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LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER

Yıl 2024, Cilt: 48 Sayı: 1, 274 - 288, 20.01.2024
https://doi.org/10.33483/jfpau.1348607

Öz

Amaç: Meme kanseri dünya genelinde kadınlarda en sık gözlenen kanser türü olup, erken teşhis ve etkili tedavi stratejilerinin geliştirilmesi için sürekli araştırmaların yapılmasını gerektiren kritik bir sağlık sorunudur. Geleneksel kemoterapi uygulamalarındaki spesifik olmayan hedefleme, sistemik toksisite, ilaç direnci, kısıtlı ilaç penetrasyonu gibi sınırlamaların aşılmasında yenilikçi tedavi yöntemlerinin geliştirilmesine ihtiyaç duyulmaktadır. İlaç taşıyıcı sistemler olarak enjektabl hidrojeller biyoparçalanır, biyouyumlu, tasarıma yönelik ayarlanabilir fizikokimyasal özelliklerinin yanı sıra etkin maddenin yüksek verimlilikte yüklenmesini ve salımını sağlayabilmesi dolayısıyla lokal kanser tedavilerinde ön plana çıkmaktadır. Enjektabl biyoparçalanır hidrojeller özellikle cerrahi sonrası tedavi sürecinde tümör nüksünü ve metastazını önlemede kritik öneme sahiptir. Bu derlemede enjektabl hidrojellerin yapıları, türleri, kanser tedavilerine ilişkin uygulamaları ve antikanser tedavi etkinliklerinin değerlendirilmesi amaçlanmıştır.
Sonuç ve Tartışma: Bu derlemede farmasötik ilaç taşıyıcı sistemler olarak enjektabl hidrojel yapıları, meme kanseri tedavilerine ilişkin uygulamaları ve meme kanserine yönelik antikanser tedavi etkinlikleri ele alınmıştır.

Kaynakça

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EFFECTIVE DRUG DELIVERY SYSTEMS IN LOCALIZED BREAST CANCER THERAPIES: INJECTABLE HYDROGELS

Yıl 2024, Cilt: 48 Sayı: 1, 274 - 288, 20.01.2024
https://doi.org/10.33483/jfpau.1348607

Öz

Objective: Breast cancer is the most common cancer in women worldwide and is a critical health problem that requires continuous research for early detection and development of effective treatment strategies. There is a need to develop innovative treatment modalities to overcome the limitations of conventional chemotherapy such as non-specific targeting, systemic toxicity, drug resistance and limited drug penetration. As drug delivery systems, injectable hydrogels have come to the forefront in local cancer treatments due to their biodegradable, biocompatible, design-adjustable physicochemical properties as well as their ability to provide highly efficient loading and release of the active substance. Injectable biodegradable hydrogels are critical in preventing cancer
recurrence and metastasis, especially in the post surgical treatment process. In this review, we aimed to evaluate the structures, types, cancer treatment applications and anticancer therapeutic efficacy of injectable hydrogels.
Result and Discussion: In this review, the structures of injectable hydrogels as pharmaceutical drug delivery systems, their applications in breast cancer treatments and their anticancer therapeutic efficacy for breast cancer were discussed.

