SPECTROPHOTOMETRIC DETERMINATION OF ACTIVE COMPOUNDS IN AN ANTIHYPERTENSIVE FORMULATION BY HAAR-CWT METHOD

Yıl 2021, Cilt: 45 Sayı: 3, 535 - 544, 27.09.2021

Özgür Üstündağ Erdal Dinç

https://doi.org/10.33483/jfpau.986786

Öz

Objective: In present work, we developed a new wavelet method (HAAR-CWT) to determine the amounts of irbesartan (IR) and hydrochlorotizide (HC) active compounds simultaneously in an antihypertensive formulation, and after validating this method, we successfully applied it to the assay of tablets containing the above-mentioned compounds.

Material and Method: The absorption spectra of mixtures and tablet solutions in the spectral range 200-305 nm were measured by a Shimadzu UV-1601 dual-beam UV-VIS spectrophotometer.

Result and Discussion: Due to the strong overlapping spectra of the mentioned components, the HAAR-CWT method has been proposed and successfully applied to the ratio spectra of IR-HC mixtures and tablets.

Anahtar Kelimeler

Spectrophotometry, Quantitative determination, Wavelet transform, Irbesartan, Hydrochlorothiazide

BİR ANTİHİPERTANSİF FORMÜLASYONDAKİ AKTİF BİLEŞİKLERİN HAAR-CWT YÖNTEMİYLE SPEKTROFOTOMETRİK TAYİNİ

Öz

Amaç: Bu çalışmada, bir antihipertansif formülasyondaki irbesartan (IR) ve hidroklorotizid (HC) aktif bileşiklerinin miktarlarını aynı anda belirlemek için yeni bir dalgacık yöntemi (HAAR-CWT) geliştirdik ve bu yöntemi doğruladıktan sonra, yukarıda bahsedilen bileşikleri içeren tabletlerin analizine başarıyla uyguladık.

Gereç ve Yöntem: 200-305 nm spektral aralığındaki karışımların ve tablet çözeltilerinin absorpsiyon spektrumları, bir Shimadzu UV-1601 çift ışınlı UV-VIS spektrofotometresi ile ölçülmüştür.

Sonuç ve Tartışma: Bahsedilen bileşenlerin güçlü şekilde örtüşen spektrumları nedeniyle, HAAR-CWT yöntemi önerilmiş ve IR-HC karışımlarının ve tabletlerinin oran spektrumlarına başarıyla uygulanmıştır.      

Anahtar Kelimeler

Spektrofotometri, kantitatif tayin, dalgacık dönüşümü, irbesartan, hidroklorotiyazid

