve tedavisinde ilaç taşıyıcı sistem, görüntüleme ajanı, fototermal tedavi, fotodinamik tedavi ve biyosensör olarak kullanılmaktadır. AuNP sentezinin kolay olması ve pek çok ligand için yüzey modifikasyonuna elverişli olması bu kullanım alanları için büyük fayda sağlamaktadır. Bu özellikleri sayesinde AuNP’ler kanser tedavisinde umut verici sistemler olarak ön plana çıkmaktadır.

Kaynakça

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GOLD NANOPARTICULES AND USES IN CANCER

Yıl 2021, Cilt: 45 Sayı: 1, 70 - 95, 18.01.2021
https://doi.org/10.33483/jfpau.773430

Öz

Objective: Nanotechnology has become more and more potentially used in diagnosis or treatment of diseases. Gold nanoparticles (AuNP) are used in the diagnosis and treatment of various cancer types thanks to their superior properties. Within the scope of this review, general information about AuNPs, scientific studies on their use in cancer and recent developments have been presented by scanning academic databases.
Result and Discussion: By means of the unique optical, electrical and physicochemical properties of AuNPs, it is used as a drug delivery system, imaging agent, photothermal therapy, photodynamic therapy and biosensor in cancer diagnosis and treatment. The fact that AuNP synthesis is easy and the nanoparticle surface is suitable for modification with many ligands provides great benefits for these applications. Thanks to these features, AuNPs come to the fore as promising systems in cancer treatment.