Kaynakça

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  • 82. Sharma, P.K., Singh, Y. (2019). Glyoxylic hydrazone linkage-based PEG hydrogels for covalent entrapment and controlled delivery of doxorubicin. Biomacromolecules, 20(6), 2174-2184. [CrossRef]
  • 83. Li, L., Scheiger, J.M., Levkin, P.A. (2019). Design and applications of photoresponsive hydrogels. Advanced Materials, 31(26), 1807333. [CrossRef]
  • 84. Bustamante-Torres, M., Romero-Fierro, D., Arcentales-Vera, B., Palomino, K., Magaña, H., Bucio, E. (2021). Hydrogels classification according to the physical or chemical interactions and as stimuli-sensitive materials. Gels, 7(4), 182. [CrossRef]
  • 85. Ji, W., Wu, Q., Han, X., Zhang, W., Wei, W., Chen, L., Li, L., Huang, W. (2020). Photosensitive hydrogels: From structure, mechanisms, design to bioapplications. Science China Life Sciences, 63, 1813-1828. [CrossRef]
  • 86. Peng, K., Zheng, L., Zhou, T., Zhang, C., Li, H. (2022). Light manipulation for fabrication of hydrogels and their biological applications. Acta Biomaterialia, 137, 20-43. [CrossRef]
  • 87. Phan, L.M.T., Vo, T.A.T., Hoang, T.X., Cho, S. (2021). Graphene integrated hydrogels based biomaterials in photothermal biomedicine. Nanomaterials, 11(4), 906. [CrossRef]
  • 88. Mi, D., Li, J., Wang, R., Li, Y., Zou, L., Sun, C., Yan, S., Yang, H., Zhao, M., Shi, S. (2023). Postsurgical wound management and prevention of triple-negative breast cancer recurrence with a pryoptosis-inducing, photopolymerizable hydrogel. Journal of Controlled Release, 356, 205-218. [CrossRef]
  • 89. Kuppusamy, P., Li, H., Ilangovan, G., Cardounel, A.J., Zweier, J.L., Yamada, K., Krishna, M.C., Mitchell, J.B. (2002). Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels. Cancer Research, 62(1), 307-312.
  • 90. Quinn, J.F., Whittaker, M.R., Davis, T.P. (2017). Glutathione responsive polymers and their application in drug delivery systems. Polymer Chemistry, 8(1), 97-126. [CrossRef]
  • 91. Ye, H., Zhou, Y., Liu, X., Chen, Y., Duan, S., Zhu, R., Liu, Y., Yin, L. (2019). Recent advances on reactive oxygen species-responsive delivery and diagnosis system. Biomacromolecules, 20(7), 2441-2463. [CrossRef]
  • 92. Degirmenci, A., Ipek, H., Sanyal, R., Sanyal, A. (2022). Cyclodextrin-containing redox-responsive nanogels: Fabrication of a modular targeted drug delivery system. European Polymer Journal, 181, 111645. [CrossRef]
  • 93. Kasiński, A., Zielińska-Pisklak, M., Oledzka, E., Sobczak, M. (2020). Smart hydrogels-synthetic stimuli-responsive antitumor drug release systems. International Journal of Nanomedicine, 4541-4572. [CrossRef]
  • 94. Gerami, S.E., Pourmadadi, M., Fatoorehchi, H., Yazdian, F., Rashedi, H., Nigjeh, M.N. (2021). Preparation of pH-sensitive chitosan/polyvinylpyrrolidone/α-Fe2O3 nanocomposite for drug delivery application: Emphasis on ameliorating restrictions. International Journal of Biological Macromolecules, 173, 409-420. [CrossRef]
  • 95. Mahdi Eshaghi, M., Pourmadadi, M., Rahdar, A., Díez-Pascual, A.M. (2022). Novel carboxymethyl cellulose-based hydrogel with core-shell Fe3O4@ SiO2 nanoparticles for quercetin delivery. Materials, 15(24), 8711. [CrossRef]
  • 96. Barani, M., Rahdar, A., Mukhtar, M., Razzaq, S., Qindeel, M., Olam, S.A.H., Paiva-Santos, A.C., Ajalli, N., Sargazi, S., Balakrishnan, D. (2022). Recent application of cobalt ferrite nanoparticles as a theranostic agent. Materials Today Chemistry, 26, 101131. [CrossRef]
  • 97. Veloso, S.R., Magalhães, C.A., Rodrigues, A.R.O., Vilaça, H., Queiroz, M.J.R., Martins, J., Coutinho, P.J., Ferreira, P.M., Castanheira, E.M. (2019). Novel dehydropeptide-based magnetogels containing manganese ferrite nanoparticles as antitumor drug nanocarriers. Physical Chemistry Chemical Physics, 21(20), 10377-10390. [CrossRef]
  • 98. Veloso, S.R., Ferreira, P.M., Martins, J.A., Coutinho, P.J., Castanheira, E.M. (2018). Magnetogels: Prospects and main challenges in biomedical applications. Pharmaceutics, 10(3), 145. [CrossRef]
  • 99. Li, D.Q., Wang, S.Y., Meng, Y.J., Li, J.F., Li, J. (2020). An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3. International Journal of Biological Macromolecules, 164, 4566-4574. [CrossRef]
  • 100. Gao, F., Xie, W., Miao, Y., Wang, D., Guo, Z., Ghosal, A., Li, Y., Wei, Y., Feng, S.S., Zhao, L. (2019). Magnetic hydrogel with optimally adaptive functions for breast cancer recurrence prevention. Advanced Healthcare Materials, 8(14), 1900203. [CrossRef]
  • 101. Versaw, B.A., Zeng, T., Hu, X., Robb, M.J. (2021). Harnessing the power of force: Development of mechanophores for molecular release. Journal of the American Chemical Society, 143(51), 21461-21473. [CrossRef]
  • 102. Kim, G., Lau, V.M., Halmes, A.J., Oelze, M.L., Moore, J.S., Li, K.C. (2019). High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers. Proceedings of the National Academy of Sciences, 116(21), 10214-10222. [CrossRef]
  • 103. Kim, G., Wu, Q., Chu, J.L., Smith, E.J., Oelze, M.L., Moore, J.S., Li, K.C. (2022). Ultrasound controlled mechanophore activation in hydrogels for cancer therapy. Proceedings of the National Academy of Sciences, 119(4), e2109791119. [CrossRef]
  • 104. Jo, Y.J., Gulfam, M., Jo, S.H., Gal, Y.S., Oh, C.W., Park, S.H., Lim, K.T. (2022). Multi-stimuli responsive hydrogels derived from hyaluronic acid for cancer therapy application. Carbohydrate Polymers, 286, 119303. [CrossRef]
  • 105. Zhao, L., Xu, J., Tong, Y., Gong, P., Gao, F., Li, H., Jiang, Y. (2022). Injectable “cocktail” hydrogel with dual‐stimuli‐responsive drug release, photothermal ablation, and drug‐antibody synergistic effect. SmartMat, 1-11 (Early view). [CrossRef]
  • 106. Zhu, Y., Wang, L., Li, Y., Huang, Z., Luo, S., He, Y., Han, H., Raza, F., Wu, J., Ge, L. (2020). Injectable pH and redox dual responsive hydrogels based on self-assembled peptides for anti-tumor drug delivery. Biomaterials Science, 8(19), 5415-5426. [CrossRef]
Toplam 106 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular İlaç Dağıtım Teknolojileri
Bölüm Derleme
Yazarlar