Kaynakça

• 1. Siddiqui M. R., AlOthman Z. A., Rahman N. (2017) Analytical techniques in pharmaceutical analysis: A review. Arabian Journal of Chemistry, 10, 1409-1421.
• 2. Valagaleti R., Burns P.K., Gill M. (2003) Analytical support for drug manufacturing in the United States—from active pharmaceutical ingredient synthesis to drug product shelf life. Drug Inform. J., 37, 407-438.
• 3. Ju H. (2013) Grand challenges in analytical chemistry: towards more bright eyes for scientific research, social events and human health. Front. Chem., https://doi.org/10.3389/fchem.2013.00005.
• 4. Chhonker Y. S., Edi C., Murry D. J. (2018) LC–MS/MS method for simultaneous determination of diethylcarbamazine, albendazole and albendazole metabolites in human plasma: Application to a clinical pharmacokinetic study. J. Pharm. Biomed. Anal., 20-151, 84–90.
• 5. Sáiz J., García-Ruiz C., Gómara B. (2017) Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolites. Analytical Methods, 9, 2897-2908.
• 6. Maurer H. H. (1994) Toxicological analysis of drugs: GC-MS screening and confirmation. Acta Medicinæ Legalis, XLIV, 489-492.
• 7. Rocha F. R. P., Teixeira L. S. G. (2004) Strategies to increase sensitivity in UV-VIS spectrophotometry. Quimica Nova, 27(5), 807-812.
• 8. Thiem T. L. (1994) Comparison of optical-emission mass-spectroscopy utilizing laser vaporization of solid samples for inorganic analysis. American Laboratory, 26(3), 48-52.
• 9. Deyl Z., Janak J., Schwarz V. (2001) Bibliography section - Liquid column chromatography - Gas chromatography - Planar chromatography - Gel chromatography - Capillary electrophoresis and electrokinetic chromatography. Journal Of Chromatography A, 940(2), 119-219.
• 10. Otieno A. C., Mwongela S. M. (2008) Capillary electrophoresis-based methods for the determination of lipids - A review. Analytica Chimica Acta, 624(2), 163-174.
• 11. Naggar A. H., Kotb A., Abdelwahab A.A. (2021) Graphite studded with facile-synthesized cu2o nanoparticle-based cubes as a novel electrochemical sensor for highly sensitive voltametric determination of mebeverine hydrochloride. Chemosensors, https://doi.org/10.3390/chemosensors9020035.
• 12. Daubechies I. (1992) Ten Lectures on Wavelets, Society for Industrial and Applied Mathematics, Philadelphia, 1-357.
• 13. Dinç E., Baleanu D. (2007) Continuous wavelet transform applied to the overlapping absorption signals and their ratio signals for the quantitative resolution of mixture of oxfendazole and oxyclozanide in bolus. J. Food Drug Anal., 15(2), 109-117.
• 14. Üstündağ Ö., Dinç E. (2021) Continuous wavelet transforms and ultra performance liquid chromatography applied to the simultaneous quantitative determination of candesartan cilexetil and hydrochlorothiazide in tablets. Monatshefte für Chemie, https://doi.org/10.1007/s00706-021-02822-7.
• 15. Redasani V. K., Patel P. R., Marathe D.Y., Chaudhari S. R., Shirkhedkar A. A., Surana S. J. (2018) A revıew on derivative uv-spectrophotometry analysis of drugs in pharmaceutical formulations and biological samples review. Journal of the Chilean Chemical Society, http://dx.doi.org/10.4067/s0717-97072018000304126.
• 16. Albero I., Rodenas V., Garcia S., Sanchez C. (2002) Determination of irbesartan in the presence of hydrochlorothiazide by derivative spectrophotometry. J. Pharmaceut. Biomed., 29(1-2), 299-305.
• 17. El-Yazbi A., Hammud H., Sonji M. (2007) Analysis of eprosartan-hydrochlorothiazide and irbesartan -hydrochlorothiazide binary mixtures by derivative spectrophotometry. Int. J. App. Chem., 3(1), 1-12.
• 18. Joseph J., Brault S., Boyer C., Langlois M., Cabrero L., Dubost J. (2003) Simultaneous determination of irbesartan and hydrochlorothiazide in tablets by derivative spectrophotometry. Anal. Lett., 36(11), 2485-2495.
• 19. Kalyani G., Adjuad B. (2019) Stability indicating assay and estimation of irbesartan by first order uv derivative spectrophotometry. International Journal of Pharmaceutical Sciences and Research, 23, 3817-3821.
• 20. Zhu J., You S., Meng X. (2003) Determination of irbesartan and hydrochlorothiazide in compound irbesartan tablets by HPLC. Zhongguo Yiyao Gongye Zazhi, 34(11), 567-569.
• 21. Tutunji L. F., Tutunji M. F., Alzoubi M. I., Khabbas M. H., Arida A. I. (2009) Simultaneous determination of irbesartan and hydrochlorothiazide in human plasma using HPLC coupled with tandem mass spectrometry:Application to bioequivalence studies. J. Pharmaceut. Biomed., 51(4), 985-990.
• 22. Alanazi A. M., Abdelhameed A. S., Khalil N.Y., Khan A. A., Darwish I. A. (2014) HPLC method with monolithic column for simultaneous determination of irbesartan and hydrochlorothiazide in tablets. Acta Pharm., 64, 187-198.
• 23. Nalini C. N., Mathivanan N. (2020) A review on analytical methods of ırbesartan and its combinations in pharmaceutical dosage forms. Current Pharmaceutical Analysis, 16(8), 1020-1029.