Kaynakça

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  • Nouri, S., Mohammadi, E., Mehravi, B., Majidi, F., Ashtari, K., Neshasteh-Riz, A., & Einali, S. (2019). NIR triggered glycosylated gold nanoshell as a photothermal agent on melanoma cancer cells. Artificial cells, nanomedicine, and biotechnology, 47(1), 2316-2324.
  • Majidi, F. S., Mohammadi, E., Mehravi, B., Nouri, S., Ashtari, K., & Neshasteh-riz, A. (2019). Investigating the effect of near infrared photo thermal therapy folic acid conjugated gold nano shell on melanoma cancer cell line A375. Artificial cells, nanomedicine, and biotechnology, 47(1), 2161-2170.
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  • Calavia, P. G., Chambrier, I., Cook, M. J., Haines, A. H., Field, R. A., & Russell, D. A. (2018). Targeted photodynamic therapy of breast cancer cells using lactose-phthalocyanine functionalized gold nanoparticles. Journal of colloid and interface science, 512, 249-259.
  • Amini, S. M., Kharrazi, S., Hadizadeh, M., Fateh, M., & Saber, R. (2013). Effect of gold nanoparticles on photodynamic efficiency of 5-aminolevolenic acid photosensitiser in epidermal carcinoma cell line: an in vitro study. IET nanobiotechnology, 7(4), 151-156.
  • Prasanna, S. W., Poorani, G., Kumar, M. S., Aruna, P., & Ganesan, S. (2014). Photodynamic efficacy of Rosebengal-gold nanoparticle complex on Vero and HeLa cell lines. Materials Express, 4(5), 359-366.
  • Bahrami, B., Hojjat-Farsangi, M., Mohammadi, H., Anvari, E., Ghalamfarsa, G., Yousefi, M., & Jadidi-Niaragh, F. (2017). Nanoparticles and targeted drug delivery in cancer therapy. Immunology Letters, 190, 64-83.
  • Alexander, C. M., Hamner, K. L., Maye, M. M., & Dabrowiak, J. C. (2014). Multifunctional DNA-gold nanoparticles for targeted doxorubicin delivery. Bioconjugate chemistry, 25(7), 1261-1271.
  • Khutale, G. V., & Casey, A. (2017). Synthesis and characterization of a multifunctional gold-doxorubicin nanoparticle system for pH triggered intracellular anticancer drug release. European Journal of Pharmaceutics and Biopharmaceutics, 119, 372-380.
  • Shaat, H., Mostafa, A., Moustafa, M., Gamal-Eldeen, A., Emam, A., El-Hussieny, E., & Elhefnawi, M. (2016). Modified gold nanoparticles for intracellular delivery of anti-liver cancer siRNA. International journal of pharmaceutics, 504(1-2), 125-133.
  • Kim, C. K., Ghosh, P., & Rotello, V. M. (2009). Multimodal drug delivery using gold nanoparticles. Nanoscale, 1(1), 61-67.
  • Bao, Q. Y., Geng, D. D., Xue, J. W., Zhou, G., Gu, S. Y., Ding, Y., & Zhang, C. (2013). Glutathione-mediated drug release from Tiopronin-conjugated gold nanoparticles for acute liver injury therapy. International journal of pharmaceutics, 446(1-2), 112-118.
  • Yoon, J. H., Ganbold, E. O., & Joo, S. W. (2016). PEGylation density-modulated anticancer drug release on gold nanoparticles in live cells. Journal of Industrial and Engineering Chemistry, 33, 345-354.
  • Sreejivungsa, K., Suchaichit, N., Moosophon, P., & Chompoosor, A. (2016). Light-regulated release of entrapped drugs from photoresponsive gold nanoparticles. Journal of Nanomaterials, 2016.
  • Chen, X., Han, W., Zhao, X., Tang, W., & Wang, F. (2019). Epirubicin-loaded marine carrageenan oligosaccharide capped gold nanoparticle system for pH-triggered anticancer drug release. Scientific reports, 9(1), 1-10.
  • Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016). Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharmaceutical research, 33(10), 2373-2387.
  • Cytimmune Web Site. Retrieved April 10, 2020, from http://cytimmune.com/#pipeline
  • Libutti, S. K., Paciotti, G. F., Byrnes, A. A., Alexander, H. R., Gannon, W. E., Walker, M., Seidel, G.D., Yuldasheva, N., Tamarkin, L. (2010). Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine. Clinical cancer research, 16(24), 6139-6149.
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  • Paithankar, D., Hwang, B. H., Munavalli, G., Kauvar, A., Lloyd, J., Blomgren, R., Faupel, L., Meyer, T., Mitragotri, S. (2015). Ultrasonic delivery of silica–gold nanoshells for photothermolysis of sebaceous glands in humans: Nanotechnology from the bench to clinic. Journal of Controlled Release, 206, 30-36.
  • Farooq, M. U., Novosad, V., Rozhkova, E. A., Wali, H., Ali, A., Fateh, A. A.,Neogi, P.M., Neogi, A., Wang, Z. (2018). Gold nanoparticles-enabled efficient dual delivery of anticancer therapeutics to HeLa cells. Scientific reports, 8(1), 2907.
  • Zhao, Y., Zhao, W., Lim, Y. C., & Liu, T. (2019). Salinomycin-Loaded Gold Nanoparticles for Treating Cancer Stem Cells by Ferroptosis-Induced Cell Death. Molecular pharmaceutics.
  • Guan, Y. H., Tian, M., Liu, X. Y., & Wang, Y. N. (2019). Preparation of novel cisplatin‐conjugated hollow gold nanospheres for targeting cervical cancer. Journal of cellular physiology, 234(9), 16475-16484.
  • Manivasagan, P., Bharathiraja, S., Bui, N. Q., Lim, I. G., & Oh, J. (2016). Paclitaxel-loaded chitosan oligosaccharide-stabilized gold nanoparticles as novel agents for drug delivery and photoacoustic imaging of cancer cells. International journal of pharmaceutics, 511(1), 367-379.
  • Dhamecha, D., Jalalpure, S., Jadhav, K., Jagwani, S., & Chavan, R. (2016). Doxorubicin loaded gold nanoparticles: Implication of passive targeting on anticancer efficacy. Pharmacological research, 113, 547-556
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  • Kong, L., Qiu, J., Sun, W., Yang, J., Shen, M., Wang, L., & Shi, X. (2017b). Multifunctional PEI-entrapped gold nanoparticles enable efficient delivery of therapeutic siRNA into glioblastoma cells. Biomaterials science, 5(2), 258-266.
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  • Khademi, K., Sarkar, S., Shakeri-Zadeh, A., Attaran, N., Kharrazi, S., Ay, M., Azimian, H., & Ghadiri, H. (2019). Targeted gold nanoparticles enable molecular CT imaging of head and neck cancer: An in vivo study. International journal of nanomedicine, 6, 2859.
  • Cheng, Y., Dai, Q., Morshed, R. A., Fan, X., Wegscheid, M. L., Wainwright, D. A.,Han,Y., Zhang, L., Auffinger, B., Tobias, L. A., Rincón, E., Thaci, B., Ahmed, A.U., Warnke, P.C., He, C., Lesniak, M.S. (2014). Blood‐brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging. Small, 10(24), 5137-5150.
  • Anselmo, A. C., & Mitragotri, S. (2016). Nanoparticles in the clinic. Bioeng Transl Med 1: 10–29.
  • Nanospectra Web Site. Retrieved May 10, 2020, from https://nanospectra.com/
  • Jensen, S. A., Day, E. S., Ko, C. H., Hurley, L. A., Luciano, J. P., Kouri, F. M.,Merkel, T.J., Luthi, A.J., Patel, P.C., Cutler, J.I., Daniel, W.L., Scott, A.W., Rotz, M.W., Meade, T. J., Giljohann, D.A., Mirkin, C.A., Stegh, A.H. (2013). Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma. Science translational medicine, 5(209), 209ra152-209ra152.
  • nephroHUB Web Site. Retrieved May 13, 2020, from http://www.nephrohub.org/our-cores/core-b-kidney-therapeutic-design development/index.html
  • Amal, H., Leja, M., Funka, K., Skapars, R., Sivins, A., Ancans, G., Liepniece-Karele, I.,Kikuste, I., Lasina, L., Haick, H. (2016). Detection of precancerous gastric lesions and gastric cancer through exhaled breath. Gut, 65(3), 400-407.
  • Luminex Web Site, Retrieved May 29, 2020, from https://www.luminexcorp.com/verigene-nanogrid-technology/
  • ClinicalTrials Web Site, Retrieved Jul 05, 2020, from https://clinicaltrials.gov/
  • Conde, J., Doria, G., & Baptista, P. (2012). Noble metal nanoparticles applications in cancer. Journal of drug delivery, 2012.
Toplam 100 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Eczacılık ve İlaç Bilimleri
Bölüm Derleme
Yazarlar

