SAMBUCUS EBULUS L. BİTKİSİNİN FARKLI KISIMLARININ ANTİOKSİDAN VE ANTİ-ENFLAMATUVAR AKTİVİTELERİ

Yıl 2022, Cilt: 46 Sayı: 3, 728 - 741, 30.09.2022

Büşra Cumhur Sezen Yılmaz Sarıaltın Safa Gümüşok Tülay Çoban Ceyda Sibel Kılıç

https://doi.org/10.33483/jfpau.1115491

Cited By: 1

Öz

Amaç: Adoxaceae (Mürver) ailesinin Sambucus L. cinsi, önceki çalışmalarda antioksidan, anti-enflamatuar, antiviral ve antibakteriyel aktiviteleri nedeniyle araştırılmıştır. Ayrıca, yapraklarda yapılan önceki in vivo ve in vitro çalışmalar, bitkinin anti-enflamatuar aktiviteye sahip olduğunu göstermiştir. Çalışmamız, Sambucus ebulus L. bitkisinin kök, meyve ve yaprak ekstrelerinin in vitro antioksidan ve anti-enflamatuar potansiyelini araştırmayı amaçlamaktadır.
Gereç ve Yöntem: Antioksidan aktivite, Sambucus ebulus kullanılarak biyolojik bir tahlilde değerlendirilirken, radikal süpürücü aktivite 2,2-difenil-1-pikrilhidrazil (DPPH) ve ABTS + yöntemleri kullanılarak ölçülmüştür.
Sonuç ve Tartışma: Maksimum anti-enflamatuvar etki, sırasıyla yaprak ve meyve ekstrelerinin ardından kök ekstrelerinde gözlendi. Kök ekstreleri, anti-enflamatuvar aktivitenin sonuçlarına benzer şekilde en yüksek ABTS ve DPPH serbest radikal süpürme aktivitesini (FRSA) sergiledi. Sonuç olarak, kök ekstresi, FRSA ve antiinflamatuar aktivite açısından diğerleri arasında en güçlü ekstre olmuştur.

Anahtar Kelimeler

Adoxaceae, anti-enflamatuvar aktivite, antioksidan aktivite, cüce mürver, Sambucus ebulus

ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF DIFFERENT PARTS OF SAMBUCUS EBULUS L.

Öz

Objective: Sambucus L. genus of Adoxaceae (Elderberry) family was investigated in previous studies for its antioxidant, anti-inflammatory, antiviral and antibacterial activities. Moreover, previous in vivo and in vitro studies performed on the leaves showed that the plant possesses anti-inflammatory activity. Our study aims to investigate the in vitro antioxidant and anti-inflammatory potential of the stem, fruit and leaf extracts of Sambucus ebulus L. plant.
Material and Method: The antioxidant activity was evaluated in a biological assay using Sambucus ebulus, whereas the radical scavenging activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ABTS methods.
Result and Discussion: The maximum anti-inflammatory effect was observed in stem extracts followed by leaf and fruit extracts, respectively. Stem extracts exhibited the highest ABTS and DPPH free radical scavenging activity (FRSA) similar to the results of anti-inflammatory activity. As a conclusion, stem extracts were the most potent extracts among the others regarding the FRSA and anti-inflammatory activities.In our study, the biological activity potential of the extracts was demonstrated, thus providing data supporting the traditional use of Sambucus ebulus L.

Anahtar Kelimeler

Adoxaceae, anti-inflammatory activity, antioxidant activity, dwarf elder, Sambucus ebulus

Kaynakça

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