Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma?

Neslihan Bayramoğlu Tepe; Özcan Balat; Tanyeli Güneyligil; Hüseyin Ozcan; Seyhun Sucu; Özge Kömürcü Karuserci; Mete Gürol Uğur; Hilmi Taşdemir

Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma?

Öz

Amaç: Endometrioma hastalarında serum 25-OH vitamin D ve 8-Hidroksi 2-deoksigunazin (8-OH2dG) seviyelerini karşılaştırmak, kist boyutu ile ilişkisini saptamak. Gereç ve Yöntemler: Çalışmaya endometrioma tanısı alan 54 hasta ile normal over dokusuna sahip 26 hasta kontrol grubu olarak dahil edildi. Serum örneklerinde 25-OH vitamin D ve 8-OH2dG seviyelerine bakıldı. Bulgular: Hasta ve kontrol grubu arasında yaş, gebelik, doğum sayısı ve vücut kitle indexi (VKI) bakımından farklılık yoktu. Hasta grubunun D vitamini düzeyi, kontrol grubuna göre anlamlı derecede düşüktü (p=0.001). Kisti bilateral olan hastalar ile, kisti unilateral olan hastalar arasında D vitamini düzeyleri bakımından anlamlı farklılık yoktu (p=0.39). Hasta grubunda 48 (%88.8), kontrol grubunda 11 (%42.3) hastada D vitamini seviyesi <30-microgr/L idi. Hasta grubunda, D vitamini düzeyi hipovitaminoz seviyede olan hastalarda ortalama endometrioma çapı 58,4±25,14 mm iken, D vitamini düzeyi normal saptanan hastalarda endometrioma çapı ise 35,33±18,26 mm idi. Hipovitaminoz D saptanan hastalarda kist çapı ile D vitamini düzeyleri arasında ters bir ilişki saptandı. İki grup arasında 8-OH2dG düzeyleri bakımından anlamlı farklılık yoktu (p>0.05). Sonuç: Endometrioma varlığı, kist çapı ve serum D vitamini düzeyleri arasında ters ilişki olmasına rağmen, serum 8-OH2dG düzeylerinde değişiklik yoktu. Bu durum, overyan endometriozisin patogenezinde hala belirsiz noktalar olduğunu göstermektedir.

Anahtar Kelimeler

Endometrioma,25-OH vitamin D

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Kadın Hastalıkları ve Doğum

Bölüm

Araştırma Makalesi

Yazarlar

Neslihan Bayramoğlu Tepe ^*
0000-0003-0396-5791
Türkiye

Özcan Balat
0000-0002-9158-0009
Türkiye

Tanyeli Güneyligil
0000-0002-4191-1244
Türkiye

Hüseyin Ozcan
0000-0002-4922-7148
Türkiye

Seyhun Sucu
0000-0001-6821-4070
Türkiye

Özge Kömürcü Karuserci
0000-0003-3836-2958
Türkiye

Mete Gürol Uğur
0000-0002-0720-970X
Türkiye

Hilmi Taşdemir
0000-0002-7820-6290
Türkiye

Yayımlanma Tarihi

31 Aralık 2019

Gönderilme Tarihi

27 Aralık 2019

Kabul Tarihi

29 Aralık 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 16 Sayı: 4

IZ

https://izlik.org/JA85PP99XM

Kaynak Göster

RIS / Bibtex

APA

Bayramoğlu Tepe, N., Balat, Ö., Güneyligil, T., Ozcan, H., Sucu, S., Kömürcü Karuserci, Ö., Uğur, M. G., & Taşdemir, H. (2019). Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma? Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 16(4), 191-195. https://izlik.org/JA85PP99XM

AMA

1.Bayramoğlu Tepe N, Balat Ö, Güneyligil T, vd. Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma? JGON. 2019;16(4):191-195. https://izlik.org/JA85PP99XM

Chicago

Bayramoğlu Tepe, Neslihan, Özcan Balat, Tanyeli Güneyligil, vd. 2019. “Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma?”. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 16 (4): 191-95. https://izlik.org/JA85PP99XM.

EndNote

Bayramoğlu Tepe N, Balat Ö, Güneyligil T, Ozcan H, Sucu S, Kömürcü Karuserci Ö, Uğur MG, Taşdemir H (01 Aralık 2019) Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma? Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 16 4 191–195.

IEEE

[1]N. Bayramoğlu Tepe vd., “Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma?”, JGON, c. 16, sy 4, ss. 191–195, Ara. 2019, [çevrimiçi]. Erişim adresi: https://izlik.org/JA85PP99XM

ISNAD

Bayramoğlu Tepe, Neslihan - Balat, Özcan - Güneyligil, Tanyeli - Ozcan, Hüseyin - Sucu, Seyhun - Kömürcü Karuserci, Özge - Uğur, Mete Gürol - Taşdemir, Hilmi. “Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma?”. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 16/4 (01 Aralık 2019): 191-195. https://izlik.org/JA85PP99XM.

JAMA

1.Bayramoğlu Tepe N, Balat Ö, Güneyligil T, Ozcan H, Sucu S, Kömürcü Karuserci Ö, Uğur MG, Taşdemir H. Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma? JGON. 2019;16:191–195.

MLA

Bayramoğlu Tepe, Neslihan, vd. “Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma?”. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, c. 16, sy 4, Aralık 2019, ss. 191-5, https://izlik.org/JA85PP99XM.

Vancouver

1.Neslihan Bayramoğlu Tepe, Özcan Balat, Tanyeli Güneyligil, Hüseyin Ozcan, Seyhun Sucu, Özge Kömürcü Karuserci, Mete Gürol Uğur, Hilmi Taşdemir. Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma? JGON [Internet]. 01 Aralık 2019;16(4):191-5. Erişim adresi: https://izlik.org/JA85PP99XM