Fetal malnütrisyonlu term bebeklerde ilk iki yaştaki büyüme, glukoz, insülin ve lipid profili

Öz

Amaç: Fetal dönemde büyüme kısıtlılığı, ileri yaşlarda metabolik hastalıkların gelişimini etkileyebilir. Bu çalışmada, fetal malnütrisyonu olan ve olmayan term yenidoğan bebeklerin ilk iki yaştaki büyümelerinin ve ikinci yaştaki glukoz, insülin ve lipid profillerinin karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya Mayıs 2019 ile Ekim 2019 tarihleri arasında hastanemizde doğan, CANSCORE yöntemi kullanılarak fetal malnütrisyon saptanan ve saptanmayan term bebekler alındı. Umblikal kord kanında insülin, glukoz, total kolesterol, LDL kolesterol, HDL kolesterol, VLDL kolesterol, trigliserid değerlerine bakıldı. Bu bebeklerin iki yaşına kadar büyümeleri takip edildi. İkinci yıl sonunda aynı paramtrelere yeniden bakıldı. Bulgular: Fetal malnutrisyon saptanan 40 bebekten 26’sı, fetal malnutrisyon saptanmayan 40 bebekten 22’si iki yıl boyunca takip edildi. Fetal malnütrisyonu olan bebeklerin 6. ayında vücut ağırlığı, boy uzunluğu ve baş çevresinin, fetal malnütrisyonlu olmayan bebeklere göre daha yüksek olduğu ancak 12 ve 24. ayda bu farkın gerilediği görüldü. Yaşamının ikinci yılında bakılan glikoz, insülin, total kolesterol, LDL kolesterol, HDL kolesterol düzeyleri arasında her iki grup arasında anlamlı farklılık yokken, VLDL kolesterol ve trigliserid düzeyleri fetal malnütrisyonu olan grupta anlamlı olarak daha yüksek saptandı. Sonuç: Fetal malnütrisyonlu bebeklerde yaşamının ilk 6 ayındaki hızlı kilo artışı erken çocukluk dönemindeki lipid profilini etkileyebilir.

Anahtar Kelimeler

• Fetal malnütrisyon
• Büyüme
• Kolesterol
• Trigliserid

Growth, glucose, insulin and lipid profile in the first two years of term infants with fetal malnutrition

Öz

Aim: Growth restriction in the fetal period may affect the development of metabolic diseases in later ages. In this study, it was aimed to compare the growth of the first two years of age and the glucose, insulin and lipid profiles in the second year of term newborn babies with and without fetal malnutrition. Materials and Methods: Term infants born in our hospital between May 2019 and October 2019, with and without fetal malnutrition detected using the CANSCORE method were included in the study. Insulin, glucose, total cholesterol, LDL cholesterol, HDL cholesterol, VLDL cholesterol and triglyceride values were measured in the umbilical cord blood. The growth of these babies was followed up to the age of two. At the end of the second year, the same parameters were looked at again. Results: 26 out of 40 babies with fetal malnutrition and 22 out of 40 babies without fetal malnutrition were followed for two years. It was observed that body weight, height and head circumference of babies with fetal malnutrition were higher at 6 months compared to babies without fetal malnutrition, but this difference regressed at 12 and 24 months. While there was no significant difference between the two groups in terms of glucose, insulin, total cholesterol, LDL cholesterol, and HDL cholesterol levels in the second year of life, VLDL cholesterol and triglyceride levels were found to be significantly higher in the group with fetal malnutrition. Conclusion: Rapid weight gain in the first 6 months of life in infants with fetal malnutrition may affect the lipid profile in early childhood.

Anahtar Kelimeler

• Fetal malnutrition
• Growth
• Cholesterol
• Triglyceride

Kaynakça

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