Servikal premalign lezyonlarda tarama testleri ve biyopsi sonuçları arasındaki uyum: Üçüncü basamak tek merkez deneyimi

Öz

Giriş ve Amaç Servikal premalign ve malign lezyonların erken tanı ve tedavisinde ve Pap (Papanicolaou) smear ve HPV tarama testlerinin önemi bilinmektedir. Bu çalışma ile üçüncü basamak tek merkez servikal tarama testi- biyopsi sonuçlarını karşılaştırmalı analiz ederek sunmayı amaçladık. Gereç ve Yöntemler Çalışmaya 3.basamak tek bir merkezde jinekolojik onkoloji polikliniğine başvuran ve kolposkopik biyopsi yapılan 272 hasta dâhil edildi. Olguların Pap smear sonuçları Betesta sistemine göre klasifiye edildi. HPV-DNA tiplendirmesi PCR yöntemi ile yapıldı. Tüm servikal biyopsi örneklerinden elde edilen H&E, p16 ve ki 67 boyalı preperatlar ışık mikroskobunda değerlendirildi. Sonuçlar istatistiksel olarak karşılaştırmalı analiz edildi. Bulgular ve sonuç HPV tarama testi, Ko-test ve Pap smear yöntemlerinin biyopsi ile uyumlarının karşılaştırılmasında HPV tarama testi anlamlı bulunmuştur (p<0,05). Ko-test ve Pap smear testi sonuçları anlamlı bulunmamıştır (p>0,05). Servikal smear testi genel topluma uygulanan bir tarama testi olup kuşkulu olgularda HPV testi yaptırmak serviks kanserini tarama açısından daha faydalı bulunmuştur.

Anahtar Kelimeler

• HPV
• serviks kanseri
• tarama testleri

The compliance between screening tests and biopsy results in cervical premalignant lesions: tertiary single-center experience

Öz

Aim The importance of Pap (Papanicolaou) smear and HPV screening tests in early diagnosis and treatment of cervical premalignant and malignant lesions are known. In this study, we aimed to present the tertiary single center cervical screening test-biopsy results by comparatively analyzing them. Material and methods The study included 272 patients who applied to the gynecological oncology outpatient clinic in a single third step center and underwent colposcopic biopsy. Pap smear results of the cases were classified according to the Bethesda system. HPV-DNA typing was done by the PCR method. H&E, p16, and ki 67 stained preparations obtained from all cervical biopsy specimens were evaluated under a light microscope. Results were statistically analyzed. Results The HPV screening test was found to be significant when comparing the compatibility of the HPV screening test, Co-test and Pap smear with biopsy (p <0.05). Co-test and Pap smear test results were not significant (p> 0.05). Conclusion The cervical smear test is a screening test applied to the general public, and the HPV test has been found more useful in screening for cervical cancer in suspected cases.

Anahtar Kelimeler

• HPV
• cervix carcinoma
• screening tests

Kaynakça

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