Öz

Aim: To evaluate the roles of increased levels of fibronectin in vaginal fluid for prediction of preterm delivery Methods: Fibronectin levels of cervicovaginal fluid were measured in 73 consecutive pregnant women aged 24-34 weeks of gestation. It was analyzed whether the level of fibronectin had predictive properties for preterm delivery. Results: Of the 73 pregnant women, 19 delivered preterm (26%) and 54 delivered at term (74%). For predicting preterm birth, cut-off values were determined using ROC (Receive Operating Characteristic Curve) curves and corresponding values. Cut-off value of fibronectin was determined to be 61.5 ng / mL and the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 100%, 92.6%, 82.6% and 100% , respectively. Conclusion: The study support the fibronectin in vaginal fluid can be used for predict of preterm delivery in pregnant women at 24-34 weeks of gestation.

Anahtar Kelimeler

• preterm birth,pregnancy,fibronectin

Cervico-Vaginal Fibronectin in Prediction of Preterm Delivery

Öz

Amaç: Preterm doğumun öngörüsünde vajinal sıvıdaki artmış fibronektin düzeylerinin rolünü değerlendirmek Gereç ve Yöntem: Servikovajinal yıkama sıvısında fibronektin düzeyleri 24-34. haftalar arasında olan 73 ardışık gebede ölçüldü. Fibronektin düzeyinin preterm doğum için prediktif özelliklere sahip olup olmadığı analiz edildi. Bulgular: 73 gebe kadından 19'u (% 26) preterm ve 54'ü (% 74) miadında doğum yaptı. Erken doğumu öngörmede için, cutt-off değerleri ROC (Receive Operating Characteristic Curve) eğrileri ve karşılık gelen değerler kullanılarak belirlendi. Fibronektin için cut-off değeri 61.5 ng / mL olarak belirlendi ve duyarlılık, özgüllük, pozitif kestirim değeri (PPV) ve negatif kestirim değeri (NPV) sırasıyla% 100,% 92,6,% 82,6 ve% 100 idi. Sonuç: 24-34. haftalardaki gebe kadınlarda serviko-vajinal sıvıdaki fibronektin, preterm doğumu öngörmede kullanılabilir.

Anahtar Kelimeler

• erken doğum,fibronektin,gebelik

Kaynakça

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