Süheyl Furkan Konca 0000-0001-8179-5930

Umut Can Öz 0000-0001-5225-748X

Asuman Bozkır 0000-0002-2782-3280

Erken Görünüm Tarihi 12 Ekim 2023
Yayımlanma Tarihi 20 Ocak 2024
Gönderilme Tarihi 23 Ağustos 2023
Kabul Tarihi 21 Eylül 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 48 Sayı: 1

Kaynak Göster

APA Konca, S. F., Öz, U. C., & Bozkır, A. (2024). LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER. Journal of Faculty of Pharmacy of Ankara University, 48(1), 274-288. https://doi.org/10.33483/jfpau.1348607
AMA Konca SF, Öz UC, Bozkır A. LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER. Ankara Ecz. Fak. Derg. Ocak 2024;48(1):274-288. doi:10.33483/jfpau.1348607
Chicago Konca, Süheyl Furkan, Umut Can Öz, ve Asuman Bozkır. “LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER”. Journal of Faculty of Pharmacy of Ankara University 48, sy. 1 (Ocak 2024): 274-88. https://doi.org/10.33483/jfpau.1348607.
EndNote Konca SF, Öz UC, Bozkır A (01 Ocak 2024) LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER. Journal of Faculty of Pharmacy of Ankara University 48 1 274–288.
IEEE S. F. Konca, U. C. Öz, ve A. Bozkır, “LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER”, Ankara Ecz. Fak. Derg., c. 48, sy. 1, ss. 274–288, 2024, doi: 10.33483/jfpau.1348607.
ISNAD Konca, Süheyl Furkan vd. “LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER”. Journal of Faculty of Pharmacy of Ankara University 48/1 (Ocak 2024), 274-288. https://doi.org/10.33483/jfpau.1348607.
JAMA Konca SF, Öz UC, Bozkır A. LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER. Ankara Ecz. Fak. Derg. 2024;48:274–288.
MLA Konca, Süheyl Furkan vd. “LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER”. Journal of Faculty of Pharmacy of Ankara University, c. 48, sy. 1, 2024, ss. 274-88, doi:10.33483/jfpau.1348607.
Vancouver Konca SF, Öz UC, Bozkır A. LOKALİZE MEME KANSERİ TEDAVİLERİNDE EFEKTİF İLAÇ TAŞIYICI SİSTEMLER: ENJEKTABL HİDROJELLER. Ankara Ecz. Fak. Derg. 2024;48(1):274-88.

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.