SYNTHESIS OF INDOLES DERIVATIVES USING METAL FREE CATALYST IN ORGANIC REACTIONS

Yıl 2021, Cilt: 45 Sayı: 3, 615 - 630, 27.09.2021

Ratnesh Das Hemlata Dangi Sushil Kashaw

https://doi.org/10.33483/jfpau.873623

Öz

Objective: Indole derivatives are one of the most flexible and common nitrogen-based skeletons and often used in the synthesis of numerous heterocyclic compounds, having biological or medicinal importance. Many indole derivatives have been isolated naturally from plants, fungi, and marine organisms and are highly important due to their pharmaceutical activities. They also play a significant character in polymer and dye industries as well as in the agriculture sector. There exists an immense potential for designing and methodology development for the synthesis of indole based heterocyclic scaffold structure with desire chemical and biomedical relevance.

Result and Discussion: In this present review, we outlined the recent applications of indoles in the one-pot multi-component reaction using metal free catalysts for the preparation of various heterocyclic scaffolds and their corresponding biological activities are also discussed.

Anahtar Kelimeler

Indole derivatives, metal free catalyst, one pot multi-component reaction, synthesis

Destekleyen Kurum

Dr. Harisingh Gour Central University Sagar MP 470003

Proje Numarası

Nil

Teşekkür

Thankful CSIR, Delhi India for giving me a NET-JRF fellowship grant.

ORGANİK REAKSİYONLARDA METAL İÇERMEYEN KATALİZÖR KULLANILARAK İNDOL TÜREVLERİNİN SENTEZİ

Öz

Amaç: İndol türevleri azot bazlı iskeletlerden biridir ve biyolojik veya tıbbi önemi olan birçok heterosiklik bileşiğin sentezinde sıklıkla kullanılır. Birçok indol türevi bitkilerden, mantarlardan ve deniz organizmalarından doğal olarak izole edilmiştir ve farmasötik aktiviteleri nedeniyle oldukça önemlidirler. Ayrıca polimer ve boya endüstrilerinde ve tarım sektöründe de önemli rol oynarlar. İstenen kimyasal ve biyomedikal özelliklere sahip indol bazlı heterosiklik iskelet yapısının sentezi için tasarım ve metodoloji geliştirmeye ihtiyaç vardır.

Sonuç ve Tartışma: Bu derlemede, çeşitli heterosiklik yapı iskeletlerinin hazırlanması için metal içermeyen katalizörlerin kullanıldığı, tek kap çok bileşenli reaksiyonlarla indollerin son uygulamaları özetlenmiştir ve bunlara karşılık gelen biyolojik aktiviteler tartışılmıştır.

Anahtar Kelimeler

Indol türevleri, metalsiz katalizör, sentez, tek potalı çok bileşenli reaksiyon

Proje Numarası

Nil

Kaynakça

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