MUCOADHESIVE POLYMERS IN COLON TARGETED DRUG DELIVERY SYSTEMS: A COMPREHENSIVE REVIEW

Yıl 2024, Cilt: 48 Sayı: 2, 696 - 713, 20.05.2024

Aylin Deljavan Ghodratı , Tansel Çomoğlu

https://doi.org/10.33483/jfpau.1400920

Öz

Objective: Mucoadhesive polymers have emerged as crucial components in the realm of drug delivery systems, particularly in the context of targeted treatments within the colon. These polymers possess adhesive properties that enable them to form temporary bonds with mucosal surfaces, extending the contact time of drugs with the colonic mucosa. This review provides a comprehensive overview of mucoadhesive polymers for colon drug delivery systems. Natural polymers such as chitosan and alginate, along with synthetic counterparts like polyacrylic acid derivatives, find application in these systems. The advantages of mucoadhesive polymers lie in their ability to facilitate site-specific drug delivery, thereby minimizing systemic side effects, and in enabling controlled and sustained release of drugs for improved bioavailability. Despite these benefits, challenges including variability in mucosal conditions and the imperative need for biocompatibility must be addressed. The applications of mucoadhesive polymers span diverse medical conditions, including targeted delivery of anti-inflammatory drugs for inflammatory bowel diseases, localized administration of chemotherapeutic agents for colon cancer treatment, and precise delivery of antibiotics for colonic infections.
Result and Discussion: As a promising avenue for optimizing colon drug delivery, mucoadhesive polymers offer great potential for the development of effective and well-tolerated treatments for various colonic disorders.

Anahtar Kelimeler

Colon, colon drug delivery systems, mucosa, mucoadhesion, mucoadhesive polymers

MUKOADEZİF POLİMERLERİN KOLON HEDEFLİ İLAÇ TAŞIYICI SİSTEMLERDE KULLANIMI: DETAYLI BİR İNCELEME

Öz

Amaç: Mukoadezif polimerler, özellikle kolon bölgesinde hedefe yönelik tedaviler bağlamında, ilaç taşıyıcı sistemler alanında çok önemli bileşenler olarak ortaya çıkmıştır. Bu polimerler, mukozal yüzeylerle geçici bağlar oluşturmalarını sağlayan ve ilaçların kolon mukozası ile temas süresini uzatan yapışkan özelliklere sahiptir. Bu derleme, kolon ilaç taşıyıcı sistemleri için mukoadezif polimerlere kapsamlı bir genel bakış sunmaktadır. Kitosan ve aljinat gibi doğal polimerlerin yanı sıra poliakrilik asit türevleri gibi sentetik muadilleri de bu sistemlerde uygulama alanı bulmaktadır. Mukoadhezif polimerlerin avantajları, bölgeye özgü ilaç dağıtımını kolaylaştırma, böylece sistemik yan etkileri en aza indirme ve gelişmiş biyoyararlanım için ilaçların kontrollü ve sürekli salınımını sağlama yeteneklerinde yatmaktadır. Bu avantajlara rağmen, mukozal koşullardaki değişkenlik ve biyouyumluluk için zorunlu ihtiyaç gibi zorluklar ele alınmalıdır. Mukoadezif polimerlerin uygulamaları, enflamatuar bağırsak hastalıkları için anti-enflamatuar ilaçların hedefe yönelik olarak verilmesi, kolon kanseri tedavisi için kemoterapötik ajanların lokalize olarak verilmesi ve kolon enfeksiyonları için antibiyotiklerin hassas bir şekilde verilmesi dahil olmak üzere çeşitli tıbbi koşulları kapsamaktadır.
Sonuç ve Tartışma: Kolon ilaç dağıtımını optimize etmek için umut verici bir yol olan mukoadezif polimerler, çeşitli kolonik hastalıklar için etkili ve iyi tolere edilen tedavilerin geliştirilmesi için büyük bir potansiyel sunmaktadır.

Anahtar Kelimeler

Kolon, kolon ilaç taşıyıcı sistemler, mukoza, mukoadhezyon, mukoadhezif polimerler

Kaynakça

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