Cleavage-Stage Or Blastocyst Transfer: Does İt Affect Pregnancy And Live Birth Rate İn Frozen-Thawed Embryo Transfer Cycle?

Öz

Aim: Despite the existence of conflicting data regarding success and safety, there has been an increasing trend to frozen embryo cycle and blastocyst transfer worldwide. The aim of this study is to evaluate clinical results and pregnancy outcomes of frozen-thawed embryo transfer with cleavage stage versus blastocyst stage.Material and Methods: In this retrospective study, we evaluated 102 frozen embryo transfer FET cycles of single IVF center between 2014 and 2017. A total of 52 frozen-thawed cleavage stage embryo transfer cycles C-FET were compared with 50 FET cycles with blastocyst B-FET .Results: There was no difference in age, infertility reason, type of preceding ovulation induction protocol, cumulative dose of gonadotropin, number of retrieved oocyte and mean number of transferred embryo between the C-FET group and B-FET group. Clinical pregnancy and live birth rates were higher but not significant in B-FET group 50% and 22.5% than C-FET group 28% and 16.7% Conclusion: This study showed that, results of blastocyst transfer in frozen embryo transfer cycle were more favorable but there was no significant difference between the two groups in terms of clinical pregnancy and live birth rates. A further large-scale prospective study is needed.

Anahtar Kelimeler

• Cryopreserved embryo,blastocyst-cleavage transfer,pregnancy outcome

Dondurulmuş Embriyo Siklusunda Embriyo Transfer Zamanlaması Gebelik Başarısını Etkiler Mi? Tek Merkez Deneyimi

Öz

Amaç: Dondurulmuş çözülmüş embriyo ve blastokist transferinin güvenilirliği ve klinik başarısı ile ilgili çelişkili yayınlara rağmen, tüm dünyada dondurulmuş embriyo ve blastokist transferi yönünde bir eğilim mevcuttur. Bu çalışmanın amacı dondurulmuş embriyo siklusunda klivaj ve blastokist evresi embriyo transferlerinin klinik ve gebelik sonuçlarını karşılaştırmaktır.Gereç ve Yöntemler: Bu retrospektif çalışmada, tek bir merkezde 2014 ile 2017 tarihleri arasında gerçekleştirilen 102 dondurulmuş çözülmüş embriyo transfer DÇET siklusunun sonuçları incelendi ve bu dönemde yapılan 52 klivaj evresi dondurulmuş çözülmüş embriyo transfer K-DÇET siklusu ile 50 blastokist evresi dondurulmuş çözülmüş embriyo transfer B-DÇET siklusunun klinik ve canlı doğum sonuçları karşılaştırıldı.Bulgular: K-DÇET ve B-DÇET gruplarındaki hastaların yaşı, infertilite nedenleri, önceden uygulanan ovulasyon indüksyon protokolleri, toplam gonadotropin dozu, toplanan oosit sayıları ve transfer edilen ortalama embriyo sayıları benzerdi. Klinik gebelik ve canlı doğum oranları istatistiksel anlamlı olmamakla birlikte B-DÇET grubunda %50 ve %22 , K-DÇET grubundan %28 ve %16.7 yüksekti.Sonuç: Dondurulmuş çözülmüş embriyo transfer siklusunda blastokist transferinin klinik sonuçları klivaj evresi embriyo transferinden daha iyi gözükmekle birlikte, her iki grup arasında klinik gebelik ve canlı doğum oranları açısından istatistiksel olarak anlamlı bir fark yoktur.

Anahtar Kelimeler

• dondurulmuş embriyo,blastokist-klivaj evresi transfer,gebelik sonuçları

Kaynakça

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