PARAOXONASE 1 ACTIVITIES IN FIRST TRIMESTER MISCARRIAGES

Öz

Aim: Miscarriages are becoming increasingly important problem nowadays. First trimester pregnancy loss frequency in women of reproductive age is increasing. In this study, it is aimed to show the possible relationship between first trimester pregnancy losses and PON1 and ARY activities. Material and Method: 25 pregnant healthy women (Group 1) and 25 women with first trimester miscarriage (Group 2) in 6-14 gestational weeks were included in this study. Paraoxonase 1 and arylesterase activities of the sera samples were investigated using fully automated colorimetric methods. ANOVA test was used to compare the groups. Results: PON1 and ARY activities are statistically significantly lower in pregnant women with first trimester miscarriage compared to healthy pregnant women in first trimester analyzed by Anova test (p<0.05). Conclusion: The results of this study showed that paraoxonase 1 and arylesterase antioxidant enzyme activities can be evaluated as significant predictive clinical laboratory parameters in first trimester pregnancy losses. If this study is confirmed with larger patient groups, our research results will gain more value.

Anahtar Kelimeler

• Pregnants
• first trimester
• miscarriage
• paraoxonase 1
• arylesterase

Birinci Trimester Düşüklerinde Paraoksonaz 1 Aktiviteleri

Öz

Amaç: Düşükler günümüzde giderek daha önemli bir sorun haline gelmektedir. Üreme çağındaki kadınlarda ilk trimester gebelik kaybının sıklığı artmaktadır. Bu çalışmada, ilk trimester gebelik kayıpları ile PON1 ve ARY düzeyleri arasındaki olası ilişkinin gösterilmesi amaçlanmıştır. Gereçler ve Yöntem: 6-14 gebelik haftasında 25 gebe sağlıklı kadın (Grup 1) ve ilk trimester düşüklü (Grup 2) 25 kadın çalışmaya dahil edildi. Serum örneklerinde paraoksonaz 1 ve arilesteraz aktiviteleri, tam otomatik kolorimetrik yöntemler kullanılarak araştırıldı. Grupları karşılaştırmak için ANOVA testi kullanıldı. Bulgular: PON1 ve ARY aktiviteleri, ilk trimesterde düşük yapan gebelerde Anova testi ile analiz edilen ilk trimesterdeki sağlıklı gebe kadınlara göre istatistiksel olarak anlamlı derecede düşüktür (p <0,05). Sonuç: Bu çalışmanın sonuçları, ilk trimester gebelik kayıplarında paraoksonaz 1 ve arilesteraz antioksidan enzim aktivitelerinin anlamlı prediktif klinik laboratuvar parametreleri olarak değerlendirilebildiğini göstermiştir. Bu çalışma daha büyük hasta gruplarıyla doğrulanırsa, araştırma sonuçlarımız değer kazanacaktır.

Anahtar Kelimeler

• Gebeler
• birinci trimester
• düşük
• paraoksonaz 1
• arilesteraz

Kaynakça

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