Hatice Demirtaş Bu kişi benim 0000-0001-6626-2538

Ceyda Şengel Türk 0000-0003-4123-7226

Yayımlanma Tarihi 18 Ocak 2021
Gönderilme Tarihi 24 Temmuz 2020
Kabul Tarihi 23 Ekim 2020
Yayımlandığı Sayı Yıl 2021 Cilt: 45 Sayı: 1

Kaynak Göster

APA Demirtaş, H., & Şengel Türk, C. (2021). ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI. Journal of Faculty of Pharmacy of Ankara University, 45(1), 70-95. https://doi.org/10.33483/jfpau.773430
AMA Demirtaş H, Şengel Türk C. ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI. Ankara Ecz. Fak. Derg. Ocak 2021;45(1):70-95. doi:10.33483/jfpau.773430
Chicago Demirtaş, Hatice, ve Ceyda Şengel Türk. “ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI”. Journal of Faculty of Pharmacy of Ankara University 45, sy. 1 (Ocak 2021): 70-95. https://doi.org/10.33483/jfpau.773430.
EndNote Demirtaş H, Şengel Türk C (01 Ocak 2021) ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI. Journal of Faculty of Pharmacy of Ankara University 45 1 70–95.
IEEE H. Demirtaş ve C. Şengel Türk, “ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI”, Ankara Ecz. Fak. Derg., c. 45, sy. 1, ss. 70–95, 2021, doi: 10.33483/jfpau.773430.
ISNAD Demirtaş, Hatice - Şengel Türk, Ceyda. “ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI”. Journal of Faculty of Pharmacy of Ankara University 45/1 (Ocak 2021), 70-95. https://doi.org/10.33483/jfpau.773430.
JAMA Demirtaş H, Şengel Türk C. ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI. Ankara Ecz. Fak. Derg. 2021;45:70–95.
MLA Demirtaş, Hatice ve Ceyda Şengel Türk. “ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI”. Journal of Faculty of Pharmacy of Ankara University, c. 45, sy. 1, 2021, ss. 70-95, doi:10.33483/jfpau.773430.
Vancouver Demirtaş H, Şengel Türk C. ALTIN NANOPARTİKÜLLER VE KANSERDE KULLANIMLARI. Ankara Ecz. Fak. Derg. 2021;45(1):70-95.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.