A Crosssectional Study Of 25 Hydroxy Vitamin D And Parathroid Hormone Status During Pregnancy In Ankara Turkey

Öz

Aim: Vitamin D deficiency is common during pregnancy. We aimed to assess the incidence of vitamin D deficiency and vitamin supplementation rates during pregnancy in a relatively large cohort of pregnant Turkish women.Material and Methods: Pregnant women who admitted to the antenatal follow-up clinic between June and December 2013 fulfilled a survey which includes information about eating habits, lifestyleand vitamin supplementation. Blood samples were obtained to measure vitamin D and Parathyroid hormone levels from the pregnant who gave a written consent.Results: A total of 1088 pregnant women were analyzed. Mean vitamin D concentration was 17.5±9.9 ng/mL and PTH was 18.7±11.4 pg/ ml. Vitamin D deficiency < 20 ng/ml was observed in 693 63.6 % women. Five 0.45% women received vitamin D supplementation alone, 71 6.5 % received multivitamins. Multi-nominal logistic regression analysis revealed that, summer season OR: 92.7, 95% CI 36.4-236; p

Anahtar Kelimeler

• Vitamin D deficiency,pregnancy,Turkey

Ankara İlinde Gebelerde 25-Hidroksi Vitamin D ve Paratiroid Hormon Düzeylerinin Kesitsel İncelemesi

Öz

Amaç: Vitamin D eksikliği gebelikte sık görülür. Çalışmamızda geniş bir Türk gebe kohortu değerlendirildi, gebelik süresince D vitamini eksikliği insidansı ve vitamin desteği alma oranlarının saptanması amaçlandı.Gereç ve Yöntemler: Haziran - Aralık 2013 tarihleri arasında hastanemiz gebelik izlem poliklinliğine başvuran ve gönüllü olan gebeler ile , yeme alışkanlıkları, yaşam tarzları ve vitamin takviyesi ile ilgili soruların yer aldığı bir anket gerçekleştirdi. Yazılı onamı alınan gebelerden D vitamini ve Paratiroid hormon düzeylerini ölçmek için kan örnekleri alındı.Bulgular: Toplam 1088 gebe analiz edildi. Ortalama D vitamini düzeyi 17.5 ± 9.9 ng / mL ve PTH 18.7 ± 11.4 pg / ml idi. Vitamin D eksikliği

Anahtar Kelimeler

• Vitamin D eksikliği,gebelik,Türkiye

Kaynakça

1. Holick MF. Vitamin D: evolutionary, physiological and health perspecti- ves. Curr Drug Targets2011; 12: 4-18.
2. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96:1911–30.
3. Xiao JP, Zang J, Pei JJ, Xu F, Zhu Y, Liao XP. Low maternal vitamin D sta- tus during the second trimester of pregnancy: a cross-sectional study in Wuxi, China. PLoS One 2015 6;10(2):e0117748.
4. Gür EB, Turan GA, Tatar S, Gökduman A, Karadeniz M, Celik G, et al. Theeffect of place of residenceandlifestyle on vitamin D deficiency in pregnancy: Comparison of easternand western parts of Turkey. J Turk GerGynecolAssoc 2014;15:149-55.
5. Gür G, Abaci A, Köksoy AY, Anik A, Catli G, Kişlal FM, et al. Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a prelimi- narystudy. Turk J Med Sci 2014; 44: 616-23.
6. https://www.saglik.gov.tr/TR,11158/gebelere-d-vitamini-destek-progra- mi.html
7. Marshall I, Mehta R, Petrova A. Vitamin D in the maternal–fetal–neonatal interface: Clinical implications and requirements for supplementation. J Matern Fetal Neonatal Med 2013;26:633–8
8. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011;26:2341–57

9. Song SJ, Zhou L, Si S, et al. The high prevalence of vitamin D deficiency and its related maternal factors in pregnant women in Beijing. PLoS One 2013;8: e85081.
10. Shibata M, Suzuki A, Sekiya T, et al. High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner Metab 2011;29:615–20
11. Milman N, Hvas AM, Bergholt T. Vitamin D status during normal preg- nancy and postpartum. A longitudinal study in 141 Danish women. J Perinat Med 2011;40:57–61 .
12. Özdemir AA, Ercan Gündemir Y, Küçük M, Yıldıran Sarıcı D, Elgörmüş Y, Çağ Y, Bilek G.Vitamin D Deficiency in Pregnant Women and Their Infants.J Clin Res Pediatr Endocrinol 2018 Mar 1;10(1):44-50. doi: 10.4274/jcrpe.4706
13. Kılıcaslan AÖ, Kutlu R, Kilinc I, Ozberk DI.The effects of vitamin D supp- lementation during pregnancy and maternal vitamin D levels on neonatal vitamin D levels and birth parameters.J Matern Fetal Neonatal Med 2018 Jul;31(13):1727-1734
14. Gür G, Abaci A, Köksoy AY, Anik A, Catli G, Kişlal FM, Akin KO, Andiran N.Incidence of maternal vitamin D deficiency in a region of Ankara, Tur- key: a preliminary study.Turk J Med Sci 2014;44(4):616-23.
15. Aydogmus S, Kelekci S, Aydogmus H, Eriş S, Desdicioğlu R, Yilmaz B, Sağlam G.High prevalence of vitamin D deficiency among pregnant wo- men in a Turkish population and impact on perinatal outcomes.J Matern Fetal Neonatal Med 2015;28(15):1828-32
16. Parlak M, Kalay S, Kalay Z, Kirecci A, Guney O, Koklu E.Severe vitamin D deficiency among pregnant women and their newborns in Turkey.J Matern Fetal Neonatal Med 2015 Mar;28(5):548-51
17. van der Pligt P, Willcox J, Szymlek-Gay EA, Murray E, Worsley A, Daly RM.Associations of Maternal Vitamin D Deficiency with Pregnancy and Neonatal Complications in Developing Countries: A Systematic Review. Nutrients 2018 May 18;10(5). pii: E640. doi: 10.3390/nu10050640
18. http://www.who.int/elena/titles/vitamind_supp_pregnancy/en/
19. ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy. Obstet Gynecol 2011 Jul;118(1):197-8. doi: 10.1097/AOG.0b013e318227f06b.
20. Canadian Pediatric Society. Vitamin D supplementation: Recommenda- tions for Canadian mothers and infants. J Paediatr Child Health 2007;12: 583–598.